The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation
Open accessAbstract
General anesthetics (GAs) have transformed surgery through their actions to depress the central nervous system and blunt the perception of surgical insults. Counterintuitively, many of these agents activate peripheral nociceptive neurons. However, the underlying mechanisms and significance of these effects have not been explored. Here, we show that clinical concentrations of noxious i.v. and inhalation GAs excite sensory neurons by selectively activating TRPA1, a key ion channel in the pain pathway. Further, these GAs induce pain-related responses in mice that are abolished in TRPA1-null animals. Significantly, TRPA1-dependent neurogenic inflammation is greater in mice anesthetized with pungent compared with nonpungent anesthetics. Thus, our results show that TRPA1 is essential for sensing noxious GAs. The pronociceptive effects of GAs combined with surgical tissue damage could lead to a paradoxical increase in postoperative pain and inflammation.
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Cites
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219
Cited by
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
Steinhoff, M. S., von Mentzer, B., Geppetti, P., Pothoulakis, C., & Bunnett, N. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00031.2013 · Cited by 628
When does acute pain become chronic?
Voscopoulos, C., & Lema, M. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq323 · Cited by 473
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent
Kilpatrick, G. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.690875 · Cited by 262
Metadata
- Authors
- Matta, J. A., Cornett, P. M., Miyares, R. L., Abe, K., Sahibzada, N., & Ahern, G. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-06-24
- Volume
- 105
- Issue
- 25
- Pages
- 8784-8789
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044911849
- Cited by
- 265
- References
- 1
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Matta, J. A., Cornett, P. M., Miyares, R. L., Abe, K., Sahibzada, N., & Ahern, G. P. (2008). General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711038105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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