The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries
Open accessAbstract
DNA encoding facilitates the construction and screening of large chemical libraries. Here, we describe general strategies for the stepwise coupling of coding DNA fragments to nascent organic molecules throughout individual reaction steps as well as the first implementation of high-throughput sequencing for the identification and relative quantification of the library members. The methodology was exemplified in the construction of a DNA-encoded chemical library containing 4,000 compounds and in the discovery of binders to streptavidin, matrix metalloproteinase 3, and polyclonal human IgG.
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Cites
Encoded combinatorial chemistry.
Brenner, S., & Lerner, R. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5381 · Cited by 1,014
Cited by
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Heinis, C., Rutherford, T., Freund, S., & Winter, G. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.184 · Cited by 743
Design, synthesis and selection of DNA-encoded small-molecule libraries
Clark, M. A., Acharya, R. A., Arico-Muendel, C. C., Belyanskaya, S. L., Benjamin, D. R., Carlson, N. R., Centrella, P. A., Chiu, C. H., Creaser, S. P., Cuozzo, J. W., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.211 · Cited by 667
DNA-encoded chemistry: enabling the deeper sampling of chemical space
Goodnow, R. A., Dumelin, C. E., & Keefe, A. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.213 · Cited by 621
Self-citationNeri, D., & Lerner, R. A. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012550 · Cited by 364
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Metadata
- Authors
- Mannocci, L., Zhang, Y., Scheuermann, J., Leimbacher, M., De Bellis, G., Rizzi, E., Dumelin, C., Melkko, S., & Neri, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-11-18
- Volume
- 105
- Issue
- 46
- Pages
- 17670-17675
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038114311
- Cited by
- 223
- References
- 1
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Mannocci, L., Zhang, Y., Scheuermann, J., Leimbacher, M., De Bellis, G., Rizzi, E., Dumelin, C., Melkko, S., & Neri, D. (2008). High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0805130105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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