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Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)
Open accessAbstract
Primordial germ cells (PGCs) are the founders of sperm or oocytes. PGCs migrate through the tissues of the embryos and colonize the gonads during development. However, the cytokines essential for colonization of the gonads by PGCs in mammals remain unclear. Stromal cell-derived factor-1 (SDF-1, also called PBSF and CXCL12) is a member of chemokines, a family of structurally related chemoattractive cytokines. SDF-1 and its primary physiologic receptor CXCR4 have multiple essential functions in development including colonization of bone marrow by hematopoietic cells and neuron localization within cerebellum during embryogenesis as well as B lymphopoiesis and cardiovasculogenesis. Here, we have shown that PGCs have cell-surface expression of CXCR4 and that, in SDF-1 −/− mice, PGCs undergo directed migration through tissues of embryos, but the numbers of PGCs in the gonads are significantly reduced. The proliferation of PGCs within the gonads seems normal in the mutant mice. These findings reveal the essential role for SDF-1 in murine PGC development likely by controlling colonization of the gonads by PGCs.
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Cited by
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska‐Wieczorek, A., Ratajczak, J., & Ratajczak, M. Z. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0342 · Cited by 759
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Shi, M., Li, J., Liao, L., Chen, B., Li, B., Chen, L., Jia, H., & Zhao, R. C. (2007) · Haematologica · doi:10.3324/haematol.10669 · Cited by 339
Molecular and epigenetic pathogenesis of germ cell tumors
Müller, M. R., Skowron, M. A., Albers, P., & Nettersheim, D. (2021) · Asian Journal of Urology · doi:10.1016/j.ajur.2020.05.009 · Cited by 50
Tumor-stroma interactions in tumorigenesis lessons from stem cell biology
Friedrich, K. (2012) · Frontiers in Bioscience · doi:10.2741/e509 · Cited by 10
Metadata
- Authors
- Ara, T., Nakamura, Y., Egawa, T., Sugiyama, T., Abe, K., Kishimoto, T., Matsui, Y., & Nagasawa, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-04-08
- Volume
- 100
- Issue
- 9
- Pages
- 5319-5323
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046197443
- Cited by
- 328
- References
- 0
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Ara, T., Nakamura, Y., Egawa, T., Sugiyama, T., Abe, K., Kishimoto, T., Matsui, Y., & Nagasawa, T. (2003). Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0730719100
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