The influence of synaptic activity on neuronal health

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498 · see citing works

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

Wang, X., & Schwarz, T. L. (2009) · Cell · doi:10.1016/j.cell.2008.11.046 · Cited by 871 · see citing works

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

MacAskill, A. F., Rinholm, J. E., Twelvetrees, A. E., Arancibia‐Cárcamo, I. L., Muir, J., Fransson, Å., Aspenström, P., Attwell, D., & Kittler, J. T. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.030 · Cited by 677 · see citing works

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Tashiro, A., Sandler, V. M., Toni, N., Zhao, C., & Gage, F. H. (2006) · Nature · doi:10.1038/nature05028 · Cited by 620 · see citing works

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

D'Amelio, M., Cavallucci, V., Middei, S., Marchetti, C., Pacioni, S., Ferri, A., Diamantini, A., De Zio, D., Carrara, P., Battistini, L., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2709 · Cited by 572 · see citing works

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

Weydt, P., Pineda, V. V., Torrence, A. E., Libby, R. T., Satterfield, T. F., Lazarowski, E. R., Gilbert, M. L., Morton, G. J., Bammler, T. K., Strand, A. D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.004 · Cited by 562 · see citing works

Bidirectional Ca ²⁺ -dependent control of mitochondrial dynamics by the Miro GTPase

Saotome, M., Safiulina, D., Szabadkai, G., Das, S., Fransson, Å., Aspenstrom, P., Rizzuto, R., & Hajnóczky, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808953105 · Cited by 538 · see citing works

Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity

Hardingham, G. E., Arnold, F. J. L., & Bading, H. (2001) · Nature Neuroscience · doi:10.1038/85109 · Cited by 537 · see citing works

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

Li, Z., Jo, J., Jia, J., Lo, S., Whitcomb, D. J., Jiao, S., Cho, K., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.03.053 · Cited by 533 · see citing works

Caspase activation precedes and leads to tangles

de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., & Hyman, B. T. (2010) · Nature · doi:10.1038/nature08890 · Cited by 517 · see citing works

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Milnerwood, A. J., Gladding, C. M., Pouladi, M. A., Kaufman, A. M., Hines, R. M., Boyd, J. D., Ko, R. W. Y., Vasuta, O. C., Graham, R. K., Hayden, M. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.008 · Cited by 516 · see citing works

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498 · see citing works

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

Okamoto, S., Pouladi, M. A., Talantova, M. V., Yao, D., Xia, P., Ehrnhoefer, D. E., Zaidi, R., Clemente, A., Kaul, M., Graham, R. K., et al. (2009) · Nature Medicine · doi:10.1038/nm.2056 · Cited by 439 · see citing works

Mitochondrial Trafficking to Synapses in Cultured Primary Cortical Neurons

Chang, D. T. W., Honick, A. S., & Reynolds, I. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1012-06.2006 · Cited by 391 · see citing works

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

Xia, P., Chen, H.-S. V., Zhang, D., & Lipton, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-10.2010 · Cited by 380 · see citing works

Control of mitochondrial transport and localization in neurons

MacAskill, A. F., & Kittler, J. T. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.11.002 · Cited by 372 · see citing works

Brain‐Derived Neurotrophic Factor in Neuronal Survival and Behavior‐Related Plasticity

LIPSKY, R. H., & MARINI, A. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1403.009 · Cited by 361 · see citing works

Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade

Bruno, M. A., & Cuello, A. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510645103 · Cited by 344 · see citing works

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

Nishijima, T., Piriz, J., Duflot, S., Fernandez, A. M., Gaitán, G., Gómez‐Pinedo, U., García‐Verdugo, J. M., Leroy, F., Soya, H., Núñez, Á., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.007 · Cited by 335 · see citing works

Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons

Rintoul, G. L., Filiano, A. J., Brocard, J. B., Kress, G. J., & Reynolds, I. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07881.2003 · Cited by 326 · see citing works

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

Zhang, S., Zou, M., Lü, L., Lau, D., Ditzel, D. A. W., Delucinge-Vivier, C., Aso, Y., Descombes, P., & Bading, H. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000604 · Cited by 311 · see citing works

Drug‐induced Apoptotic Neurodegeneration in the Developing Brain

Olney, J. W., Wozniak, D. F., Jevtović‐Todorović, V., Farber, N. B., Bittigau, P., & Ikonomidou, C. (2002) · Brain Pathology · doi:10.1111/j.1750-3639.2002.tb00467.x · Cited by 295 · see citing works

PGC-1α and PGC-1Β Regulate Mitochondrial Density in Neurons

Warȩski, P., Vaarmann, A., Choubey, V., Safiulina, D., Liiv, J., Kuum, M., & Kaasik, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018911 · Cited by 294 · see citing works

Nuclear Ca2+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

Papadia, S., Stevenson, P., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-04.2005 · Cited by 262 · see citing works

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Hardingham, G. E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371147 · Cited by 260 · see citing works

Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

Soriano, F. X., Papadia, S., Hofmann, F., Hardingham, N. R., Bading, H., & Hardingham, G. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0455-06.2006 · Cited by 236 · see citing works

