The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
Open accessAbstract
Caspase-1 cleaves the inactive IL-1β and IL-18 precursors into active inflammatory cytokines. In Salmonella -infected macrophages, caspase-1 also mediates a pathway of proinflammatory programmed cell death termed “pyroptosis.” We demonstrate active caspase-1 diffusely distributed in the cytoplasm and localized in discrete foci within macrophages responding to either Salmonella infection or intoxication by Bacillus anthracis lethal toxin (LT). Both stimuli triggered caspase-1-dependent lysis in macrophages and dendritic cells. Activation of caspase-1 by LT required binding, uptake, and endosome acidification to mediate translocation of lethal factor (LF) into the host cell cytosol. Catalytically active LF cleaved cytosolic substrates and activated caspase-1 by a mechanism involving proteasome activity and potassium efflux. LT activation of caspase-1 is known to require the inflammasome adapter Nalp1. In contrast, Salmonella infection activated caspase-1 through an independent pathway requiring the inflammasome adapter Ipaf. These distinct mechanisms of caspase-1 activation converged on a common pathway of caspase-1-dependent cell death featuring DNA cleavage, cytokine activation, and, ultimately, cell lysis resulting from the formation of membrane pores between 1.1 and 2.4 nm in diameter and pathological ion fluxes that can be blocked by glycine. These findings demonstrate that distinct activation pathways elicit the conserved cell death effector mechanism of caspase-1-mediated pyroptosis and support the notion that this pathway of proinflammatory programmed cell death is broadly relevant to cell death and inflammation invoked by diverse stimuli.
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Cited by
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
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Pyroptosis: host cell death and inflammation
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Self-citationPyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
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Pore-forming activity and structural autoinhibition of the gasdermin family
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Metadata
- Authors
- Fink, S. L., Bergsbaken, T., & Cookson, B. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-18
- Volume
- 105
- Issue
- 11
- Pages
- 4312-4317
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2075611712
- Cited by
- 403
- References
- 48
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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