The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
Open accessAbstract
The autonomic nervous system maintains homeostasis through its sympathetic and parasympathetic divisions. During infection, cells of the immune system release cytokines and other mediators that cause fever, hypotension, and tissue injury. Although the effect of cytokines on the nervous system has been known for decades, only recently has it become evident that the autonomic nervous system, in turn, regulates cytokine production through neural pathways. We have previously shown that efferent vagus nerve signals regulate cytokine production through the nicotinic acetylcholine receptor subunit α7, a mechanism termed “the cholinergic antiinflammatory pathway.” Here, we show that vagus nerve stimulation during endotoxemia specifically attenuates TNF production by spleen macrophages in the red pulp and the marginal zone. Administration of nicotine, a pharmacological agonist of α7, attenuated TNF immunoreactivity in these specific macrophage subpopulations. Synaptophysin-positive nerve endings were observed in close apposition to red pulp macrophages, but they do not express choline acetyltransferase or vesicular acetylcholine transporter. Surgical ablation of the splenic nerve and catecholamine depletion by reserpine indicate that these nerves are catecholaminergic and are required for functional inhibition of TNF production by vagus nerve stimulation. Thus, the cholinergic antiinflammatory pathway regulates TNF production in discrete macrophage populations via two serially connected neurons: one preganglionic, originating in the dorsal motor nucleus of the vagus nerve, and the second postganglionic, originating in the celiac-superior mesenteric plexus, and projecting in the splenic nerve.
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Cites
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citationNicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228
Self-citationPoints of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · cited 2×
“Discussion The results herein expand our knowledge of the anatomical basis of the cholinergic antiinflammatory pathway (28, 29).”
BackgroundSelf-citationHuston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052362 · Cited by 683 · cited 4×
“Vagus nerve stimulation was performed as described previously (12).”
BackgroundMethodInfluentialSelf-citationTransdermal Nicotine for Active Ulcerative Colitis
Pullan, R. D., Rhodes, J., Ganesh, S., Mani, V., Morris, J. S., Williams, G. T., Newcombe, R. G., Russell, M., Feyerabend, C., Thomas, G., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403243301202 · Cited by 505 · cited 1×
“Activation of the cholinergic antiinflammatory pathway, either by electrical stimulation of the vagus nerve or through pharmacological approaches, has been shown to significantly ameliorate cytokine-mediated disease models, including endotoxemia (2, 6), sepsis (6, 7), colitis (8), pancreatitis (9), and ischemia reperf…”
BackgroundThe Vagus Nerve and Nicotinic Receptors Modulate Experimental Pancreatitis Severity in Mice
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Self-citationCano, G., Sved, A. F., Rinaman, L., Rabin, B. S., & Card, J. P. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1331 · Cited by 237
Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Susarla, S., Czura, C. J., & Tracey, K. J. (2002) · Journal of Vascular Surgery · doi:10.1067/mva.2002.129643 · Cited by 228
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Cited by
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551
Self-citationTracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154
Self-citationNeuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040
Self-citationSepsis: a roadmap for future research
Cohen, J., Vincent, J.-L., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S., Delaloye, J., Opal, S., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 992
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Metadata
- Authors
- Rosas-Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y. T., Huston, J. M., Chavan, S., & Tracey, K. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-08-05
- Volume
- 105
- Issue
- 31
- Pages
- 11008-11013
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046775696
- Cited by
- 753
- References
- 10
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Rosas-Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y. T., Huston, J. M., Chavan, S., & Tracey, K. J. (2008). Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0803237105
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