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production

Bordji, K., Becerril-Ortega, J., Nicole, O., & Buisson, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3021-10.2010 · Cited by 195 · see citing works

Neuronal death enhanced by N -methyl- d -aspartate antagonists

Ikonomidou, C., Stefovska, V. G., & Turski, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220412197 · Cited by 188 · see citing works

Synapse-Associated Protein-97 Mediates α-Secretase ADAM10 Trafficking and Promotes Its Activity

Marcello, E. E., Gardoni, F., Mauceri, D., Romorini, S., Jeromin, A., Epis, R., Borroni, B., Cattabeni, F., Sala, C., Padovani, A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3439-06.2007 · Cited by 186 · see citing works

Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production

Hoey, S. E., Williams, R. J., & Perkinton, M. S. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.6017-08.2009 · Cited by 178 · see citing works

Activity-Dependent Neuroprotection and cAMP Response Element-Binding Protein (CREB): Kinase Coupling, Stimulus Intensity, and Temporal Regulation of CREB Phosphorylation at Serine 133

Lee, B., Butcher, G. Q., Hoyt, K. R., Impey, S., & Obrietan, K. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4288-04.2005 · Cited by 165 · see citing works

Effects of Synaptic Modulation on β-Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

Tampellini, D., Capetillo‐Zarate, E., Dumont, M., Huang, Z., Yu, F., Lin, M. T. S., & Gouras, G. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3383-10.2010 · Cited by 161 · see citing works

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

Léveillé, F., Papadia, S., Fricker, M., Bell, K. F. S., Soriano, F. X., Martel, M., Puddifoot, C. A., Habel, M., Wyllie, D. J. A., Ikonomidou, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5115-09.2010 · Cited by 145 · see citing works

Transcorneal Electrical Stimulation Promotes the Survival of Photoreceptors and Preserves Retinal Function in Royal College of Surgeons Rats

Morimoto, T., Fujikado, T., Choi, J., Kanda, H., Miyoshi, T., Fukuda, Y., & Tano, Y. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1404 · Cited by 132 · see citing works

ADP Regulates Movements of Mitochondria in Neurons

Mironov, S. L. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.092981 · Cited by 129 · see citing works

Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations

Tampellini, D., Rahman, N., Gallo, E. F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D. M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2292-09.2009 · Cited by 127 · see citing works

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

Kong, Y., Ruan, L., Qian, L., Liu, X., & Le, Y. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2985-10.2010 · Cited by 127 · see citing works

Neural Activity and Survival in the Developing Nervous System

Zorumski, C. F., & Mennerick, S. J. (2000) · Molecular Neurobiology · doi:10.1385/mn:22:1-3:041 · Cited by 126 · see citing works

WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines

Sung, J. Y., Engmann, O., Teylan, M. A., Nairn, A. C., Greengard, P., & Kim, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712180105 · Cited by 117 · see citing works

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells*

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 108 · see citing works

Pro-survival signalling from the NMDA receptor

Hardingham, G. E. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340936 · Cited by 100 · see citing works

Synaptic Activity and Nuclear Calcium Signaling Protect Hippocampal Neurons from Death Signal-associated Nuclear Translocation of FoxO3a Induced by Extrasynaptic N-Methyl-d-aspartate Receptors

Dick, O., & Bading, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.127654 · Cited by 88 · see citing works

Increased Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in the Rat Cerebellum After Exposure to Environmental Enrichment

Angelucci, F., Bartolo, P. D., Gelfo, F., Foti, F., Cutuli, D., Bossù, P., Caltagirone, C., & Petrosini, L. (2009) · The Cerebellum · doi:10.1007/s12311-009-0129-1 · Cited by 88 · see citing works

Synaptic Activity-Mediated Suppression of p53 and Induction of Nuclear Calcium-Regulated Neuroprotective Genes Promote Survival through Inhibition of Mitochondrial Permeability Transition

Lau, D., & Bading, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0802-09.2009 · Cited by 82 · see citing works

Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene

Mubarak, B. R. A., Soriano, F. X., & Hardingham, G. E. (2009) · Channels · doi:10.4161/chan.3.4.9381 · Cited by 82 · see citing works

Exercise-Induced Activation of NMDA Receptor Promotes Motor Unit Development and Survival in a Type 2 Spinal Muscular Atrophy Model Mouse

Biondi, O., Grondard, C., Lécolle, S., Deforges, S., Pariset, C. C., Lopes, P., Cifuentes-Díaz, C., Li, H., Gaspera, B. D., Chanoine, C., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3237-07.2008 · Cited by 74 · see citing works

On neuronal health

Ole Isacson, A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90104-t · Cited by 72 · see citing works

Nuclear Factor of Activated T-Cells Isoform c4 (NFATc4/NFAT3) as a Mediator of Antiapoptotic Transcription in NMDA Receptor-Stimulated Cortical Neurons

Vashishta, A., Habas, A., Pruunsild, P., Zheng, J., Timmusk, T., & Hetman, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4873-09.2009 · Cited by 69 · see citing works

