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Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z
Open accessAbstract
The permeability and solute transport characteristics of amphiphilic triblock-polymer vesicles containing the bacterial water-channel protein Aquaporin Z (AqpZ) were investigated. The vesicles were made of a block copolymer with symmetric poly-(2-methyloxazoline)-poly-(dimethylsiloxane)-poly-(2-methyloxazoline) (PMOXA 15 -PDMS 110 -PMOXA 15 ) repeat units. Light-scattering measurements on pure polymer vesicles subject to an outwardly directed salt gradient in a stopped-flow apparatus indicated that the polymer vesicles were highly impermeable. However, a large enhancement in water productivity (permeability per unit driving force) of up to ≈800 times that of pure polymer was observed when AqpZ was incorporated. The activation energy ( E a ) of water transport for the protein-polymer vesicles (3.4 kcal/mol) corresponded to that reported for water-channel-mediated water transport in lipid membranes. The solute reflection coefficients of glucose, glycerol, salt, and urea were also calculated, and indicated that these solutes are completely rejected. The productivity of AqpZ-incorporated polymer membranes was at least an order of magnitude larger than values for existing salt-rejecting polymeric membranes. The approach followed here may lead to more productive and sustainable water treatment membranes, whereas the variable levels of permeability obtained with different concentrations of AqpZ may provide a key property for drug delivery applications.
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Cited by
Applications of nanotechnology in water and wastewater treatment
Qu, X., Alvarez, P. J. J., & Li, Q. (2013) · Water Research · doi:10.1016/j.watres.2012.09.058 · Cited by 2,444
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Stimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijen, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122
Polymer-matrix nanocomposite membranes for water treatment
Yin, J., & Deng, B. (2015) · Journal of Membrane Science · doi:10.1016/j.memsci.2014.11.019 · Cited by 1,089
Qu, X., Brame, J., Li, Q., & Alvarez, P. J. J. (2013) · Accounts of Chemical Research · doi:10.1021/ar300029v · Cited by 799
Metadata
- Authors
- Kumar, M., Grzelakowski, M., Zilles, J., Clark, M., & Meier, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-26
- Volume
- 104
- Issue
- 52
- Pages
- 20719-20724
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061718144
- Cited by
- 716
- References
- 0
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Kumar, M., Grzelakowski, M., Zilles, J., Clark, M., & Meier, W. (2007). Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0708762104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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