A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex

An Integrative Theory of Prefrontal Cortex Function

Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685

Cellular basis of working memory

Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663

Neuron Activity Related to Short-Term Memory

Fuster, J. M., & Alexander, G. E. (1971) · Science · doi:10.1126/science.173.3997.652 · Cited by 2,085

Genetic enhancement of learning and memory in mice

Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,878

NMDA receptor subunits: diversity, development and disease

Cull-Candy, S., Brickley, S., & Farrant, M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00215-4 · Cited by 1,694

Neural Mechanisms of Visual Working Memory in Prefrontal Cortex of the Macaque

Miller, E. K., Erickson, C. A., & Desimone, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05154.1996 · Cited by 1,474

Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells

Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 1,385

Synaptic theory of working memory

Mongillo, G., Barak, O., & Tsodyks, M. (2008) · Science · doi:10.1126/science.1150769 · Cited by 1,253

Synaptic Mechanisms and Network Dynamics Underlying Spatial Working Memory in a Cortical Network Model

Compte, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.9.910 · Cited by 1,143

Synaptic reverberation underlying mnemonic persistent activity

Wang, X.-J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01868-3 · Cited by 1,059

Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory

Wang, X.-J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09587.1999 · Cited by 859

Neuronal correlates of parametric working memory in the prefrontal cortex

Romo, R., Brody, C. D., Hernández, A., & Lemus, L. (1999) · Nature · doi:10.1038/20939 · Cited by 822

Neurocomputational models of working memory

Durstewitz, D., Seamans, J. K., & B, T. J. S. A. (2000) · Nature Neuroscience · doi:10.1038/81460 · Cited by 729

Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons

Magee, J. C., & Cook, E. P. (2000) · Nature Neuroscience · doi:10.1038/78800 · Cited by 637

The Yin and Yang of NMDA receptor signalling

Hardingham, G. E., & Bading, H. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00040-1 · Cited by 634

NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex

Flint, A. C., Maisch, U. S., Weishaupt, J. H., Kriegstein, A. R., & Monyer, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02469.1997 · Cited by 623

Roles of NMDA NR2B Subtype Receptor in Prefrontal Long-Term Potentiation and Contextual Fear Memory

Zhao, M., Toyoda, H., Lee, Y., Wu, L., Ko, S. W., Zhang, X.-H., Jia, Y., Shum, F. W. F., Xu, H., Li, B.-M., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.014 · Cited by 509

Heterogeneity in the pyramidal network of the medial prefrontal cortex

Wang, Y., Markram, H., Goodman, P. H., Berger, T. K., Ma, J., & Goldman-Rakic, P. S. (2006) · Nature Neuroscience · doi:10.1038/nn1670 · Cited by 503

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

Verma, A., & Moghaddam, B. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00373.1996 · Cited by 451

Cortex, Cognition and the Cell: New Insights into the Pyramidal Neuron and Prefrontal Function

Elston, G. N. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg093 · Cited by 440

A role for NMDA-receptor channels in working memory

Lisman, J. E., Fellous, J., & Wang, X. (1998) · Nature Neuroscience · doi:10.1038/1086 · Cited by 438

Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles

Erreger, K., Dravid, S. M., Banke, T. G., Wyllie, D. J. A., & Traynelis, S. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080028 · Cited by 421

Bidirectional, experience-dependent regulation of N- methyl- d -aspartate receptor subunit composition in the rat visual cortex during postnatal development

Quinlan, E. M., Olstein, D. H., & Bear, M. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12876 · Cited by 382

Firing characteristics of deep layer neurons in prefrontal cortex in rats performing spatial working memory tasks

Jung, M. W., Qin, Y. F., McNaughton, B. L., & Barnes, C. A. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.5.437 · Cited by 318

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits

Gao, W.-J., Krimer, L. S., & Goldman-Rakic, P. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.295 · Cited by 257

Multiple Forms of Short-Term Plasticity at Excitatory Synapses in Rat Medial Prefrontal Cortex

Hempel, C. M., Hartman, K. H., Wang, X.-J., Turrigiano, G. G., & Nelson, S. B. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.3031 · Cited by 229

The NMDA-to-AMPA Ratio at Synapses Onto Layer 2/3 Pyramidal Neurons Is Conserved Across Prefrontal and Visual Cortices

Myme, C. I. O., Sugino, K., Turrigiano, G. G., & Nelson, S. B. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00070.2003 · Cited by 219

NR2B-Containing Receptors Mediate Cross Talk among Hippocampal Synapses

Scimemi, A., Fine, A., Kullmann, D. M., & Rusakov, D. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-04.2004 · Cited by 198

