The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Profiling of UV-induced ATM/ATR signaling pathways
Open accessAbstract
To ensure survival in the face of genomic insult, cells have evolved complex mechanisms to respond to DNA damage, termed the DNA damage checkpoint. The serine/threonine kinases ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) activate checkpoint signaling by phosphorylating substrate proteins at SQ/TQ motifs. Although some ATM/ATR substrates (Chk1, p53) have been identified, the lack of a more complete list of substrates limits current understanding of checkpoint pathways. Here, we use immunoaffinity phosphopeptide isolation coupled with mass spectrometry to identify 570 sites phosphorylated in UV-damaged cells, 498 of which are previously undescribed. Semiquantitative analysis yielded 24 known and 192 previously uncharacterized sites differentially phosphorylated upon UV damage, some of which were confirmed by SILAC, Western blotting, and immunoprecipitation/Western blotting. ATR-specific phosphorylation was investigated by using a Seckel syndrome (ATR mutant) cell line. Together, these results provide a rich resource for further deciphering ATM/ATR signaling and the pathways mediating the DNA damage response.
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Cites
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TM4: a free, open-source system for microarray data management and analysis
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The DNA damage response: putting checkpoints in perspective
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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
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Cited by
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798
DNA Damage Sensing by the ATM and ATR Kinases
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ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
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Metadata
- Authors
- Stokes, M. P., Rush, J., MacNeill, J., Ren, J. M., Sprott, K., Nardone, J., Yang, V., Beausoleil, S. A., Gygi, S. P., Livingstone, M., Zhang, H., Polakiewicz, R. D., & Comb, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-11
- Volume
- 104
- Issue
- 50
- Pages
- 19855-19860
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007942027
- Cited by
- 315
- References
- 11
- FWCI
- 7.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Stokes, M. P., Rush, J., MacNeill, J., Ren, J. M., Sprott, K., Nardone, J., Yang, V., Beausoleil, S. A., Gygi, S. P., Livingstone, M., Zhang, H., Polakiewicz, R. D., & Comb, M. J. (2007). Profiling of UV-induced ATM/ATR signaling pathways. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0707579104
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