DNA methylation and chromatin modification

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Nan, X., Ng, H.-H., Johnson, C. A., Laherty, C. D., Turner, B. M., Eisenman, R. N., & Bird, A. (1998) · Nature · doi:10.1038/30764 · Cited by 3,440 · see citing works

Histone acetylation in chromatin structure and transcription

Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884 · see citing works

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

Jones, P. L., Veenstra, G. J. C., Wade, P. A., Vermaak, D., Kass, S. U., Landsberger, N., Strouboulis, J., & Wolffe, A. P. (1998) · Nature Genetics · doi:10.1038/561 · Cited by 2,734 · see citing works

DNA Methylation and Gene Function

Razin, A., & Riggs, A. D. (1980) · Science · doi:10.1126/science.6254144 · Cited by 2,076 · see citing works

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Cameron, E. E., Bachman, K. E., Myöhänen, S., Herman, J. G., & Baylin, S. B. (1999) · Nature Genetics · doi:10.1038/5047 · Cited by 1,857 · see citing works

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Yoshida, M., Kijima, M., Akita, M., & Beppu, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44885-x · Cited by 1,856 · see citing works

Cellular differentiation, cytidine analogs and DNA methylation

Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831 · see citing works

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.

Nan, X.-S., Campoy, F., & Bird, A. (1997) · Cell · doi:10.1016/s0092-8674(00)81887-5 · Cited by 1,403 · see citing works

Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA

Lewis, J. D., Meehan, R. R., Henzel, W. J., Maurer-Fogy, I., Jeppesen, P., Klein, F., & Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90610-o · Cited by 1,371 · see citing works

Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

Hendrich, B., & Bird, A. P. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6538 · Cited by 1,352 · see citing works

Steroid receptor coactivator-1 is a histone acetyltransferase

Spencer, T. E., Jenster, G. W., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Oñate, S. A., Tsai, S. Y., Tsai, M., et al. (1997) · Nature · doi:10.1038/38304 · Cited by 1,242 · see citing works

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

Nagy, L., Kao, H.-Y., Chakravarti, D., Lin, R. J., Hassig, C. A., Ayer, D. E., Schreiber, S. L., & Evans, R. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80218-4 · Cited by 1,230 · see citing works

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210 · see citing works

The essentials of DNA methylation

Bird, A. (1992) · Cell · doi:10.1016/0092-8674(92)90526-i · Cited by 948 · see citing works

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

Laherty, C. D., Yang, W., Sun, J.-M., Davie, J., Seto, E., & Eisenman, R. N. (1997) · Cell · doi:10.1016/s0092-8674(00)80215-9 · Cited by 933 · see citing works

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841 · see citing works

What's Up and Down with Histone Deacetylation and Transcription?

Pazin, M. J., & Kadonaga, J. T. (1997) · Cell · doi:10.1016/s0092-8674(00)80211-1 · Cited by 820 · see citing works

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L., & Ayer, D. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80214-7 · Cited by 740 · see citing works

DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein

Boyes, J., & Bird, A. P. (1991) · Cell · doi:10.1016/0092-8674(91)90267-3 · Cited by 733 · see citing works

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

Nan, X., Meehan, R. R., & Bird, A. P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.21.4886 · Cited by 605 · see citing works

DNA methylation affects the formation of active chromatin

Keshet, I., Lieman‐Hurwitz, J., & Cedar, H. (1986) · Cell · doi:10.1016/0092-8674(86)90263-1 · Cited by 601 · see citing works

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578 · see citing works

Alternative chromatin structure at CpG islands

Tazi, J. (1990) · Cell · doi:10.1016/0092-8674(90)90339-g · Cited by 482 · see citing works

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

Groudine, M. T., Eisenman, R. N., & Weintraub, H. M. (1981) · Nature · doi:10.1038/292311a0 · Cited by 461 · see citing works

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulatorsPreprint

Pikaart, M. J., Targa, F. R., & Felsenfeld, G. (1998) · Genes & Development · doi:10.1101/gad.12.18.2852 · Cited by 398 · see citing works

Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominancePreprint

Chen, Z. J., & Pikaard, C. S. (1997) · Genes & Development · doi:10.1101/gad.11.16.2124 · Cited by 375 · see citing works

DNA methylation directs a time-dependent repression of transcription initiation

Kass, S. U., Landsberger, N., & Wolffe, A. P. (1997) · Current Biology · doi:10.1016/s0960-9822(97)70086-1 · Cited by 370 · see citing works

