The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
Open accessAbstract
Evolutionarily significant selective sweeps may result in long stretches of homozygous polymorphisms in individuals from outbred populations. We developed whole-genome homozygosity association (WGHA) methodology to characterize this phenomenon in healthy individuals and to use this genomic feature to identify genetic risk loci for schizophrenia (SCZ). Applying WGHA to 178 SCZ cases and 144 healthy controls genotyped at 500,000 markers, we found that runs of homozygosity (ROHs), ranging in size from 200 kb to 15 mb, were common in unrelated Caucasians. Properties of common ROHs in healthy subjects, including chromosomal location and presence of nonancestral haplotypes, converged with prior reports identifying regions under selective pressure. This interpretation was further supported by analysis of multiethnic HapMap samples genotyped with the same markers. ROHs were significantly more common in SCZ cases, and a set of nine ROHs significantly differentiated cases from controls. Four of these 9 “risk ROHs” contained or neighbored genes associated with SCZ ( NOS1AP , ATF2 , NSF , and PIK3C3 ). Several of these risk ROHs were very rare in healthy subjects, suggesting that recessive effects of relatively high penetrance may explain a proportion of the genetic liability for SCZ. Other risk ROHs feature haplotypes that are also common in healthy individuals, possibly indicating a source of balancing selection.
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Cites
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Cited by
Runs of Homozygosity in European Populations
McQuillan, R., Leutenegger, A.-L., Abdel-Rahman, R., Franklin, C. S., Pericic, M., Barac-Lauc, L., Smolej-Narancic, N., Janicijevic, B., Polasek, O., Tenesa, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.08.007 · Cited by 1,369
Runs of homozygosity: windows into population history and trait architecture
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Schizophrenia, “Just the Facts” What we know in 2008. 2. Epidemiology and etiology
TANDON, R., KESHAVAN, M., & NASRALLAH, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.011 · Cited by 720
Keller, M. C., Visscher, P. M., & Goddard, M. E. (2011) · Genetics · doi:10.1534/genetics.111.130922 · Cited by 543
Inbreeding and runs of homozygosity: A possible solution to an old problem
Curik, I., Ferenčaković, M., & Sölkner, J. (2014) · Livestock Science · doi:10.1016/j.livsci.2014.05.034 · Cited by 419
Metadata
- Authors
- Lencz, T., Lambert, C., DeRosse, P., Burdick, K. E., Morgan, T. V., Kane, J. M., Kucherlapati, R., & Malhotra, A. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-12-11
- Volume
- 104
- Issue
- 50
- Pages
- 19942-19947
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2127450586
- Cited by
- 429
- References
- 12
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Lencz, T., Lambert, C., DeRosse, P., Burdick, K. E., Morgan, T. V., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2007). Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0710021104
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