The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Human receptors for sweet and umami taste
Open accessAbstract
The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners. In contrast, human T1R1/T1R3 responds to the umami taste stimulus l -glutamate, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste. The ligand specificities of rat T1R2/T1R3 and T1R1/T1R3 correspond to those of their human counterparts. These findings implicate the T1Rs in umami taste and suggest that sweet and umami taste receptors share a common subunit.
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Cites
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Cited by
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995
Common sense about taste: from mammals to insects
Yarmolinsky, D. A., Zuker, C. S., & Ryba, N. J. P. (2009) · Cell · doi:10.1016/j.cell.2009.10.001 · Cited by 856
T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
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Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003) · Science · doi:10.1126/science.1087155 · Cited by 632
Metadata
- Authors
- Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., & Adler, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-03-26
- Volume
- 99
- Issue
- 7
- Pages
- 4692-4696
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2122060463
- Cited by
- 1,378
- References
- 25
- FWCI
- 42.41
- Type
- journal article
- Language
- en
- Open access
- green
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