The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes
Open accessAbstract
Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is predicted to bind to methylated promoters and silence transcription. However, the first large-scale mapping of neuronal MeCP2-binding sites on 26.3 Mb of imprinted and nonimprinted loci revealed that 59% of MeCP2-binding sites are outside of genes and that only 6% are in CpG islands. Integrated genome-wide promoter analysis of MeCP2 binding, CpG methylation, and gene expression revealed that 63% of MeCP2-bound promoters are actively expressed and that only 6% are highly methylated. These results indicate that the primary function of MeCP2 is not the silencing of methylated promoters.
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Cites
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
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Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
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DNA methylation and chromatin modification
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Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers
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Chromatin Compaction by Human MeCP2
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Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
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Cited by
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390
Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.016 · Cited by 1,329
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797
Metadata
- Authors
- Yasui, D. H., Peddada, S., Bieda, M. C., Vallero, R. O., Hogart, A., Nagarajan, R. P., Thatcher, K. N., Farnham, P. J., & LaSalle, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-04
- Volume
- 104
- Issue
- 49
- Pages
- 19416-19421
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113377321
- Cited by
- 381
- References
- 10
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. https://app.cochat.ai/papers/10.1073/pnas.0707442104
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- Yasui, D. H., Peddada, S., Bieda, M. C., Vallero, R. O., Hogart, A., Nagarajan, R. P., Thatcher, K. N., Farnham, P. J., & LaSalle, J. M. (2007). Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0707442104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
