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Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
Open accessAbstract
Parasitization by malaria-inducing Plasmodium falciparum leads to structural, biochemical, and mechanical modifications to the host red blood cells (RBCs). To study these modifications, we investigate two intrinsic indicators: the refractive index and membrane fluctuations in P. falciparum -invaded human RBCs ( Pf -RBCs). We report experimental connections between these intrinsic indicators and pathological states. By employing two noninvasive optical techniques, tomographic phase microscopy and diffraction phase microscopy, we extract three-dimensional maps of refractive index and nanoscale cell membrane fluctuations in isolated RBCs. Our systematic experiments cover all intraerythrocytic stages of parasite development under physiological and febrile temperatures. These findings offer potential, and sufficiently general, avenues for identifying, through cell membrane dynamics, pathological states that cause or accompany human diseases.
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Cited by
Diffraction phase microscopy: principles and applications in materials and life sciences
Bhaduri, B., Edwards, C., Pham, H., Zhou, R., Nguyen, T. H., Goddard, L. L., & Popescu, G. (2014) · Advances in Optics and Photonics · doi:10.1364/aop.6.000057 · Cited by 425
Self-citationCalculation of the radiative properties of photosynthetic microorganisms
Dauchet, J., Blanco, S., Cornet, J.-F., & Fournier, R. (2015) · Journal of Quantitative Spectroscopy and Radiative Transfer · doi:10.1016/j.jqsrt.2015.03.025 · Cited by 80
(2012) · doi:10.5772/31289 · Cited by 29
Pathophysiology of Severe Malaria Infection
Ohiagu, F. O., Chikezie, P. C., Ahaneku, C. C., Chikezie, C. M., & Law-Obi, F. C. (2021) · Asian Journal of Health Sciences · doi:10.15419/ajhs.v7i2.492 · Cited by 21
Metadata
- Authors
- Park, Y., Diez-Silva, M., Popescu, G., Lykotrafitis, G., Choi, W., Feld, M. S., & Suresh, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-09-16
- Volume
- 105
- Issue
- 37
- Pages
- 13730-13735
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2121047360
- Cited by
- 689
- References
- 0
- FWCI
- 20.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Park, Y., Diez-Silva, M., Popescu, G., Lykotrafitis, G., Choi, W., Feld, M. S., & Suresh, S. (2008). Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0806100105
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