The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation
Open accessAbstract
According to the amyloid hypothesis, the pathogenesis of Alzheimer's disease is triggered by the oligomerization and aggregation of the amyloid-β (Aβ) peptide into protein plaques. Formation of the potentially toxic oligomeric and fibrillar Aβ assemblies is accompanied by a conformational change toward a high content of β-structure. Here, we report the solution structure of Aβ(1–40) in complex with the phage-display selected affibody protein Z Aβ3 , a binding protein of nanomolar affinity. Bound Aβ(1–40) features a β-hairpin comprising residues 17–36, providing the first high-resolution structure of Aβ in β conformation. The positions of the secondary structure elements strongly resemble those observed for fibrillar Aβ. Z Aβ3 stabilizes the β-sheet by extending it intermolecularly and by burying both of the mostly nonpolar faces of the Aβ hairpin within a large hydrophobic tunnel-like cavity. Consequently, Z Aβ3 acts as a stoichiometric inhibitor of Aβ fibrillation. The selected Aβ conformation allows us to suggest a structural mechanism for amyloid formation based on soluble oligomeric hairpin intermediates.
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Cites
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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
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Protein backbone angle restraints from searching a database for chemical shift and sequence homology
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Cited by
Peptide-Based Vaccines: Current Progress and Future Challenges
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Antiparallel β-sheet: a signature structure of the oligomeric amyloid β-peptide
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Affibody Molecules in Biotechnological and Medical Applications
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Self-citationStabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering
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Self-citationAffibody molecules as engineered protein drugs
Frejd, F. Y., & Kim, K.-T. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.35 · Cited by 225
Metadata
- Authors
- Hoyer, W., Grönwall, C., Jonsson, A., Ståhl, S., & Härd, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-04
- Volume
- 105
- Issue
- 13
- Pages
- 5099-5104
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166848357
- Cited by
- 410
- References
- 11
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Hoyer, W., Grönwall, C., Jonsson, A., Ståhl, S., & Härd, T. (2008). Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711731105
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