Cited by 346Chromosomal and Genetic VariationsEvolution and Genetic DynamicsDNA Repair Mechanisms

An evolutionary view of human recombination

Coop, Graham, Przeworski, Molly·2007·Nature Reviews Genetics

Abstract

Recombination has essential functions in mammalian meiosis, which impose several constraints on the recombination process. However, recent studies have shown that, in spite of these roles, recombination rates vary tremendously among humans, and show marked differences between humans and closely related species. These findings provide important insights into the determinants of recombination rates and raise new questions about the selective pressures that affect recombination over different genomic scales, with implications for human genetics and evolutionary biology.

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Crossref · 10.1038/nrg1947

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Authors
Coop, G., & Przeworski, M.
Affiliations
University of Chicago (US)
Corresponding author
Przeworski, Molly
Venue
Nature Reviews Genetics
Published
2006-12-05
Volume
8
Issue
1
Pages
23-34
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W2085231911
Cited by
344
References
143
Citations by year
2026: 5 · 2025: 15 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 53 · 2020: 10 · 2019: 14 · 2018: 13 · 2017: 25 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 12
FWCI
1.35
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Chicago
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
meiotic recombination, recombination rate variation, mammalian meiosis, recombination hotspots, recombination rate evolution, comparative genomics, human genetics
MeSH terms
Animals, Crossing Over, Genetic, Biological Evolution, Female, Humans, Male, Mammals, Meiosis, Models, Genetic, Recombination, Genetic, Selection, Genetic, Sex Characteristics, Species Specificity, Linkage Disequilibrium, Genome, Human

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