WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
Open accessAbstract
Mitochondrial fission and trafficking to dendritic protrusions have been implicated in dendritic spine development. Here, we show that Wiskott–Aldrich syndrome protein (WASP)-family verprolin homologous protein 1 (WAVE1) controls depolarization-induced mitochondrial movement into dendritic spines and filopodia and regulates spine morphogenesis. Depolarization-induced degradation of the p35 regulatory subunit of cyclin-dependent kinase 5 (Cdk5), with the resultant decreased inhibitory phosphorylation on WAVE1, depend on NMDA receptor activation. Thus, WAVE1 dephosphorylation and activation are likely associated with mitochondrial redistribution and spine morphogenesis.
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In primary cultured neurons, WAVE1-mediated actin polymerization is involved in neuronal activity-induced mitochondrial trafficking and fission.
“In primary cultured neurons, WAVE1-mediated actin polymerization is involved in neuronal activity-induced mitochondrial trafficking and fission45 (Fig. 4a).”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [45]
The Results and Discussion support a role for WAVE1 in activity-induced mitochondrial trafficking to dendritic protrusions in cultured neurons. The Discussion describes mediation by WAVE1-dependent actin polymerization as likely, not established, and says depolarization-induced fission still occurred when WAVE1 expression was reduced. Page numbers are not available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIn primary cultured cortical neurons, repetitive depolarization by KCl induces WAVE1 dephosphorylation in an NMDA receptor-dependent manner.
“In primary cultured cortical neurons, repetitive depolarization by KCl induces WAVE1 dephosphorylation in an NMDA receptor-dependent manner45.”
From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [45]
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OPA1 requires mitofusin 1 to promote mitochondrial fusion
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Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
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Mammalian Dynamin-like Protein DLP1 Tubulates Membranes
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The WAVE complex in developmental and adulthood brain disorders
Kim, H.-G., Berdasco, C., Nairn, A. C., & Kim, Y. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01386-w · Cited by 8 · see citing works
Self-citation
- Authors
- Sung, J. Y., Engmann, O., Teylan, M. A., Nairn, A. C., Greengard, P., & Kim, Y.
- Affiliations
- Rockefeller University (US)
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-02-26
- Volume
- 105
- Issue
- 8
- Pages
- 3112-3116
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2268593
- OpenAlex
- W2163296768
- Cited by
- 117
- References
- 4
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 9
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- F. M. Kirby Foundation
- Fisher Center for Alzheimer's Research Foundation
- James N. Kirby Foundation
- National Institute on Aging (AG09464, P01AG009464)
- National Institute on Drug Abuse (DA10044, P01DA010044)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- WAVE1, dendritic spines, mitochondrial trafficking, mitochondrial fission, neuronal depolarization, filopodia, spine morphogenesis, NMDA receptor, Wiskott-Aldrich syndrome protein, neuronal activity, dendritic protrusions
- MeSH terms
- Animals, Hippocampus, Image Processing, Computer-Assisted, Microscopy, Fluorescence, Mitochondria, Phosphorylation, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, RNA Interference, Dendritic Spines, Wiskott-Aldrich Syndrome Protein Family, Rats
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