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An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
Abstract
Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involved in tumorigenesis. Although aberrant expression of certain miRNAs has been discovered in CaP, their function in this disease has not yet been defined. In this study, we found differential expression of miR-125b in androgen-dependent and independent CaP cells, as well as in benign and malignant prostate tissues. Furthermore, androgen signaling was able to up-regulate the expression of miR-125b . In addition, transfection of synthetic miR-125b stimulated androgen-independent growth of CaP cells and down-regulated the expression of Bak1. Our results suggest that miR-125b acts as an oncogene, contributing to the pathogenesis of CaP.
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“other microRNAs are known to target these pro-apoptotic proteins, such as miR-106b and miR-337-3p on CASP-7 [75,76], miR-17-5p, miR-132-3p and miR-212-3p on CASP-3 [76], and miR-125b on BAK [77].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [77]
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LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA
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Metadata
- Authors
- Shi, X.-B., Xue, L., Yang, J., Ma, A.-H., Zhao, J., Xu, M., Tepper, C. G., Evans, C. P., Kung, H.-J., & deVere White, R. W.
- Affiliations
- Departments of *Urology and
- Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA 95817; and
- National Research Institute for Family Planning, Peking Union Medical College, Beijing 100081, China
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-12-11
- Volume
- 104
- Issue
- 50
- Pages
- 19983-19988
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 378
- References
- 3
- Language
- en
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- Shi, X.-B., Xue, L., Yang, J., Ma, A.-H., Zhao, J., Xu, M., Tepper, C. G., Evans, C. P., Kung, H.-J., & deVere White, R. W. (2007). An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0706641104