Separable features of visual cortical plasticity revealed by N -methyl- d -aspartate receptor 2A signaling

Fagiolini, M., Katagiri, H., Miyamoto, H., Mori, H., Grant, S. G. N., Mishina, M., & Hensch, T. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536089100 · Cited by 178

Enhanced NR2A Subunit Expression and Decreased NMDA Receptor Decay Time at the Onset of Ocular Dominance Plasticity in the Ferret

Roberts, E. B., & Ramoa, A. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.5.2587 · Cited by 150

Two Forms of Synaptic Plasticity with Distinct Dependence on Age, Experience, and NMDA Receptor Subtype in Rat Visual Cortex

Yoshimura, Y., Ohmura, T., & Komatsu, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06557.2003 · Cited by 120

Decline of the Critical Period of Visual Plasticity Is Concurrent with the Reduction of NR2B Subunit of the Synaptic NMDA Receptor in Layer 4

Erisir, A., & Harris, J. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05208.2003 · Cited by 111

NMDA and AMPA receptors on neocortical neurons are differentially distributed

Dodt, H., Frick, A., Kampe, K. K. W., & Zieglgänsberger, W. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00338.x · Cited by 96

Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex

Gonzalez-Burgos, G., Kroener, S., Zaitsev, A. V., Povysheva, N. V., Krimer, L. S., Barrionuevo, G., & Lewis, D. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm095 · Cited by 95

Hallucinogen-Induced UP States in the Brain Slice of Rat Prefrontal Cortex: Role of Glutamate Spillover and NR2B-NMDA Receptors

Lambe, E. K., & Aghajanian, G. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300944 · Cited by 75

Fast NMDA Receptor–Mediated Synaptic Currents in Neurons From Mice Lacking the ε2 (NR2B) Subunit

Tovar, K. R., Sprouffske, K., & Westbrook, G. L. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.1.616 · Cited by 70

Expression of N-Methyl-D-Aspartate receptor subunit mRNAs in the human brain: Striatum and globus pallidus

Kosinski, C. M., Standaert, D. G., Counihan, T. J., Scherzer, C. R., Kerner, J. A., Daggett, L. P., Veli�elebi, G., Penney, J. B., Young, A. B., & Landwehrmeyer, G. B. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980105)390:1 · Cited by 62

Blockade of NMDA receptors located at the dorsomedial prefrontal cortex impairs spatial working memory in rats

Aura, J., & Riekkinen, P. (1999) · Neuroreport · doi:10.1097/00001756-199902050-00008 · Cited by 55

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

Wang, X.-J. (2010) · Physiological Reviews · doi:10.1152/physrev.00035.2008 · Cited by 1,939

A hierarchy of intrinsic timescales across primate cortex

Murray, J. D., Bernacchia, A., Freedman, D. J., Romo, R., Wallis, J. D., Cai, X., Padoa-Schioppa, C., Pasternak, T., Seo, H., Lee, D., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3862 · Cited by 990

Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology

Sydnor, V. J., Larsen, B., Bassett, D. S., Alexander‐Bloch, A. F., Fair, D. A., Liston, C. M., Mackey, A. P., Milham, M. P., Pines, A. R., Roalf, D. R., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.016 · Cited by 750

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

Burt, J. B., Demirtaş, M., Eckner, W. J., Navejar, N. M., Ji, J. L., Martin, W. J., Bernacchia, A., Anticevic, A., & Murray, J. D. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0195-0 · Cited by 657

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489

NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders

Monaco, S. A., Gulchina, Y., & Gao, W. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.022 · Cited by 94

Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance

Peng, J., Wang, G.-W., Han, Y., Qu, L., Wang, M., Arnsten, A. F. T., Cai, J., & Li, B. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03595-x · Cited by 6

NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline

McQuail, J. A., Beas, B. S., Kelly, K. B., Simpson, K. L., Frazier, C. J., Setlow, B., & Bizon, J. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2332-16.2016 · Cited by 80

Forebrain NR2B Overexpression Facilitating the Prefrontal Cortex Long-Term Potentiation and Enhancing Working Memory Function in Mice

Cui, Y., Jin, J., Zhang, X., Xu, H., Yang, L., Du, D., Zeng, Q., Tsien, J. Z., Yu, H., & Cao, X. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020312 · Cited by 133

Delayed-matching-to-position working memory in mice relies on NMDA-receptors in prefrontal pyramidal cells

Kilonzo, K., van der Veen, B., Teutsch, J., Schulz, S., Kapanaiah, S. K. T., Liss, B., & Kätzel, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-88200-z · Cited by 30