DNA Methylation Specifies Chromosomal Localization of MeCP2

Nan, X., Tate, P. H., Li, E., & Bird, A. P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.414 · Cited by 343 · see citing works

DNA Methylation: Molecular Biology and Biological Significance

Jost, J. P., & Saluz, H. P. (1993) · Medical Entomology and Zoology · Cited by 307 · see citing works

Dependence of Transcriptional Repression on CpG Methylation Density

Hsieh, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5487 · Cited by 300 · see citing works

A component of the transcriptional represser MeCP1 shares a motif with DNA methyltransferase and HRX proteins

Cross, S., Meehan, R., Nan, X.-S., & Bird, A. (1997) · Nature Genetics · doi:10.1038/ng0797-256 · Cited by 297 · see citing works

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

Stein, R., Razin, A., & Cedar, H. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.11.3418 · Cited by 283 · see citing works

DNA methylation models histone acetylation

Eden, S., Hashimshony, T., Keshet, I., Cedar, H., & Thorne, A. W. (1998) · Nature · doi:10.1038/29680 · Cited by 277 · see citing works

Analysis of estrogen receptor transcriptional enhancement by a nuclear hormone receptor coactivator.

McInerney, E. M., Tsai, M., O’Malley, B. W., & Katzenellenbogen, B. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10069 · Cited by 257 · see citing works

Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene.

Buschhausen, G., Wittig, B., Graessmann, M., & Graessmann, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1177 · Cited by 238 · see citing works

Trichostatin A causes selective loss of DNA methylation in Neurospora

Selker, E. U. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9430 · Cited by 212 · see citing works

DNA methylation: Molecular biology and biological significance

Migeon, B. R. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90253-e · Cited by 193 · see citing works

DNA Demethylation In Vitro: Involvement of RNA

Weiss, A., Keshet, I., Razin, A., & Cedar, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80146-4 · Cited by 187 · see citing works

Methyl-CpG-Binding Protein MeCP2 Represses Sp1-Activated Transcription of the Human Leukosialin Gene When the Promoter Is Methylated

Kudo, S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5492 · Cited by 153 · see citing works

Transcriptional Repression by the SMRT-mSin3 Corepressor: Multiple Interactions, Multiple Mechanisms, and a Potential Role for TFIIB

Wong, C.-W., & Privalsky, M. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5500 · Cited by 126 · see citing works

Evidence that Protein Binding Specifies Sites of DNA Demethylation

Hsieh, C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.46 · Cited by 111 · see citing works

Mismatch Repair Proteins Regulate Heteroduplex Formation during Mitotic Recombination in Yeast

Chen, W., & Jinks-Robertson, S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6525 · Cited by 110 · see citing works

An embryonic demethylation mechanism involving binding of transcription factors to replicating DNA

Matsuo, K., Silke, J., Georgiev, O., Marti, P., Giovannini, N., & Rungger, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1446 · Cited by 104 · see citing works

Modulation of plasmid DNA methylation and expression in zebrafish embryos

Collas, P. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.19.4454 · Cited by 66 · see citing works

Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA

Frémont, M., Siegmann, M., Gaulis, S., Matthies, R., Hess, D., & Jost, J. P. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.12.2375 · Cited by 62 · see citing works

DNA methylation: a secondary event in globin gene switching?Preprint

Enver, T., Zhang, J. W., Papayannopoulou, T., & Stamatoyannopoulos, G. (1988) · Genes & Development · doi:10.1101/gad.2.6.698 · Cited by 61 · see citing works

Demethylation of the progesterone receptor CpG island is not required for progesterone receptor gene expression

Ferguson, A. T., Lapidus, R. G., & Davidson, N. E. (1998) · Oncogene · doi:10.1038/sj.onc.1201961 · Cited by 39 · see citing works

Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylation

Ammerpohl, O., Schmitz, A., Steinmüller, L., & Renkawitz, R. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.23.5256 · Cited by 24 · see citing works

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

DNA Methylation-Related Chromatin Remodeling in Activity-Dependent <i>Bdnf</i> Gene Regulation

Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Zhang, Y., Ng, H.-H., Erdjument-Bromage, H., Tempst, P., Bird, A., & Reinberg, D. (1999) · Genes &amp; Development · doi:10.1101/gad.13.15.1924 · Cited by 1,103 · see citing works

Histone methylation in transcriptional control

Kouzarides, T. (2002) · Current Opinion in Genetics &amp; Development · doi:10.1016/s0959-437x(02)00287-3 · Cited by 908 · see citing works

