The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
Open accessAbstract
Small noncoding RNAs, microRNAs (miRNAs), bind to messenger RNAs through base pairing to suppress gene expression. Despite accumulating evidence that miRNAs play critical roles in various biological processes across diverse organisms, their roles in mammalian skeletal development have not been demonstrated. Here, we show that Dicer, an essential component for biogenesis of miRNAs, is essential for normal skeletal development. Dicer -null growth plates show a progressive reduction in the proliferating pool of chondrocytes, leading to severe skeletal growth defects and premature death of mice. The reduction of proliferating chondrocytes in Dicer -null growth plates is caused by two distinct mechanisms: decreased chondrocyte proliferation and accelerated differentiation into postmitotic hypertrophic chondrocytes. These defects appear to be caused by mechanisms downstream or independent of the Ihh-PTHrP signaling pathway, a pivotal signaling system that regulates chondrocyte proliferation and differentiation. Microarray analysis of Dicer -null chondrocytes showed limited expression changes in miRNA-target genes, suggesting that, in the majority of cases, chondrocytic miRNAs do not directly regulate target RNA abundance. Our results demonstrate the critical role of the Dicer-dependent pathway in the regulation of chondrocyte proliferation and differentiation during skeletal development.
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Cites
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Self-citationMicroRNA-140 plays dual roles in both cartilage development and homeostasis
Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., et al. (2010) · Genes & Development · doi:10.1101/gad.1915510 · Cited by 660
miR-214 targets ATF4 to inhibit bone formation
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A microRNA signature for a BMP2-induced osteoblast lineage commitment program
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Metadata
- Authors
- Kobayashi, T., Lu, J., Cobb, B. S., Rodda, S. J., McMahon, A. P., Schipani, E., Merkenschlager, M., & Kronenberg, H. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-12
- Volume
- 105
- Issue
- 6
- Pages
- 1949-1954
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968414953
- Cited by
- 334
- References
- 8
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kobayashi, T., Lu, J., Cobb, B. S., Rodda, S. J., McMahon, A. P., Schipani, E., Merkenschlager, M., & Kronenberg, H. M. (2008). Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0707900105
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