The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
Abstract
The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors. Here,we show that mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and nerve responses to sugars and umami compounds. These results indicate that T1r3-independent sweet- and umami-responsive receptors and/or pathways exist in taste cells.
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Cites
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Human receptors for sweet and umami taste
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A metabotropic glutamate receptor variant functions as a taste receptor
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Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
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Self-citationA candidate taste receptor gene near a sweet taste locus
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Cited by
Nutrient-sensing mechanisms and pathways
Efeyan, A., Comb, W. C., & Sabatini, D. M. (2015) · Nature · doi:10.1038/nature14190 · Cited by 1,110
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
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Self-citationCommon sense about taste: from mammals to insects
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T1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
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Self-citationGlucose Sensing in L Cells: A Primary Cell Study
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Metadata
- Authors
- Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F.
- Venue
- Science
- Published
- 2003-08-08
- Volume
- 301
- Issue
- 5634
- Pages
- 850-853
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020053294
- Cited by
- 632
- References
- 14
- FWCI
- 20.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., & Margolskee, R. F. (2003). Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3. Science. https://doi.org/10.1126/science.1087155
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