Peptide-Based Vaccines: Current Progress and Future Challenges
Open accessAbstract
Vaccines have had a profound impact on the management and prevention of infectious disease. In addition, the development of vaccines against chronic diseases has attracted considerable interest as an approach to prevent, rather than treat, conditions such as cancer, Alzheimer's disease, and others. Subunit vaccines consist of nongenetic components of the infectious agent or disease-related epitope. In this Review, we discuss peptide-based vaccines and their potential in three therapeutic areas: infectious disease, Alzheimer's disease, and cancer. We discuss factors that contribute to vaccine efficacy and how these parameters may potentially be modulated by design. We examine both clinically tested vaccines as well as nascent approaches and explore current challenges and potential remedies. While peptide vaccines hold substantial promise in the prevention of human disease, many obstacles remain that have hampered their clinical use; thus, continued research efforts to address these challenges are warranted.
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Synthetic peptides enable development of vaccine candidates that create a specific protective immune response by stimulating cellular and humoral immunity with B and T cell epitopes.
“Synthetic peptides have proven to be a valuable tool for investigating the binding capacities, proteolytic activities and immunogenicity properties of proteins, enabling the development of vaccine candidates that can create a specific protective immune response by stimulating both cellular and humoral immunity with the B and T cell epitopes.588”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [588]
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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
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Targeting aging and age-related diseases with vaccines
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- Authors
- Malonis, R. J., Lai, J. R., & Vergnolle, O.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Lai, Jonathan R.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-12-05
- Volume
- 120
- Issue
- 6
- Pages
- 3210-3229
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC7094793
- OpenAlex
- W2992070886
- Cited by
- 602
- References
- 180
- Citations by year
- 2026: 47 · 2025: 96 · 2024: 106 · 2023: 129 · 2022: 100 · 2021: 92 · 2020: 32
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01-AI125462, R01-AI132256, R42-AI122403)
- Irma T. Hirschl Trust
- National Institute of General Medical Sciences (T32-GM007288)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- peptide vaccine, subunit vaccine, vaccine design, vaccine efficacy, infectious disease prevention, Alzheimer's disease, cancer vaccines, chronic disease prevention, antigenic determinants
- MeSH terms
- Alzheimer Disease, Animals, Humans, Neoplasms, Infection Control, Vaccines, Subunit
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