The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition
Open accessAbstract
Under conditions of starvation and disease, the gut barrier becomes impaired, and trophic feeding to prevent gut mucosal atrophy has become a standard treatment of critically ill patients. However, the mechanisms responsible for the beneficial effects of enteral nutrition have remained a mystery. Using in vitro and in vivo models, we demonstrate that the brush–border enzyme, intestinal alkaline phosphatase (IAP), has the ability to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier. IAP expression and function are lost with starvation and maintained by enteral feeding. It is likely that the IAP silencing that occurs during starvation is a key component of the gut mucosal barrier dysfunction seen in critically ill patients.
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McCracken, V. J., & Lorenz, R. G. (2001) · Cellular Microbiology · doi:10.1046/j.1462-5822.2001.00090.x · Cited by 314
Cited by
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949
Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia
Moreira, A. P. B., Texeira, T. F. S., Ferreira, A. B., do Carmo Gouveia Peluzio, M., & de Cássia Gonçalves Alfenas, R. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512001213 · Cited by 655
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Chu, H., & Mazmanian, S. K. (2013) · Nature Immunology · doi:10.1038/ni.2635 · Cited by 630
Exploring host–microbiota interactions in animal models and humans
Kostic, A. D., Howitt, M. R., & Garrett, W. S. (2013) · Genes & Development · doi:10.1101/gad.212522.112 · Cited by 494
Doig, G. S., Heighes, P. T., Simpson, F., Sweetman, E. A., & Davies, A. R. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1664-4 · Cited by 464
Metadata
- Authors
- Goldberg, R. F., Austen, W. G., Zhang, X., Munene, G., Mostafa, G., Biswas, S., McCormack, M., Eberlin, K. R., Nguyen, J. T., Tatlidede, H. S., Warren, H. S., Narisawa, S., Millán, J. L., & Hodin, R. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-03-04
- Volume
- 105
- Issue
- 9
- Pages
- 3551-3556
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2071108985
- Cited by
- 369
- References
- 1
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldberg, R. F., Austen, W. G., Zhang, X., Munene, G., Mostafa, G., Biswas, S., McCormack, M., Eberlin, K. R., Nguyen, J. T., Tatlidede, H. S., Warren, H. S., Narisawa, S., Millán, J. L., & Hodin, R. A. (2008). Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0712140105
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