The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex
Open accessAbstract
In the prefrontal cortex, NMDA receptors are important for normal prefrontal functions such as working memory, and their dysfunction plays a key role in the pathological processes of psychiatric disorders such as schizophrenia. Little is known, however, about the synaptic properties of NMDA receptors in the local circuits of recurrent excitation, a leading candidate mechanism underlying working memory. We investigated the NMDA receptor-mediated currents at monosynaptic connections between pairs of layer 5 pyramidal neurons. We found that NMDA receptor-mediated currents at prefrontal synapses in the adult, but not young, rats exhibit a twofold longer decay time-constant and temporally summate a train of stimuli more effectively, compared to those in the primary visual cortex. Experiments with pharmacological, immunocytochemical, and biochemical approaches further suggest that, in the adult animals, neurons express significantly more NR2B subunits in the prefrontal cortex than the visual cortex. The NR2B-rich synapses in the prefrontal circuitry may be critically implicated in online cognitive computations and plasticity in learning, as well as psychiatric disorders.
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“Further, NMDA-mediated current does not change across adolescence in layer 5 pyramidal neurons in rat frontal cortex (Wang et al., 2008).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Wang et al., 2008
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Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
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A hierarchy of intrinsic timescales across primate cortex
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Metadata
- Authors
- Wang, H., Stradtman, G. G., Wang, X.-J., & Gao, W.-J.
- Affiliations
- Drexel University (US)
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-10-28
- Volume
- 105
- Issue
- 43
- Pages
- 16791-16796
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2575498
- OpenAlex
- W2064286037
- Cited by
- 199
- References
- 39
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 16 · 2015: 14 · 2014: 20 · 2013: 17 · 2012: 11
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Drexel University
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (NIH-R01)
- College of Medicine, Drexel University
- National Institute of Mental Health (R21MH079117, R01MH062349, MH232307, R01MH085666)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- NMDA receptor, prefrontal cortex, layer 5 pyramidal neurons, monosynaptic connections, NR2B subunit, synaptic plasticity, working memory, temporal summation, primary visual cortex, schizophrenia, adult rats
- MeSH terms
- Animals, Synaptic Transmission, Synapses, Receptors, N-Methyl-D-Aspartate, Prefrontal Cortex, Pyramidal Cells, Rats
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