Cited by 602Chemical Synthesis and Analysisvaccines and immunoinformatics approachesImmunotherapy and Immune Responses

Peptide-Based Vaccines: Current Progress and Future Challenges

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Malonis, Ryan J., Lai, Jonathan R., Vergnolle, Olivia·2020·Chemical Reviews

Abstract

Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.

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  • Synthetic peptides enable development of vaccine candidates that create a specific protective immune response by stimulating cellular and humoral immunity with B and T cell epitopes.

    “Synthetic peptides have proven to be a valuable tool for investigating the binding capacities, proteolytic activities and immunogenicity properties of proteins, enabling the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes.588”

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Authors
Malonis, R. J., Lai, J. R., & Vergnolle, O.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Lai, Jonathan R.
Venue
Chemical Reviews
Published
2019-12-05
Volume
120
Issue
6
Pages
3210-3229
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W2992070886
Cited by
602
References
180
Citations by year
2026: 47 · 2025: 96 · 2024: 106 · 2023: 129 · 2022: 100 · 2021: 92 · 2020: 32
FWCI
4.93
Type
journal article
Language
en
Open access
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R01-AI125462, R01-AI132256, R42-AI122403)
  • Irma T. Hirschl Trust
  • National Institute of General Medical Sciences (T32-GM007288)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
peptide vaccine, subunit vaccine, vaccine design, vaccine efficacy, infectious disease prevention, Alzheimer's disease, cancer vaccines, chronic disease prevention, antigenic determinants
MeSH terms
Alzheimer Disease, Animals, Humans, Neoplasms, Infection Control, Vaccines, Subunit

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