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Cited by 1,436

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Giraldez, Antonio J., Mishima, Yuichiro, Rihel, Jason, Grocock, Russell J., Van Dongen, Stijn, Inoue, Kunio, Enright, Anton J., Schier, Alexander F.·2006·Science
DOI 10.1126/science.1122689
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Abstract

MicroRNAs (miRNAs) comprise 1 to 3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. By using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target messenger RNA molecules (mRNAs). Most targets are maternally expressed mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis.

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Crossref · 10.1126/science.1122689

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6 of 6 references verified0 citation errors · 0 not checkable

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  • It is very likely that most miRNAs have many, perhaps as many as a few thousand, mRNA targets.

    “We also find that neurons express multiple miRNAs and it is very likely that most miRNAs have many, perhaps as many as a few thousand, mRNA targets [1,2,6,56].”

    From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [6]

  • In zebrafish, miR-430 targets a large number of maternally deposited transcripts at the onset of zygotic transcription.

    “For instance, in zebrafish, miR-430 targets a large number of maternally deposited transcripts at the onset of zygotic transcription [6] and many examples of spatially exclusive expression domains of miRNAs and their targets have been documented (for example, [12,53]).”

    From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [6]

  • Major changes in the transcriptome that occur when cells transition between states are thought to be brought about by transcriptional mechanisms independent of miRNA function and so it seems likely that many target mRNAs will not be actively transcribed once a transition has occurred.

    “Major changes in the transcriptome that occur when cells transition between states are thought to be brought about by transcriptional mechanisms independent of miRNA function and so it seems likely that many target mRNAs will not be actively transcribed once a transition has occurred (for example, [6]).”

    From MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system (2007) · cites this paper as [6]

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Authors
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2006-04-07
Volume
312
Issue
5770
Pages
75-79
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1122689
Cited by
1,436
References
6
Language
en

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