The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
Open accessAbstract
Ataxia telangiectasia (A-T) is a human disease caused by ATM deficiency characterized among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and neurological defects. ATM controls several aspects of cell cycle and promotes repair of double strand breaks (DSBs). This probably accounts for most of A-T clinical manifestations. However, an impaired response to reactive oxygen species (ROS) might also contribute to A-T pathogenesis. Here, we show that ATM promotes an anti-oxidant response by regulating the pentose phosphate pathway (PPP). ATM activation induces glucose-6-phosphate dehydrogenase (G6PD) activity, the limiting enzyme of the PPP responsible for the production of NADPH, an essential anti-oxidant cofactor. ATM promotes Hsp27 phosphorylation and binding to G6PD, stimulating its activity. We also show that ATM-dependent PPP stimulation increases nucleotide production and that G6PD-deficient cells are impaired for DSB repair. These data suggest that ATM protects cells from ROS accumulation by stimulating NADPH production and promoting the synthesis of nucleotides required for the repair of DSBs.
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1 retracted
Fico, A., Paglialunga, F., Cigliano, L., Abrescia, P., Verde, P., Martini, G., Iaccarino, I., & Filosa, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401420 · Cited by 147
RetractedATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Cancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · cited 1×
“This phenomenon is known as Warburg effect (Hsu and Sabatini, 2008).”
BackgroundTIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis
Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019
Glucose-6-phosphate dehydrogenase deficiency
Cappellini, M., & Fiorelli, G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60073-2 · Cited by 1,590
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 2×
“The work must be attributed back to the original author and commercial use is not permitted without specific permission.”
BackgroundATM Activation by Oxidative Stress
Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079
Rogalla, T., Ehrnsperger, M., Preville, X., Kotlyarov, A., Lutsch, G., Ducasse, C., Paul, C., Wieske, M., Arrigo, A.-P., Buchner, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.18947 · Cited by 742
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Kawauchi, K., Araki, K., Tobiume, K., & Tanaka, N. (2008) · Nature Cell Biology · doi:10.1038/ncb1724 · Cited by 637
Importance of Glucose-6-phosphate Dehydrogenase Activity for Cell Growth
Tian, W.-N., Braunstein, L. D., Pang, J., Stuhlmeier, K. M., Xi, Q.-C., Tian, X., & Stanton, R. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10609 · Cited by 532
Cited by
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654
Signal transduction by reactive oxygen species
Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322
“A similar situation exists for the FoxO family of transcription factors that alter their subcellular localization based on the intracellular redox state and in turn, regulate the expression of various antioxidant genes (de Keizer et al., 2011).”
BackgroundThe ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
Metadata
- Authors
- Cosentino, C., Grieco, D., & Costanzo, V.
- Venue
- The EMBO Journal
- Published
- 2010-12-14
- Volume
- 30
- Issue
- 3
- Pages
- 546-555
- ISSN
- 0261-4189 (ISSN-L)
- OpenAlex
- W2111768081
- Cited by
- 435
- References
- 50
- FWCI
- 9.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cosentino, C., Grieco, D., & Costanzo, V. (2011). ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. The EMBO Journal. https://doi.org/10.1038/emboj.2010.330
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