Pathophysiology of Severe Malaria Infection

Ohiagu, Franklyn O.; Chikezie, Paul C.; Ahaneku, Clinton C.; Chikezie, Chinwendu M.; Law-Obi, Favour C.

doi:10.15419/ajhs.v7i2.492

Cited by 21Malaria Research and ControlHemoglobinopathies and Related DisordersErythrocyte Function and Pathophysiology

Pathophysiology of Severe Malaria Infection

Open access

Ohiagu, Franklyn O., Chikezie, Paul C., Ahaneku, Clinton C., Chikezie, Chinwendu M., Law-Obi, Favour C.·2021·Asian Journal of Health Sciences

DOI 10.15419/ajhs.v7i2.492

Open this paper in CoChat — free account Open PDF

Abstract

Background: Malaria infection is a multisystem pathology with various clinical complications in both adults and children. The clinical manifestation originates in humans following the invasion of erythrocytes by merozoites. Methods: The relevant information and data was collated from scientific databases such as Google Scholar, Science Direct, PubMed, Mendeley, Springer Link, and Medline using keywords such as ‘severe malaria infection’, ‘pathophysiology of severe malaria’, ‘complications of severe malaria’ and ‘erythrocyte impairment in severe malaria’. Results: Generally speaking, the pathophysiology of severe malaria infection encompasses a succession of stages involving the metabolic products of the malaria parasites inclusive of hemoglobin digestion, damaged erythrocyte membrane components, the actions of the pro- and anti-inflammatory cytokines, and the cytoadherence of the malaria parasites to the vascular endothelium as well as sequestration and rosetting. The major complications connected with severe malaria infection include acute respiratory distress syndrome, neurological disorders resulting from cerebral malaria, liver and kidney dysfunction, anaemia and thrombocytopenia, and fatal placental malaria. Conclusion: The effective management of severe malaria infection involves a proper diagnosis followed by the subjection of the patient to suitable antimalarial treatment with the necessary medications depending on the various clinical manifestations of the infection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.15419/ajhs.v7i2.492

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Severe maternal malaria can result in cerebral malaria, associated neurologic sequelae, malarial anemia, respiratory distress, hypoglycemia, and other pregnancy-related complications.
“Additionally, other studies have reported that severe maternal malaria can result in cerebral malaria, associated neurologic sequelae, malarial anemia, respiratory distress, hypoglycemia, and other pregnancy-related complications [131, 169, 171–173].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [173]
The “Placenta Pathology in Severe Malaria Infection” section (page unavailable) links malaria in pregnancy to anemia, cerebral malaria, hypoglycemia, and adverse pregnancy outcomes. The “Neurological Complications” and “Malaria-associated Acute Respiratory Distress Syndrome” sections (pages unavailable) discuss neurologic sequelae and respiratory distress in severe malaria generally, but do not specifically establish those complications in pregnant patients. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Infection also involves the action of pro-inflammatory and anti-inflammatory cytokines and the adherence of malaria parasites to the vascular endothelium, leading to sequestration and rosette formation.
“Infection also involves the action of pro-inflammatory and anti-inflammatory cytokines and the adherence of malaria parasites to the vascular endothelium, leading to sequestration and rosette formation [173].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [173]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

