The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends
Open accessAbstract
XRCC4-null mice have a more severe phenotype than KU80-null mice. Here, we address whether this difference in phenotype is connected to nonhomologous end-joining (NHEJ). We used intrachromosomal substrates to monitor NHEJ of two distal double-strand breaks (DSBs) targeted by I-SceI, in living cells. In xrcc4 -defective XR-1 cells, a residual but significant end-joining process exists, which primarily uses microhomologies distal from the DSB. However, NHEJ efficiency was strongly reduced in xrcc4 -defective XR-1 cells versus complemented cells, contrasting with KU-deficient xrs6 cells, which showed levels of end-joining similar to those of complemented cells. Nevertheless, sequence analysis of the repair junctions indicated that the accuracy of end-joining was strongly affected in both xrcc4 -deficient and KU-deficient cells. More specifically, these data showed that the KU80/XRCC4 pathway is conservative and not intrinsically error-prone but can accommodate non-fully complementary ends at the cost of limited mutagenesis.
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Cites
Homology-directed repair is a major double-strand break repair pathway in mammalian cells
Liang, F., Han, M., Romanienko, P. J., & Jasin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5172 · Cited by 649
Positional stability of single double-strand breaks in mammalian cells
Soutoglou, E., Dorn, J. F., Sengupta, K., Jasin, M., Nussenzweig, A., Ried, T., Danuser, G., & Misteli, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1591 · Cited by 509
Zhu, C., Mills, K. D., Ferguson, D. O., Lee, C., Manis, J., Fleming, J., Gao, Y., Morton, C. C., & Alt, F. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00770-5 · Cited by 421
Cited by
MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings
McVey, M., & Lee, S. E. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.08.007 · Cited by 986
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
Bennardo, N., Cheng, A., Huang, N., & Stark, J. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000110 · Cited by 870
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357
Gunn, A., & Stark, J. M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-998-3_27 · Cited by 359
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J.-B., Sallmyr, A., Ruis, B., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.002 · Cited by 351
“Junctions that form by alt-NHEJ have more microhomology and longer deletions than junctions formed by c-NHEJ (Fattah et al., 2010; Guirouilh-Barbat et al., 2007; Kabotyanski et al., 1998; Oh et al., 2013; Simsek and Jasin, 2010; Smith et al., 2003).”
Background
Metadata
- Authors
- Guirouilh-Barbat, J., Rass, E., Plo, I., Bertrand, P., & Lopez, B. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-26
- Volume
- 104
- Issue
- 52
- Pages
- 20902-20907
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970347880
- Cited by
- 184
- References
- 3
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Guirouilh-Barbat, J., Rass, E., Plo, I., Bertrand, P., & Lopez, B. S. (2007). Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0708541104
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