An evolutionary view of human recombination
Abstract
Recombination has essential functions in mammalian meiosis, which impose several constraints on the recombination process. However, recent studies have shown that, in spite of these roles, recombination rates vary tremendously among humans, and show marked differences between humans and closely related species. These findings provide important insights into the determinants of recombination rates and raise new questions about the selective pressures that affect recombination over different genomic scales, with implications for human genetics and evolutionary biology.
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Short chromosomes have a higher recombination rate.
“because short chromosomes have a higher recombination rate 67”
From Genome analysis of the platypus reveals unique signatures of evolution (2008) · cites this paper as [67]
Selection for a recombination driver allele may be favored when it is tightly linked to two or more genes with alleles under selection.
“Specifically, selection for a recombination driver allele may be favored when it is tightly linked to two or more genes with alleles under selection (61).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [61]
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- Authors
- Coop, G., & Przeworski, M.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Przeworski, Molly
- Venue
- Nature Reviews Genetics
- Published
- 2006-12-05
- Volume
- 8
- Issue
- 1
- Pages
- 23-34
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2085231911
- Cited by
- 344
- References
- 143
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 53 · 2020: 10 · 2019: 14 · 2018: 13 · 2017: 25 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 12
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Chicago
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- meiotic recombination, recombination rate variation, mammalian meiosis, recombination hotspots, recombination rate evolution, comparative genomics, human genetics
- MeSH terms
- Animals, Crossing Over, Genetic, Biological Evolution, Female, Humans, Male, Mammals, Meiosis, Models, Genetic, Recombination, Genetic, Selection, Genetic, Sex Characteristics, Species Specificity, Linkage Disequilibrium, Genome, Human
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