The economic and social burden of malaria
Sachs, J., & Malaney, P. (2002) · Nature · doi:10.1038/415680a · Cited by 2,248 · cited 2× · see citing works
“Malaria is one of the more widespread health issues worldwide 1 caused by the obligate intra-erythrocytic protozoa of the genus Plasmodium , of the following species, specifically P. falciparum , P. vivax , P. ovale , and P. malariae and in addition, recently P. knowlesi infecting humans 2 .”
Epidemiology and burden of malaria in pregnancy
Desai, M., ter Kuile, F. O., Nosten, F., McGready, R., Asamoa, K., Brabin, B., & Newman, R. D. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70021-x · Cited by 1,432 · see citing works
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,319 · see citing works
Malaria: progress, perils, and prospects for eradication
Greenwood, B. M., Fidock, D. A., Kyle, D. E., Kappe, S. H. I., Alonso, P. L., Collins, F. H., & Duffy, P. E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33996 · Cited by 709 · see citing works
Immunological processes in malaria pathogenesis
Schofield, L., & Grau, G. E. (2005) · Nature reviews. Immunology · doi:10.1038/nri1686 · Cited by 689 · see citing works
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum
Park, Y., Diez-Silva, M., Popescu, G., Lykotrafitis, G., Choi, W., Feld, M. S., & Suresh, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806100105 · Cited by 689 · see citing works
Clinical review: Severe malaria
Trampuz, A., Jereb, M., Muzlovič, I., & Prabhu, R. M. (2003) · Critical Care · doi:10.1186/cc2183 · Cited by 626 · see citing works
Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia
Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050128 · Cited by 609 · see citing works
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
Parroche, P., Lauw, F. N., Goutagny, N., Latz, E., Monks, B. G., Visintin, A., Halmen, K. A., Lamphier, M. S., Olivier, M., Bartholomeu, D. C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608745104 · Cited by 573 · see citing works
Severe malaria is associated with parasite binding to endothelial protein C receptor
Turner, L., Lavstsen, T., Berger, S. S., Wang, C. W., Petersen, J. E. V., Avril, M., Brazier, A. J., Freeth, J., Jespersen, J. S., Nielsen, M. A., et al. (2013) · Nature · doi:10.1038/nature12216 · Cited by 561 · see citing works
Dexamethasone Proves Deleterious in Cerebral Malaria
Warrell, D. A., Looareesuwan, S., Warrell, M. J., Kasemsarn, P., Intaraprasert, R., BUNNAG, D., & Harinasuta, T. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202113060601 · Cited by 485 · see citing works
Caspases: key mediators of apoptosis
Thornberry, N. A. (1998) · Chemistry & Biology · doi:10.1016/s1074-5521(98)90615-9 · Cited by 479 · see citing works
The Impact of Placental Malaria on Gestational Age and Birth Weight
Menendez, C., Ordi, J., Ismail, M. R., Ventura, P. J., Aponte, J. J., Kahigwa, E., Font, F., & Alonso, P. L. (2000) · The Journal of Infectious Diseases · doi:10.1086/315449 · Cited by 467 · see citing works
Antigenic Variation in Plasmodium falciparum
Scherf, A., Lopez-Rubio, J.-J., & Rivière, L. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093134 · Cited by 448 · see citing works
The pathophysiology of vivax malaria
Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.02.003 · Cited by 434 · see citing works
Neurological sequelae of cerebral malaria in children
Brewster, D., Kwiatkowski, D. P., & White, N. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)92498-7 · Cited by 407 · see citing works
A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction
van der Heyde, H. C., Nolan, J. P., Combes, V., Gramaglia, I., & Grau, G. E. (2006) · Trends in Parasitology · doi:10.1016/j.pt.2006.09.002 · Cited by 399 · see citing works
Antigenic Variation at the Infected Red Cell Surface in Malaria
Kyes, S., Horrocks, P., & Newbold, C. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.673 · Cited by 393 · see citing works
Plasmodium vivaxMalaria
Kochar, D. K., Saxena, V., Singh, N., Kochar, S. K., Kumar, S. V., & Das, A. (2005) · Emerging infectious diseases · doi:10.3201/eid1101.040519 · Cited by 382 · see citing works
Adhesion ofPlasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications
Rowe, J. A., Claessens, A., Corrigan, R. A., & Arman, M. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001082 · Cited by 373 · see citing works
Clinical features and pathogenesis of severe malaria
Mackintosh, C. L., Beeson, J. G., & Marsh, K. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.09.006 · Cited by 366 · see citing works
Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting
Rowe, J. A., Handel, I. G., Thera, M. A., Deans, A.-M., Lyke, K. E., Kone, A. K., Diallo, D. A., Raza, A., Kai, O. K., Marsh, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705390104 · Cited by 345 · see citing works
MALARIAL RETINOPATHY: A NEWLY ESTABLISHED DIAGNOSTIC SIGN IN SEVERE MALARIA
Beare, N. A. V., TAYLOR, T. E., Harding, S. P., et al. (2006) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2006.75.790 · Cited by 344 · see citing works
Clinical and Laboratory Features of Human Plasmodium knowlesi Infection
Daneshvar, C., Davis, T. M. E., Cox‐Singh, J., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/605439 · Cited by 340 · see citing works
Placental pathology in malaria: A histological, immunohistochemical, and quantitative study
Ismail, M. R., Ordi, J., Menendez, C., Ventura, P. J., Aponte, J. J., Kahigwa, E., Hirt, R., Cardesa, A., & Alonso, P. L. (2000) · Human Pathology · doi:10.1016/s0046-8177(00)80203-8 · Cited by 328 · see citing works
The ABO blood group system and Plasmodium falciparum malaria
Cserti, C. M., & Dzik, W. H. (2007) · Blood · doi:10.1182/blood-2007-03-077602 · Cited by 320 · see citing works
Human malarial disease: a consequence of inflammatory cytokine release
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-85 · Cited by 318 · see citing works