Compartmentalized NMDA receptor signalling to survival and death

Soriano, F. X., & Hardingham, G. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.138875 · Cited by 65 · see citing works

Retinal Expression ofFgf2in RCS Rats with Subretinal Microphotodiode Array

Ciavatta, V. T., Kim, M., WONG, P. W. K., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2072 · Cited by 61 · see citing works

Neuroprotection for optic nerve disorders

Bessero, A. –., & Clarke, P. G. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283344461 · Cited by 59 · see citing works

Nuclear Ca2+ and CaM kinase IV specify hormonal‐ and Notch‐responsiveness

McKenzie, G. J., Stevenson, P., Ward, G. A., Papadia, S., Bading, H., Chawla, S., Privalsky, M. L., & Hardingham, G. E. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03010.x · Cited by 55 · see citing works

Electrical activity enhances neuronal survival and regeneration

Corredor, R. G., & Goldberg, J. L. (2009) · Journal of Neural Engineering · doi:10.1088/1741-2560/6/5/055001 · Cited by 51 · see citing works

NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice

Zheng, S., Eacker, S. M., Hong, S. J., Gronostajski, R. M., Dawson, T. M., & Dawson, V. L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci33144 · Cited by 49 · see citing works

In VivoNMDA Receptor Activation Accelerates Motor Unit Maturation, Protects Spinal Motor Neurons, and Enhances SMN2 Gene Expression in Severe Spinal Muscular Atrophy Mice

Biondi, O., Branchu, J., Sanchez, G., Lancelin, C., Deforges, S., Lopes, P., Pariset, C. C., Lécolle, S., Côté, J., Chanoine, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1764-10.2010 · Cited by 49 · see citing works

Elevated Synaptic Activity Preconditions Neurons against an in Vitro Model of Ischemia

Tauskela, J. S., Fang, H., Hewitt, M., Brunette, E., Ahuja, T. K., Thivierge, J., Comas, T., & Mealing, G. A. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805624200 · Cited by 49 · see citing works

Postsynaptic Alteration of NR2A Subunit and Defective Autophosphorylation of alphaCaMKII at Threonine-286 Contribute to Abnormal Plasticity and Morphology of Upper Motor Neurons in Presymptomatic SOD1G93A Mice, a Murine Model for Amyotrophic Lateral Sclerosis

Spalloni, A., Origlia, N., Sgobio, C., Trabalza, A., Nutini, M., Berretta, N., Bernardi, G., Domenici, L., Ammassari‐Teule, M., & Longone, P. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq152 · Cited by 35 · see citing works

Action Potentials: To the Nucleus and Beyond

Saha, R. N., & Dudek, S. M. (2008) · Experimental Biology and Medicine · doi:10.3181/0709-mr-241 · Cited by 31 · see citing works

Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses

Soriano, F. X., Léveillé, F., Papadia, S., Bell, K. F. S., Puddifoot, C. A., & Hardingham, G. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3568 · Cited by 24 · see citing works

γ‐secretase complexes containing caspase‐cleaved presenilin‐1 increase intracellular Aβ42/Aβ40 ratio

Hedskog, L., Petersen, C. H., Svensson, A., Welander, H., Tjernberg, L. O., Karlström, H., & Ankarcrona, M. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01208.x · Cited by 10 · see citing works

Active cortical innervation protects striatal neurons from slow degeneration in culture

Fishbein, I., & Segal, M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0505-5 · Cited by 5 · see citing works

The ageing cortical synapse: hallmarks and implications for cognitive decline

Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Baxter, P. S., Bell, K. F. S., Hasel, P., Kaindl, A. M., Fricker, M., Thomson, D., Cregan, S. P., Gillingwater, T. H., & Hardingham, G. E. (2015) · Nature Communications · doi:10.1038/ncomms7761 · Cited by 139 · see citing works

Modulation of apoptosis controls inhibitory interneuron number in the cortex

Denaxa, M., Neves, G., Rabinowitz, A., Kemlo, S., Liodis, P., Burrone, J., & Pachnis, V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.064 · Cited by 112 · see citing works

Gain insight into managing a dysfunctional manager

McCarthy, C. (2016) · The Successful Registrar · doi:10.1002/tsr.30248

Gain insight into managing a dysfunctional manager

McCarthy, C. (2016) · College Athletics and the Law · doi:10.1002/catl.30251

Gain insight into managing a dysfunctional manager

McCarthy, C. (2016) · Student Affairs Today · doi:10.1002/say.30245

Providing Social and Psychological Support to Dysfunctional Families in Regions

Корчагина, Л. М. (2021) · Психолого-педагогический поиск · doi:10.37724/rsu.2021.58.2.013 · Cited by 1 · see citing works

THE IMPACT OF DYSFUNCTIONAL FAMILY ON ADULT CHILD PORTRAYED IN MY NAME IS LUCY BARTON

Andhika, A. L. (2021) · Elite English and Literature Journal · doi:10.24252/10.24252/elite.v8i1a2 · Cited by 1 · see citing works