Epigenetic Regulation of <i>bdnf</i> Gene Transcription in the Consolidation of Fear Memory

Lubin, F. D., Roth, T. L., & Sweatt, J. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1786-08.2008 · Cited by 793 · see citing works

The sperm epigenome and potential implications for the developing embryo

Jenkins, T. G., & Carrell, D. T. (2012) · Reproduction · doi:10.1530/rep-11-0450 · Cited by 232 · see citing works

Synergistic Effect of Histone Hyperacetylation and DNA Demethylation in the Reactivation of the FMR1 Gene

Chiurazzi, P., Grazia Pomponi, M., Pietrobono, R., Bakker, C. E., Neri, G., & Oostra, B. A. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.12.2317 · Cited by 217 · see citing works

Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b

Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D. G., Hozumi, N., & Oikawa, T. (2006) · Oncogene · doi:10.1038/sj.onc.1209272 · Cited by 132 · see citing works

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation

Celik, H., Mallaney, C., Kothari, A., Ostrander, E. L., Eultgen, E., Martens, A., Miller, C. A., Hundal, J., Klco, J. M., & Challen, G. A. (2015) · Blood · doi:10.1182/blood-2014-08-594564 · Cited by 95 · see citing works

Correlation between dioxin and endometriosis: an epigenetic route to unravel the pathogenesis of the disease

Sofo, V., Götte, M., Laganà, A. S., Salmeri, F. M., Triolo, O., Sturlese, E., Retto, G., Alfa, M., Granese, R., & Abrão, M. S. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3739-5 · Cited by 88 · see citing works

Notch2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells

Lee, K. M., Yasuda, H., Hollingsworth, M. A., & Ouellette, M. M. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700298 · Cited by 88 · see citing works

Epigenetic changes following traumatic brain injury and their implications for outcome, recovery and therapy

Wong, V. S., & Langley, B. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.009 · Cited by 85 · see citing works

Altered genome-wide methylation in endometriosis

Naqvi, H., Ilagan, Y., Krikun, G., & Taylor, H. S. (2014) · Reproductive Sciences · doi:10.1177/1933719114532841 · Cited by 82 · see citing works

The Rb/chromatin connection and epigenetic control: opinion

Ferreira, R., Naguibneva, I., Pritchard, L. L., Ait-Si-Ali, S., & Harel-Bellan, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204337 · Cited by 76 · see citing works

Genetic modifiers of MeCP2 function in Drosophila

Cukier, H. N., Perez, A. M., Collins, A. L., Zhou, Z., Zoghbi, H. Y., & Botas, J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000179 · Cited by 73 · see citing works

Senescence and epigenetic dysregulation in cancer

Neumeister, P., Albanese, C., Balent, B., Greally, J., & Pestell, R. G. (2002) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/s1357-2725(02)00079-1 · Cited by 56 · see citing works

Retinoblastoma tumor suppressor and genome stability

(2002) · Advances in Cancer Research · doi:10.1016/s0065-230x(02)85002-3 · Cited by 48 · see citing works

H3K9 acetylation of Tph2 involved in depression-like behavior in Male, but not female, juvenile offspring rat induced by prenatal stress

Dang, S., Lu, Y., Su, Q., Lin, T., Zhang, X., Zhang, H., Zhang, J., Zhang, L., Zhu, Z., & Li, H. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.043 · Cited by 30 · see citing works

Sequence-specific and Methylation-dependent and -independent Binding of Rice Nuclear Proteins to a Rice Tungro Bacilliform Virus Vascular Bundle Expression Element

He, X., Fütterer, J., & Hohn, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006653200 · Cited by 9 · see citing works

Epigenomics - Genome Wide Modifications of Cytosine and New Dimensions in Our Understanding of Differentiation and Disease

Coverdale, L. E., & Martin, C. (2005) · Current Genomics · doi:10.2174/138920205775067657 · Cited by 1 · see citing works

Chromatin dynamics: Interplay between remodeling enzymes and histone modifications

Swygert, S. G., & Peterson, C. L. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.02.013 · Cited by 257 · see citing works

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039 · see citing works

Beyond the Double Helix: Writing and Reading the Histone Code

Wang, Y., Fischle, W., Cheung, W. L., et al. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch2 · Cited by 173 · see citing works

ATP-dependent chromatin remodeling factors: Nucleosome shufflers with many missions

Varga‐Weisz, P. (2001) · Oncogene · doi:10.1038/sj.onc.1204332 · Cited by 132 · see citing works