Severe Malarial Anemia: Innate Immunity and Pathogenesis
Perkins, D. J., Were, T., Davenport, G. C., Kempaiah, P. M., Hittner, J. B., & Ong’echa, J. M. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.1427 · Cited by 316 · see citing works
Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem
Rogerson, S. J., Desai, M., Mayor, A., Sicuri, E., Taylor, S. M., & van Eijk, A. M. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30066-5 · Cited by 306 · see citing works
The Relationship between Age and the Manifestations of and Mortality Associated with Severe Malaria
Dondorp, A. M., Lee, S. J., Faiz, M. A., Mishra, S. K., Price, R. N., Tjitra, E., Than, M., Htut, Y., Mohanty, S., Yunus, E. B., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/589287 · Cited by 279 · see citing works
PLACENTAL MONOCYTE INFILTRATES IN RESPONSE TO PLASMODIUM FALCIPARUM MALARIA INFECTION AND THEIR ASSOCIATION WITH ADVERSE PREGNANCY OUTCOMES
ROGERSON, S. J., POLLINA, E., GETACHEW, A., TADESSE, E., LEMA, V. M., & MOLYNEUX, M. E. (2003) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2003.68.1.0680115 · Cited by 275 · see citing works
Impairment of a pregnant woman’s acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1
Steketee, R. W., Chilima, B., Chitsulo, L., Bloland, P. B., Breman, J. G., Mermin, J., & Wirima, J. J. (1996) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1996.55.42 · Cited by 258 · see citing works
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya
Maina, R. N., Walsh, D. S., Gaddy, C., Hongo, G., Waitumbi, J. N., Otieno, L., Jones, D., & Ogutu, B. R. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-s3-s4 · Cited by 258 · see citing works
A human complement receptor 1 polymorphism that reduces <i>Plasmodium falciparum</i> rosetting confers protection against severe malaria
Cockburn, I. A., Mackinnon, M. J., O'Donnell, A., Allen, S. J., Moulds, J. M., Baisor, M., Bockarie, M., Reeder, J. C., & Rowe, J. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305306101 · Cited by 255 · see citing works
Molecular Aspects of Severe Malaria
Chen, Q., Schlichtherle, M., & Wahlgren, M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.3.439 · Cited by 242 · see citing works
Malaria, erythrocytic infection, and anemia
Haldar, K., & Mohandas, N. (2009) · Hematology · doi:10.1182/asheducation-2009.1.87 · Cited by 240 · see citing works
Glycosylphosphatidylinositol Anchors ofPlasmodium falciparum
Naik, R. S., Branch, O. H., Woods, A. S., Vijay–Kumar, M., Perkins, D. J., Nahlen, B. L., Lal, A. A., Cotter, R. J., Costello, C. E., Ockenhouse, C. F., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1563 · Cited by 240 · see citing works
Nuclear factor-κB: a friend or a foe in cancer?
Shishodia, S., & Aggarwal, B. B. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.04.026 · Cited by 228 · see citing works
Apoptosis in liver during malaria: role of oxidative stress and implication of mitochondrial pathway
Guha, M., Kumar, S., Choubey, V., Maity, P., & Bandyopadhyay, U. (2006) · The FASEB Journal · doi:10.1096/fj.05-5338fje · Cited by 216 · see citing works
Malarial Acute Renal Failure
Barsoum, R. S. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11112147 · Cited by 212 · see citing works
Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report
Cox‐Singh, J., Hiu, J., Lucas, S. B., Divis, P. C. S., Zulkarnaen, M., Chandran, P. A., Wong, K. T., Adem, P. V., Zaki, S. R., Singh, B. B., et al. (2010) · Malaria Journal · doi:10.1186/1475-2875-9-10 · Cited by 209 · see citing works
Thrombocytopenia in malaria: who cares?
Lacerda, M., Mourão, M. P. G., Coelho, H. C. C., & Santos, J. B. (2011) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762011000900007 · Cited by 209 · see citing works
Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology
Dondorp, A. M., Pongponratn, E., & White, N. J. (2003) · Acta Tropica · doi:10.1016/j.actatropica.2003.10.004 · Cited by 209 · see citing works
Lung Injury in Vivax Malaria: Pathophysiological Evidence for Pulmonary Vascular Sequestration and Posttreatment Alveolar‐Capillary Inflammation
Anstey, N. M., Handojo, T., PAIN, M. C. F., Kenangalem, E., Tjitra, E., Price, R. N., & Maguire, G. P. (2007) · The Journal of Infectious Diseases · doi:10.1086/510756 · Cited by 202 · see citing works
Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial
von Seidlein, L., Olaosebikan, R., Hendriksen, I. C. E., Lee, S. J., Adedoyin, O., Agbenyega, T., Nguah, S. B., Bojang, K., Deen, J. L., Evans, J., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis034 · Cited by 191 · see citing works
Malaria in Pregnancy: Linking Immunity and Pathogenesis to Prevention
Rogerson, S. J., Mwapasa, V., & Meshnick, S. R. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.77.6.suppl.14 · Cited by 183 · see citing works
Malaria and the red blood cell membrane.
Cooke, B. M., Mohandas, N., & Coppel, R. (2004) · Seminars in hematology (Print) · doi:10.1053/j.seminhematol.2004.01.004 · Cited by 169 · see citing works
PfEMP1: An antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum
Pasternak, N. D., & Dzikowski, R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.012 · Cited by 167 · see citing works
Differential Induction of TGF-β Regulates Proinflammatory Cytokine Production and Determines the Outcome of Lethal and Nonlethal Plasmodium yoelii Infections
Omer, F. M., de Souza, J. B., & Riley, E. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5430 · Cited by 154 · see citing works
Heparan sulfate on endothelial cells mediates the binding ofPlasmodium falciparum–infected erythrocytes via the DBL1α domain of PfEMP1
Vogt, A. M., Barragán, A., Chen, Q., Kironde, F., Spillmann, D., & Wahlgren, M. (2003) · Blood · doi:10.1182/blood-2002-07-2016 · Cited by 150 · see citing works
