The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Genome-wide studies highlight indirect links between human replication origins and gene regulation
Open accessAbstract
To get insights into the regulation of replication initiation, we systematically mapped replication origins along 1% of the human genome in HeLa cells. We identified 283 origins, 10 times more than previously known. Origin density is strongly correlated with genomic landscapes, with clusters of closely spaced origins in GC-rich regions and no origins in large GC-poor regions. Origin sequences are evolutionarily conserved, and half of them map within or near CpG islands. Most of the origins overlap transcriptional regulatory elements, providing further evidence of a connection with gene regulation. Moreover, we identify c-JUN and c-FOS as important regulators of origin selection. Half of the identified replication initiation sites do not have an open chromatin configuration, showing the absence of a direct link with gene regulation. Replication timing analyses coupled with our origin mapping suggest that a relatively strict origin-timing program regulates the replication of the human genome.
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Cites
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Cited by
R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I., & Chédin, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.017 · Cited by 910
Sequencing newly replicated DNA reveals widespread plasticity in human replication timing
Hansen, R. S., Thomas, S., Sandstrom, R., Canfield, T. K., Thurman, R. E., Weaver, M., Dorschner, M. O., Gartler, S. M., & Stamatoyannopoulos, J. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912402107 · Cited by 552
DNA replication origin activation in space and time
Fragkos, M., Ganier, O., Coulombe, P., & Méchali, M. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4002 · Cited by 543
Eukaryotic Chromosome DNA Replication: Where, When, and How?
Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., & Oda, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.103205 · Cited by 498
Functional implications of genome topology
Cavalli, G., & Misteli, T. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2474 · Cited by 415
Metadata
- Authors
- Cadoret, J.-C., Meisch, F., Hassan-Zadeh, V., Luyten, I., Guillet, C., Duret, L., Quesneville, H., & Prioleau, M.-N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-10-14
- Volume
- 105
- Issue
- 41
- Pages
- 15837-15842
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101412414
- Cited by
- 313
- References
- 35
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Cadoret, J.-C., Meisch, F., Hassan-Zadeh, V., Luyten, I., Guillet, C., Duret, L., Quesneville, H., & Prioleau, M.-N. (2008). Genome-wide studies highlight indirect links between human replication origins and gene regulation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0805208105
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