Engineering Nano‐Therapeutics to Boost Adoptive Cell Therapy for Cancer Treatment

Car t cell immunotherapy for human cancer

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Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

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Cancer regression in patients after transfer of genetically engineered lymphocytes

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Shape effects of filaments versus spherical particles in flow and drug delivery

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Adoptive cell transfer as personalized immunotherapy for human cancer

Rosenberg, S. A., & Restifo, N. P. (2015) · Science · doi:10.1126/science.aaa4967 · Cited by 2,492 · see citing works

Chimeric Antigen Receptor Therapy

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Taking dendritic cells into medicine

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Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

Brentjens, R. J., Davila, M. L., Riviere, I., Park, J., Wang, X., Cowell, L. G., Bartido, S., Stefanski, J., Taylor, C., Olszewska, M., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005930 · Cited by 2,063 · see citing works

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

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Iron oxide MR contrast agents for molecular and cellular imaging

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Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Rafiq, S., Hackett, C. S., & Brentjens, R. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0297-y · Cited by 1,477 · see citing works

Nanoparticles target distinct dendritic cell populations according to their size

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Bio-inspired, bioengineered and biomimetic drug delivery carriers

Yoo, J., Irvine, D. J., Discher, D. E., & Mitragotri, S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3499 · Cited by 1,233 · see citing works

Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging.

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Mechanisms of resistance to CAR T cell therapy

Shah, N. N., & Fry, T. J. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0184-6 · Cited by 984 · see citing works

CAR T Cell Therapy for Solid Tumors

Newick, K., O'Brien, S., Moon, E., & Albelda, S. M. (2017) · Annual Review of Medicine · doi:10.1146/annurev-med-062315-120245 · Cited by 909 · see citing works

Enhancing cancer immunotherapy with nanomedicine

Irvine, D. J., & Dane, E. L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-019-0269-6 · Cited by 900 · see citing works

Toxicity and management in CAR T-cell therapy

Bonifant, C. L., Jackson, H. J., Brentjens, R. J., & Curran, K. J. (2016) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2016.11 · Cited by 892 · see citing works

Role of Particle Size in Phagocytosis of Polymeric Microspheres

Champion, J. A., Walker, A. H., & Mitragotri, S. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9562-y · Cited by 887 · see citing works

Therapeutic T cell engineering

Sadelain, M., Rivière, I., & Riddell, S. R. (2017) · Nature · doi:10.1038/nature22395 · Cited by 886 · see citing works

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

Smith, T. T., Stephan, S. B., Moffett, H. F., McKnight, L. E., Ji, W., Reiman, D., Bonagofski, E., Wohlfahrt, M. E., Pillai, S. P. S., & Stephan, M. T. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.57 · Cited by 788 · see citing works

Therapeutic cell engineering with surface-conjugated synthetic nanoparticles

Stephan, M. T., Moon, J. J., Um, S. H., Bershteyn, A., & Irvine, D. J. (2010) · Nature Medicine · doi:10.1038/nm.2198 · Cited by 752 · see citing works

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Ellebrecht, C. T., Bhoj, V. G., Nace, A., Choi, E. J., Mao, X., Cho, M. J., Zenzo, G. D., Lanzavecchia, A., Seykora, J. T., Cotsarelis, G., et al. (2016) · Science · doi:10.1126/science.aaf6756 · Cited by 742 · see citing works

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

Zeng, R., Spolski, R. J., Finkelstein, S. E., Oh, S., Kovanen, P. E., Hinrichs, C. S., Pise-Masison, C. A., Radonovich, M. F., Brady, J. N., Restifo, N. P., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041057 · Cited by 726 · see citing works

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

Shrimali, R. K., Yu, Z., Theoret, M. R., Chinnasamy, D., Restifo, N. P., & Rosenberg, S. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0153 · Cited by 677 · see citing works

siRNA Delivery into Human T Cells and Primary Cells with Carbon‐Nanotube Transporters

Liu, Z., Winters, M. A., Holodniy, M., & Dai, H. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200604295 · Cited by 666 · see citing works

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Tang, L., Zheng, Y., Melo, M. B., Mabardi, L., Castaño, A. P., Xie, Y., Li, N., Kudchodkar, S. B., Wong, H. C., Jeng, E. K., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4181 · Cited by 663 · see citing works

Clinical manufacturing of CAR T cells: foundation of a promising therapy

Wang, X., & Rivière, I. (2016) · Molecular Therapy - Oncolytics · doi:10.1038/mto.2016.15 · Cited by 637 · see citing works

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636 · see citing works

Improving cancer immunotherapy through nanotechnology

Goldberg, M. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0186-9 · Cited by 628 · see citing works

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

Liu, C., Zhang, L., Liu, H., & Cheng, K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.012 · Cited by 607 · see citing works

In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells

Galanzha, E. I., Shashkov, E. V., Kelly, T. J., Kim, J.-W., Yang, L. P. H., & Zharov, V. P. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.333 · Cited by 576 · see citing works

Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers

Muro, S., Garnacho, C., Champion, J. A., Leferovich, J. M., Gajewski, C., Schuchman, E. H., Mitragotri, S., & Muzykantov, V. R. (2008) · Molecular Therapy · doi:10.1038/mt.2008.127 · Cited by 564 · see citing works

Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells

Shalek, A. K., Robinson, J. T., Karp, E. S., Lee, J. S., Ahn, D., Yoon, M., Sutton, A., Jorgolli, M., Gertner, R. S., Gujral, T. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909350107 · Cited by 563 · see citing works

Altered TCR Signaling from Geometrically Repatterned Immunological Synapses

Mossman, K. D., Campi, G., Groves, J. T., & Dustin, M. L. (2005) · Science · doi:10.1126/science.1119238 · Cited by 547 · see citing works

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

Kim, J., Li, A. W., Choi, Y., Lewin, S. A., Verbeke, C. S., Dranoff, G., & Mooney, D. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3071 · Cited by 541 · see citing works

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Krishna, S., Lowery, F. J., Copeland, A. R., Bahadiroglu, E., Mukherjee, R., Jia, L., Anibal, J., Sachs, A., Adebola, S. O., Gurusamy, D., et al. (2020) · Science · doi:10.1126/science.abb9847 · Cited by 541 · see citing works

Chimeric antigen receptor T-cell therapies for lymphoma

Brudno, J. N., & Kochenderfer, J. N. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.128 · Cited by 518 · see citing works

Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints

Mikucki, M. E., Fisher, D. T., Matsuzaki, J., Skitzki, J. J., Gaulin, N. B., Muhitch, J. B., Ku, A. W., Frelinger, J. G., Odunsi, K., Gajewski, T. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8458 · Cited by 512 · see citing works

MRI detection of single particles for cellular imaging

Shapiro, E. M., Skrtic, S., Sharer, K., Hill, J. M., Dunbar, C. E., & Koretsky, A. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403918101 · Cited by 499 · see citing works

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

Parkhurst, M. R., Riley, J. P., Dudley, M. E., & Rosenberg, S. A. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1347 · Cited by 477 · see citing works

Nanoparticle-Based Immunotherapy for Cancer

Shao, K., Singha, S., Clemente‐Casares, X., Tsai, S. J., Yang, Y., & Santamaría, P. (2014) · ACS Nano · doi:10.1021/nn5062029 · Cited by 472 · see citing works

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Q., Hu, Q., Dukhovlinova, E., Chen, G., Ahn, S., Wang, C., Ogunnaike, E. A., Ligler, F. S., Dotti, G., & Gu, Z. (2019) · Advanced Materials · doi:10.1002/adma.201900192 · Cited by 469 · see citing works

Biomaterial-assisted targeted modulation of immune cells in cancer treatment

Wang, H., & Mooney, D. J. (2018) · Nature Materials · doi:10.1038/s41563-018-0147-9 · Cited by 468 · see citing works

Polymer particle shape independently influences binding and internalization by macrophages

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T cell‐targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

Schmid, D., Park, C. G., Hartl, C. A., Subedi, N., Cartwright, A. N., Puerto, R. B., Zheng, Y., Maiarana, J., Freeman, G. J., Wucherpfennig, K. W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01830-8 · Cited by 449 · see citing works

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

Stephan, S. B., Taber, A. M., Jileaeva, I., Pegues, E. P., Sentman, C. L., & Stephan, M. T. (2014) · Nature Biotechnology · doi:10.1038/nbt.3104 · Cited by 440 · see citing works

Programming CAR-T cells to kill cancer

Labanieh, L., Majzner, R. G., & Mackall, C. L. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0235-9 · Cited by 439 · see citing works

Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor

Ma, L., Dichwalkar, T., Chang, J. Y. H., Cossette, B. J., Garafola, D., Zhang, A. Q., Fichter, M., Wang, C., Liang, S., Silva, M., et al. (2019) · Science · doi:10.1126/science.aav8692 · Cited by 439 · see citing works

Engineered nanomedicines with enhanced tumor penetration

Ding, J., Chen, J., Gao, L., Jiang, Z., Zhang, Y., Li, M., Xiao, Q., Lee, S. S., & Chen, X. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100800 · Cited by 422 · see citing works

Injectable cryogel-based whole-cell cancer vaccines

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Trafficking of T Cells into Tumors

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Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia

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Adoptive cellular therapy: A race to the finish line

June, C. H., Riddell, S. R., & Schumacher, T. N. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa3643 · Cited by 402 · see citing works

Drug delivery by red blood cells: vascular carriers designed by mother nature

Muzykantov, V. R. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425241003610633 · Cited by 399 · see citing works

Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells

Cheung, A. S., Zhang, D. K. Y., Koshy, S. T., & Mooney, D. J. (2018) · Nature Biotechnology · doi:10.1038/nbt.4047 · Cited by 379 · see citing works

In vivo detection of single cells by MRI

Shapiro, E. M., Sharer, K., Skrtic, S., & Koretsky, A. P. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20718 · Cited by 378 · see citing works

Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells

Anselmo, A. C., Gupta, V., Zern, B. J., Pan, D. C., Zakrewsky, M., Muzykantov, V. R., & Mitragotri, S. (2013) · ACS Nano · doi:10.1021/nn404853z · Cited by 366 · see citing works

Spinning molecular immunology into successful immunotherapy

Pardoll, D. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri774 · Cited by 360 · see citing works

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells

Levine, B. L., Bernstein, W. B., Connors, M., Craighead, N., Lindsten, T., Thompson, C. B., & June, C. H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.5921 · Cited by 340 · see citing works

Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

Smith, T. T., Moffett, H. F., Stephan, S. B., Opel, C. F., Dumigan, A., Jiang, X., Pillarisetty, V. G., Pillai, S. P. S., Wittrup, K. D., & Stephan, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87624 · Cited by 339 · see citing works

Nanomaterials for T-cell cancer immunotherapy

Gong, N., Sheppard, N. C., Billingsley, M. M., June, C. H., & Mitchell, M. J. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00822-y · Cited by 314 · see citing works

Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know

Rosenberg, S. A. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.116 · Cited by 312 · see citing works

Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy

Mok, S., Koya, R. C., Tsui, C. T., Xu, J., Robert, L., Wu, L., Graeber, T. G., West, B. L., Bollag, G. E., & Ribas, A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1816 · Cited by 311 · see citing works

Immunotherapy and tumor microenvironment

Tang, H., Qiao, J., & Fu, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.009 · Cited by 306 · see citing works

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

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Upconversion luminescence imaging of cells and small animals

Liu, Q., Feng, W., Yang, T., Yi, T., & Li, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.114 · Cited by 291 · see citing works

Amplifying the Red-Emission of Upconverting Nanoparticles for Biocompatible Clinically Used Prodrug-Induced Photodynamic Therapy

Punjabi, A., Wu, X., Tokatli-Apollon, A., El-Rifai, M., Lee, H., Zhang, Y., Wang, C., Liu, Z., Chan, E. M., Duan, C., et al. (2014) · ACS Nano · doi:10.1021/nn505051d · Cited by 290 · see citing works

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Wang, C., Ye, Y., Hu, Q., Bellotti, A., & Gu, Z. (2017) · Advanced Materials · doi:10.1002/adma.201606036 · Cited by 288 · see citing works

Modulating Adaptive Immune Responses to Peptide Self-Assemblies

Rudra, J. S., Sun, T., Bird, K., Daniels, M. D., Gasiorowski, J. Z., Chong, A. S., & Collier, J. H. (2012) · ACS Nano · doi:10.1021/nn204530r · Cited by 277 · see citing works

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

Stephan, M. T., & Irvine, D. J. (2011) · Nano Today · doi:10.1016/j.nantod.2011.04.001 · Cited by 267 · see citing works

High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents

Polyak, B., Fishbein, I., Chorny, M., Alferiev, I., Williams, D., Yellen, B., Friedman, G., & Levy, R. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708338105 · Cited by 257 · see citing works

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

Sunshine, J. C., Perica, K., Schneck, J. P., & Green, J. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.050 · Cited by 245 · see citing works

Tailoring T-cell receptor signals by proximal negative feedback mechanisms

Acuto, O., Bartolo, V. D., & Michel, F. (2008) · Nature reviews. Immunology · doi:10.1038/nri2397 · Cited by 245 · see citing works

A carbon nanotube–polymer composite for T-cell therapy

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Nanomedicine for Cancer Immunotherapy: Tracking Cancer-Specific T-Cells in Vivo with Gold Nanoparticles and CT Imaging

Meir, R., Shamalov, K., Betzer, O., Motiei, M., Horovitz‐Fried, M., Yehuda, R., Popovtzer, A., Popovtzer, R., & Cohen, C. J. (2015) · ACS Nano · doi:10.1021/acsnano.5b01939 · Cited by 240 · see citing works

Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

Perica, K., Tu, A. A., Richter, A., Bieler, J. G., Edidin, M. A., & Schneck, J. P. (2014) · ACS Nano · doi:10.1021/nn405520d · Cited by 237 · see citing works

Chimeric antigen receptor T-cell therapy for solid tumors

Newick, K., Moon, E. K., & Albelda, S. Μ. (2016) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2016.6 · Cited by 237 · see citing works

Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy

Xiang, J., Xu, L., Gong, H., Zhu, W., Wang, C., Xu, J., Feng, L., Cheng, L., Peng, R., & Liu, Z. (2015) · ACS Nano · doi:10.1021/acsnano.5b02014 · Cited by 231 · see citing works

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

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Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells

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Principles of adoptive T cell therapy in cancer

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Biomimetic Magnetosomes as Versatile Artificial Antigen-Presenting Cells to Potentiate T-Cell-Based Anticancer Therapy

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In vivo generation of human CD19‐CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

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Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles

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Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

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How Shape Influences Uptake: Interactions of Anisotropic Polymer Nanoparticles and Human Mesenchymal Stem Cells

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Artificially Reprogrammed Macrophages as Tumor‐Tropic Immunosuppression‐Resistant Biologics to Realize Therapeutics Production and Immune Activation

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Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy

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