Pulmonary Manifestations of Uncomplicated Falciparum and Vivax Malaria: Cough, Small Airways Obstruction, Impaired Gas Transfer, and Increased Pulmonary Phagocytic Activity
Anstey, N. M., Jacups, S. P., Cain, T. M., Pearson, T., Ziesing, P., Fisher, D. A., Currie, B. J., Marks, P. J., & Maguire, G. P. (2002) · The Journal of Infectious Diseases · doi:10.1086/339885 · Cited by 149 · see citing works
Acute lung injury and acute respiratory distress syndrome in malaria.
Mohan, A., Sharma, S. K., & Bollineni, S. (2008) · PubMed · Cited by 142 · see citing works
Severe malaria: what’s new on the pathogenesis front?
Wassmer, S. C., & Grau, G. E. (2016) · International Journal for Parasitology · doi:10.1016/j.ijpara.2016.08.002 · Cited by 142 · see citing works
Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?
Franke-Fayard, B. M. D., Fonager, J., Braks, A. A. M., Khan, S. M., & Janse, C. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001032 · Cited by 139 · see citing works
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia
McDevitt, M. A., Xie, J., Ganapathy‐Kanniappan, S., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052398 · Cited by 137 · see citing works
Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium
Faille, D., Combes, V., Mitchell, A. J., Fontaine, A., Juhan-Vague, I., Alessi, M., Chimini, G., Fusaı̈, T., & Grau, G. E. (2009) · The FASEB Journal · doi:10.1096/fj.09-135822 · Cited by 125 · see citing works
VEGF Promotes Malaria-Associated Acute Lung Injury in Mice
Epiphânio, S., Campos, M. G., Pamplona, A., Carapau, D., Pena, A. C., Ataíde, R., Monteiro, C. A. A., Félix, N., Costa-Silva, A., Marinho, C. R. F., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000916 · Cited by 123 · see citing works
Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice
Sercundes, M. K., Ortolan, L. D. S., Debone, D., Pereira, P. V. S., Gomes, E., Aitken, E. H., Condino‐Neto, A., Russo, M., Lima, M. R. D., Álvarez, J. M., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006054 · Cited by 123 · see citing works
High Deformability ofPlasmodium vivax–Infected Red Blood Cells under Microfluidic Conditions
Handayani, S., Chiu, D. T.-Y., Tjitra, E., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/596048 · Cited by 121 · see citing works
PATHOGENESIS OF MALARIA IN TISSUES AND BLOOD
Autino, B., Corbett, Y., Castelli, F., & Taramelli, D. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.061 · Cited by 119 · see citing works
Pathogenesis of malaria-associated acute respiratory distress syndrome
den Steen, P. E. V., Deroost, K., Deckers, J., Herck, E. V., Struyf, S., & Opdenakker, G. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.04.006 · Cited by 116 · see citing works
Retention of erythrocytes in the spleen: a double-edged process in human malaria
Buffet, P. A., Safeukui, I., Milon, G., Mercereau‐Puijalon, O., & David, P. H. (2009) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32832a1d4b · Cited by 115 · see citing works
High Levels of Plasmodium falciparum Rosetting in All Clinical Forms of Severe Malaria in African Children
Doumbo, O. K., Thera, M. A., Kone, A. K., Raza, A., Tempest, L. J., Lyke, K. E., Plowe, C. V., & Rowe, J. A. (2009) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.09-0406 · Cited by 114 · see citing works
Placental Malaria: A New Insight into the Pathophysiology
Sharma, L., & Shukla, G. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00117 · Cited by 111 · see citing works
Hepatocyte dysfunction and hepatic encephalopathy in Plasmodium falciparum malaria
Kochar, D. K., Agarwal, P., Kochar, S. K., et al. (2003) · QJM · doi:10.1093/qjmed/hcg091 · Cited by 109 · see citing works
Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria
de Mast, Q., Syafruddin, D., Keijmel, S. P., Riekerink, T. O., Deky, O., Asih, P. B. S., Swinkels, D. W., & van der Ven, A. J. A. M. (2010) · Haematologica · doi:10.3324/haematol.2009.019331 · Cited by 109 · see citing works
Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria
Plewes, K., Turner, G. D. H., & Dondorp, A. M. (2017) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000419 · Cited by 108 · see citing works
Plasmodium falciparum: Chondroitin sulfate A is the major receptor for adhesion of parasitized erythrocytes in the placenta
Fried, M., Domingo, G. J., Gowda, C. D., Mutabingwa, T. K., & Duffy, P. E. (2006) · Experimental Parasitology · doi:10.1016/j.exppara.2005.12.003 · Cited by 107 · see citing works
Hemozoin Induces Lung Inflammation and Correlates with Malaria-Associated Acute Respiratory Distress Syndrome
Deroost, K., Tyberghein, A., Lays, N., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0450oc · Cited by 104 · see citing works
Febrile temperatures induce cytoadherence of ring-stage Plasmodium falciparum -infected erythrocytes
Udomsangpetch, R., Pipitaporn, B., Silamut, K., Pinches, R. A., Kyes, S., Looareesuwan, S., Newbold, C., & White, N. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398999 · Cited by 103 · see citing works
Imported Malaria
Svenson, J. E. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430080109013 · Cited by 103 · see citing works
Hemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors
Lamikanra, A., Theron, M., Kooij, T. W. A., & Roberts, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008446 · Cited by 102 · see citing works
The role of ICAM-1 in Plasmodium falciparum cytoadherence
Chakravorty, S. J., & Craig, A. G. (2004) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2004.09.002 · Cited by 101 · see citing works
Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal
Skorokhod, O. A., Caione, L., Marrocco, T., Migliardi, G., Barrera, V., Arese, P., Piacibello, W., & Schwarzer, E. (2010) · Blood · doi:10.1182/blood-2010-03-272781 · Cited by 100 · see citing works
Cerebral Malaria Pathogenesis: Revisiting Parasite and Host Contributions
Grau, G. E., & Craig, A. G. (2012) · Future Microbiology · doi:10.2217/fmb.11.155 · Cited by 100 · see citing works
