The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Molecular imaging of proteins in tissues by mass spectrometry
Open accessAbstract
Imaging MS (IMS) is an emerging technology that permits the direct analysis and determination of the distribution of molecules in tissue sections. Biological molecules such as proteins, peptides, lipids, xenobiotics, and metabolites can be analyzed in a high-throughput manner with molecular specificity not readily achievable through other means. Tissues are analyzed intact and thus spatial localization of molecules within a tissue is preserved. Several studies are presented that focus on the unique types of information obtainable by IMS, such as Aβ isoform distributions in Alzheimer's plaques, protein maps in mouse brain, and spatial protein distributions in human breast carcinoma. The analysis of a biopsy taken 100 years ago from a patient with amyloidosis illustrates the use of IMS with formalin-fixed tissues. Finally, the registration and correlation of IMS with MRI is presented.
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Cites
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
Self-citationMatrix-assisted laser desorption/ionization mass spectrometry of biopolymers.
Hillenkamp, F., Karas, M., Beavis, R. C., & Chait, B. T. (1991) · Analytical Chemistry · doi:10.1021/ac00024a716 · Cited by 1,930
Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging
Sinha, T. K., Khatib-Shahidi, S., Yankeelov, T. E., Mapara, K., Ehtesham, M., Cornett, D. S., Dawant, B. M., Caprioli, R. M., & Gore, J. C. (2008) · Nature Methods · doi:10.1038/nmeth1147 · Cited by 168
Self-citation
Cited by
MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives
Seeley, E. H., & Caprioli, R. M. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2010.12.002 · Cited by 197
Self-citationComprehensive comparison of large-scale tissue expression datasets
Santos, A., Tsafou, K., Stolte, C., Pletscher-Frankild, S., O’Donoghue, S. I., & Jensen, L. J. (2015) · PeerJ · doi:10.7717/peerj.1054 · Cited by 92
Körber, A., Anthony, I. G. M., & Heeren, R. M. A. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05249 · Cited by 88
Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data
Abdelmoula, W. M., Regan, M. S., Lopez, B. G. C., Randall, E. C., Lawler, S., Mladek, A. C., Nowicki, M. O., Marin, B. M., Agar, J. N., Swanson, K. R., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00854 · Cited by 62
Anerillas, C., Altés, G., Gresova, K., Tsitsipatis, D., Mazan-Mamczarz, K., Banarjee, R., Cunningham, A. S. G., Salamini-Montemurri, M., Yang, J.-H., Munk, R., et al. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.05.017 · Cited by 11
Metadata
- Authors
- Seeley, E. H., & Caprioli, R. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-11-25
- Volume
- 105
- Issue
- 47
- Pages
- 18126-18131
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102860297
- Cited by
- 303
- References
- 3
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- green
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