Pathogenesis of anemia in malaria: a concise review
Ghosh, K., & Ghosh, K. K. (2007) · Parasitology Research · doi:10.1007/s00436-007-0742-1 · Cited by 96 · see citing works
Malarial infection develops mitochondrial pathology and mitochondrial oxidative stress to promote hepatocyte apoptosis.
Dey, S., Guha, M., Alam, A., Goyal, M., Bindu, S., Pal, C., Maity, P., Mitra, K., & Bandyopadhyay, U. (2009) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2008.10.032 · Cited by 92 · see citing works
Thrombocytopenia inPlasmodium falciparum,Plasmodium vivaxand mixed infection malaria: A study from Bikaner (Northwestern India)
Kochar, D. K., Das, A., Kochar, A., Middha, S., Acharya, J., Tanwar, G. S., Gupta, A., Pakalapati, D., Garg, S., Saxena, V., et al. (2010) · Platelets · doi:10.3109/09537104.2010.505308 · Cited by 91 · see citing works
ADAMTS13 Deficiency with Elevated Levels of Ultra-Large and Active von Willebrand Factor in P. falciparum and P. vivax Malaria
de Mast, Q., de Groot, E. L., Asih, P. B. S., et al. (2009) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.492 · Cited by 86 · see citing works
Malária grave por Plasmodium falciparum
Gomes, A. P., Vitorino, R. R., Costa, A. D. P., et al. (2011) · Revista Brasileira de Terapia Intensiva · doi:10.1590/s0103-507x2011000300015 · Cited by 83 · see citing works
Role of Monocyte-Acquired Hemozoin in Suppression of Macrophage Migration Inhibitory Factor in Children with Severe Malarial Anemia
Awandare, G. A., Ouma, Y., Ouma, C., et al. (2006) · Infection and Immunity · doi:10.1128/iai.01327-06 · Cited by 81 · see citing works
Relationships between infection with Plasmodium falciparum during pregnancy, measures of placental malaria, and adverse birth outcomes
Kapisi, J., Kakuru, A., Jagannathan, P., Muhindo, M. K., Natureeba, P., Awori, P., Nakalembe, M., Ssekitoleko, R., Olwoch, P., Ategeka, J., et al. (2017) · Malaria Journal · doi:10.1186/s12936-017-2040-4 · Cited by 78 · see citing works
Epidemiology, pathophysiology, management and outcome of renal dysfunction associated with plasmodia infection
Elsheikha, H., & Sheashaa, H. (2007) · Parasitology Research · doi:10.1007/s00436-007-0650-4 · Cited by 77 · see citing works
Micronutrient malnutrition and the pathogenesis of malarial anemia
Nussenblatt, V. R., & Semba, R. D. (2002) · Acta Tropica · doi:10.1016/s0001-706x(02)00049-9 · Cited by 72 · see citing works
Dehydration and malaria augment the risk of developing chronic kidney disease in Sri Lanka
Siriwardhana, E. A. R. I. E., Perera, P. A. J., Sivakanesan, R., et al. (2015) · Indian Journal of Nephrology · doi:10.4103/0971-4065.140712 · Cited by 71 · see citing works
Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study
Elphinstone, R. E., Weckman, A. M., McDonald, C. R., Tran, V., Zhong, K., Madanitsa, M., Kalilani‐Phiri, L., Khairallah, C., Taylor, S. M., Meshnick, S. R., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002914 · Cited by 68 · see citing works
Hot, sweet and sticky: the glycobiology of Plasmodium falciparum
von Itzstein, M., Plebanski, M., Cooke, B. M., & Coppel, R. L. (2008) · Trends in Parasitology · doi:10.1016/j.pt.2008.02.007 · Cited by 65 · see citing works
Host response to cytoadherence inPlasmodium falciparum
Chakravorty, S. J., Hughes, K. R., & Craig, A. G. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360221 · Cited by 65 · see citing works
Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria
Punsawad, C., Maneerat, Y., Chaisri, U., et al. (2013) · Malaria Journal · doi:10.1186/1475-2875-12-260 · Cited by 64 · see citing works
Hepatic changes in fatal malaria: an emerging problem
Rupani, A., & Amarapurkar, A. D. (2009) · Annals of Tropical Medicine and Parasitology · doi:10.1179/136485909x385054 · Cited by 62 · see citing works
Effects of Malaria Heme Products on Red Blood Cell Deformability
Nuchsongsin, F., Chotivanich, K., Charunwatthana, P., Fausta, O.-S., Taramelli, D., Day, N., White, N. J., & Dondorp, A. M. (2007) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.617 · Cited by 62 · see citing works
Inflammasome activation and IL-1 signaling during placental malaria induce poor pregnancy outcomes
Reis, A. S., Barboza, R., Murillo, O. J., Barateiro, A., Peixoto, E. P. M., Lima, F. A., Gomes, V. M., Dombrowski, J. G., Leal, V. N. C., Araújo, F. R., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax6346 · Cited by 62 · see citing works
Cerebral malaria in Indian adults: a prospective study of 441 patients from Bikaner, north-west India.
Kochar, D. K., Shubhakaran, Kumawat, B. L., Kochar, S. K., Halwai, M. A., Makkar, R. K., Joshi, A., & Thanvi, I. (2002) · PubMed · Cited by 58 · see citing works
A quantitative ultrastructural study of the liver and the spleen in fatal falciparum malaria.
Prommano, O., Chaisri, U., Turner, G. D. H., Wilairatana, P., Ferguson, D. J. P., Viriyavejakul, P., White, N. J., & Pongponratn, E. (2005) · PubMed · Cited by 56 · see citing works
Murine Malaria Infection Induces Fetal Loss Associated with Accumulation ofPlasmodium chabaudiAS-Infected Erythrocytes in the Placenta
Poovassery, J. S., & Moore, J. M. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2839-2848.2006 · Cited by 55 · see citing works
A perspective of the epidemiology of malaria and anaemia and their impact on maternal and perinatal outcomes in Sudan
Adam, I., Elhassan, E. M., Haggaz, A. E. D., Ali, A. A. A., & Adam, G. K. (2010) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.1282 · Cited by 54 · see citing works
Plasmodium vivax Malaria–associated Acute Kidney Injury, India, 2010–2011
Kute, V. B., Trivedi, H. L., Vanikar, A. V., Shah, P. R., Gumber, M. R., Patel, H. V., Goswami, J. G., & Kanodia, K. V. (2012) · Emerging infectious diseases · doi:10.3201/eid1805.111442 · Cited by 54 · see citing works
Malaria-Induced Murine Pregnancy Failure: Distinct Roles for IFN-γ and TNF
Poovassery, J. S., Sarr, D., Smith, G., Nagy, T., & Moore, J. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901669 · Cited by 53 · see citing works
Risk Factors and Outcomes Stratified by Severity of Acute Kidney Injury in Malaria
Saravu, K., Kumar, R., & Parikh, C. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090419 · Cited by 53 · see citing works
Bronchiolitis Obliterans Organizing Pneumonia Caused by Plasmodium vivax Malaria
Yale, S. H., Adlakha, A., Sebo, T. J., et al. (1993) · CHEST Journal · doi:10.1378/chest.104.4.1294 · Cited by 53 · see citing works
Liver pathology in Malawian children with fatal encephalopathy
Whitten, R. O., Milner, D. A., Yeh, M. M., et al. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.11.019 · Cited by 52 · see citing works
Malaria in Early Pregnancy and the Development of the Placental Vasculature
Møller, S. L., Nyengaard, J. R., Larsen, L. G., Nielsen, K. B., Bygbjerg, I. C., Msemo, O. A., Lusingu, J., Minja, D. T. R., Theander, T. G., & Schmiegelow, C. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy735 · Cited by 52 · see citing works
Lopinavir/Ritonavir-Based Antiretroviral Treatment (ART) Versus Efavirenz-Based ART for the Prevention of Malaria Among HIV-Infected Pregnant Women
Natureeba, P., Ades, V., Luwedde, F., Mwesigwa, J., Plenty, A., Okong, P., Charlebois, E. D., Clark, T. D., Nzarubara, B., Havlir, D. V., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu346 · Cited by 50 · see citing works
Thrombocytopaenia in pregnant women with malaria on the Thai-Burmese border
Tan, S. O., McGready, R. M., Zwang, J., Pimanpanarak, M., Sriprawat, K., Thwai, K. L., Moo, Y., Ashley, E. A., Edwards, B., Singhasivanon, P., et al. (2008) · Malaria Journal · doi:10.1186/1475-2875-7-209 · Cited by 44 · see citing works
Placental changes associated with fetal outcome in the Plasmodium coatneyi/rhesus monkey model of malaria in pregnancy.
Davison, B. B., Cogswell, F. B., Baskin, G. B., Falkenstein, K. P., Henson, E. W., & Krogstad, D. J. (2000) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2000.63.158 · Cited by 44 · see citing works
Asymptomatic malaria infection among pregnant women attending antenatal care in malaria endemic areas of North-Shoa, Ethiopia: a cross-sectional study
Feleke, D. G., Adamu, A., Gebreweld, A., Tesfaye, M., Demsiss, W., & Fenta, G. M. (2020) · Malaria Journal · doi:10.1186/s12936-020-3152-9 · Cited by 44 · see citing works
Rethinking cerebral malaria pathology
Milner, D. A. (2010) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32833c3dbe · Cited by 43 · see citing works
Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin
Maknitikul, S., Luplertlop, N., Grau, G. E., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181674 · Cited by 43 · see citing works
Iron delocalisation in the pathogenesis of malarial anaemia
Nweneka, C. V., Doherty, C. P., Cox, S. E., & Prentice, A. M. (2009) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2009.08.007 · Cited by 41 · see citing works
Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS
Pereira, M. H. N., Ortolan, L. D. S., Sercundes, M. K., Debone, D., Murillo, O. J., Lima, F. A., Marinho, C. R. F., & Epiphânio, S. (2016) · Mediators of Inflammation · doi:10.1155/2016/4158698 · Cited by 39 · see citing works
Histopathological lesions and exposure to Plasmodium falciparum infections in the placenta increases the risk of preeclampsia among pregnant women
Obiri, D., Erskine, I. J., Oduro, D., Kusi, K. A., Amponsah, J. A., Gyan, B. A., Adu‐Bonsaffoh, K., & Ofori, M. F. (2020) · Scientific Reports · doi:10.1038/s41598-020-64736-4 · Cited by 39 · see citing works
Transfer of 4‐hydroxynonenal from parasitized to non‐parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia
Uyoga, S. M., Skorokhod, O. A., Opiyo, M., et al. (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2011.09015.x · Cited by 38 · see citing works
Plasmodium falciparum Plasmodiumhelical interspersed subtelomeric proteins contribute to cytoadherence and anchorP. falciparumerythrocyte membrane protein 1 to the host cell cytoskeleton
Oberli, A., Zurbrügg, L., Rusch, S., et al. (2016) · Cellular Microbiology · doi:10.1111/cmi.12583 · Cited by 38 · see citing works
Syncytiotrophoblast Functions and Fetal Growth Restriction during Placental Malaria: Updates and Implication for Future Interventions
Kidima, W. B. (2015) · BioMed Research International · doi:10.1155/2015/451735 · Cited by 37 · see citing works
Placental but Not Peripheral Plasmodium falciparum Infection During Pregnancy Is Associated With Increased Risk of Malaria in Infancy
Boudová, S., Divala, T. H., Mungwira, R. G., Mawindo, P., Tomoka, T., & Laufer, M. K. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix372 · Cited by 35 · see citing works
A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury
Ampawong, S., Chaisri, U., Viriyavejakul, P., Prapansilp, P., Grau, G. E., Turner, G. D. H., & Pongponratn, E. (2015) · Malaria Journal · doi:10.1186/s12936-015-0922-x · Cited by 33 · see citing works
Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome
Aitken, E. H., Negri, E. M., Barboza, R., et al. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-230 · Cited by 32 · see citing works
Neutrophil Extracellular Traps Open the Pandora’s Box in Severe Malaria
Boeltz, S., Munoz, L. E., Fuchs, T. A., & i, M. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00874 · Cited by 32 · see citing works
Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice
Ortolan, L. D. S., Sercundes, M. K., Barboza, R., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/872464 · Cited by 28 · see citing works
Malarial fever: Hemozoin is involved but Toll-free
Schumann, R. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610874104 · Cited by 27 · see citing works
Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria
Clark, R. L. (2019) · Birth Defects Research · doi:10.1002/bdr2.1496 · Cited by 27 · see citing works
Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria
Horata, N., Kalambaheti, T., Craig, A., & Khusmith, S. (2009) · Malaria Journal · doi:10.1186/1475-2875-8-184 · Cited by 26 · see citing works
Complement Activation in Placental Malaria
McDonald, C. R., Tran, V., & Kain, K. C. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01460 · Cited by 25 · see citing works
Pre-clinical and clinical development of the first placental malaria vaccine
Pehrson, C., Salanti, A., Theander, T. G., & Nielsen, M. A. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1322512 · Cited by 25 · see citing works
Pathogenic CD8+ T Cells Cause Increased Levels of VEGF-A in Experimental Malaria-Associated Acute Respiratory Distress Syndrome, but Therapeutic VEGFR Inhibition Is Not Effective
Pham, T., Verheijen, M., Vandermosten, L., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00416 · Cited by 25 · see citing works
Changes in platelet count in uncomplicated and severe falciparum malaria.
Leowattana, W., Tangpukdee, N., Thar, S. K., et al. (2010) · PubMed · Cited by 24 · see citing works
Urinary bile casts in bile cast nephropathy secondary to severe falciparum malaria
Mohapatra, M. K., Behera, A. K., Karua, P. C., et al. (2016) · Clinical Kidney Journal · doi:10.1093/ckj/sfw042 · Cited by 24 · see citing works
Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity
Odorizzi, P. M., & Feeney, M. E. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.08.005 · Cited by 24 · see citing works
Impaired placental autophagy in placental malaria
Dimasuay, K. G., Gong, L., Rosario, F. J., McBryde, E. S., Spelman, T. D., Glazier, J. D., Rogerson, S. J., Beeson, J. G., Jansson, T., Devenish, R. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187291 · Cited by 24 · see citing works
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS)
de Azevedo-Quintanilha, I. G., Vieira‐de‐Abreu, A., Ferreira, A. C., Nascimento, D. O., Siqueira, A. M., Campbell, R. A., Ferreira, T. P. T., Gutierrez, T. M., Ribeiro, G., Silva, P., et al. (2016) · Malaria Journal · doi:10.1186/s12936-016-1447-7 · Cited by 23 · see citing works
Outcome and Complications of Malaria in Pregnancy
Saba, N., Sultana, A., & Mahsud, I. (2004) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 22 · see citing works
Plasmodium Vivax causing acute kidney injury: A foe less addressed
Naqvi, R. (2015) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.316.8859 · Cited by 20 · see citing works
Plasmodium vivax: paroxysm-associated lipids mediate leukocyte aggregation
Karunaweera, N. D., Wanasekara, D., Chandrasekharan, V., et al. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-62 · Cited by 18 · see citing works
Plasmodium falciparum infection dysregulates placental autophagy
Lima, F. A., Barateiro, A., Dombrowski, J. G., de Souza, R. M., Costa, D. D. S., Murillo, O. J., Epiphânio, S., Gonçalves, L. A., & Marinho, C. R. F. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226117 · Cited by 17 · see citing works
Malaria in Pregnancy: What the Obstetric Provider in Nonendemic Areas Needs to Know
Zakama, A. K., & Gaw, S. L. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000704 · Cited by 16 · see citing works
Abundance of megalin and Dab2 is reduced in syncytiotrophoblast during placental malaria, which may contribute to low birth weight
Lybbert, J., Gullingsrud, J., Chesnokov, O., Turyakira, E., Dhorda, M., Guerin, P. J., Piola, P., Muehlenbachs, A., & Oleinikov, A. V. (2016) · Scientific Reports · doi:10.1038/srep24508 · Cited by 15 · see citing works
Placental malaria and modulation of immune and hormonal responses in Cameroonian women
Megnekou, R., Tenou, S., Bigoga, J. D., Djontu, J. C., Medou, F. M., & Lissom, A. (2015) · Acta Tropica · doi:10.1016/j.actatropica.2015.04.001 · Cited by 14 · see citing works
Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment
Lawford, H. L. S., Lee, A. C., Kumar, S., Liley, H. G., & Bora, S. (2019) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2019.04.019 · Cited by 14 · see citing works
Factors associated with acute renal failure in adults with severe falciparum malaria.
Kk, W., Thanachartwet, V., Wattanagoon, Y., et al. (2012) · PubMed · Cited by 12 · see citing works
Congenital Malaria in Newborns Presented at Tororo General Hospital in Uganda: A Cross-Sectional Study
Hangi, M., Achan, J., Saruti, A., Quinlan, J., & Idro, R. (2019) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0341 · Cited by 12 · see citing works
Placental mitochondrial DNA copy number is associated with reduced birth weight in women with placental malaria
Oktavianthi, S., Fauzi, M. I., Trianty, L., et al. (2019) · Placenta · doi:10.1016/j.placenta.2019.03.005 · Cited by 9 · see citing works
Severe Retinal Whitening in an Adult with Cerebral Malaria
Maude, R. J., Hassan, M. U., & Beare, N. A. V. (2009) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.881 · Cited by 8 · see citing works
Acute Hepatitis in Malaria.
Shoukier, H., Dham, S. K., Bergasa, N. V., et al. (2006) · PubMed · Cited by 5 · see citing works
Acute Respiratory Distress Syndrome
Mols, G., & Haberthür, C. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828fd91e · Cited by 4 · see citing works
How Not to Miss a Case of Malaria in Emergency Department in Malaria Non-Endemic Areas? Practical Approach & Experiences in Hong Kong
Li, I. W. S., & Cheung, L. C. P. (2016) · Open Journal of Emergency Medicine · doi:10.4236/ojem.2016.44012 · Cited by 3 · see citing works
Lung Involvement in Malaria
Kingston, H. W. F., Turner, G. D. H., & Day, N. (2015) · Springer eBooks · doi:10.1007/978-1-4614-8326-7_124 · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Current update on malaria in pregnancy: a systematic review
Minwuyelet, A., Yewhalaw, D., Siferih, M., & Atenafu, G. (2025) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-025-00248-1 · Cited by 49 · see citing works

Factors Contributing to the Development of Cerebral Malaria
Tharavanij, S., Warrell, M. J., Tantivanich, S., et al. (1984) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1984.33.1 · Cited by 26 · see citing works
Intraleucocytic malaria pigment and clinical severity of malaria in children
Amodu, O. K., Adeyemo, A., Olumese, P. E., et al. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)90952-x · Cited by 110 · see citing works
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
Kwiatkowski, D. P., Sambou, I., Twumasi, P., Greenwood, B. M., Hill, A. V. S., Manogue, K. R., Cerami, A., Castracane, J. M., & Brewster, D. (1990) · The Lancet · doi:10.1016/0140-6736(90)92827-5 · Cited by 870 · see citing works
Recrudescent plasmodium falciparum malaria after head trauma: a case report with novel clinical perspectivePreprint
Liu, S., Wang, X., Ni, Q., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3269652/v1
Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models
Ndunge, O. B. A., Kilian, N., & Salman, M. M. (2022) · Advanced Science · doi:10.1002/advs.202202944 · Cited by 32 · see citing works

Authors: Ohiagu, F. O., Chikezie, P. C., Ahaneku, C. C., Chikezie, C. M., & Law-Obi, F. C.
Affiliations: Imo State University (NG)
Federal University of Technology Owerri (NG)
Corresponding author: Ohiagu, Franklyn O.
Chikezie, Paul C.
Ahaneku, Clinton C.
Chikezie, Chinwendu M.
Law-Obi, Favour C.
ORCID: Ohiagu, Franklyn O.
Chikezie, Paul C.
Chikezie, Chinwendu M.
Venue: Asian Journal of Health Sciences
Publisher: Biomedpress
Published: 2021-10-01
Volume: 7
Issue: 2
Pages: 22-22
ISSN: 2347-5218 (ISSN-L)
DOI: 10.15419/ajhs.v7i2.492
OpenAlex: W3203891550
Cited by: 21
References: 146
Citations by year: 2026: 9 · 2025: 7 · 2024: 2 · 2023: 3
FWCI: 1.08
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Asian Journal of Health Sciences (publishedVersion, cc-by)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords: severe malaria, pathophysiology, merozoite invasion, hemoglobin digestion, cytokines, cytoadherence, rosette formation, cerebral malaria, acute respiratory distress syndrome, placental malaria, anemia, thrombocytopenia, liver and kidney dysfunction, malaria treatment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathophysiology of Severe Malaria Infection

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks