Cited by 572FOXO transcription factor regulationGenetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.

Association of FOXO3A variation with human longevity confirmed in German centenarians

Open access

Flachsbart, Friederike, Caliebe, Amke, Kleindorp, Rabea, Blanché, Hélène, von Eller-Eberstein, Huberta, Nikolaus, Susanna, Schreiber, Stefan, Nebel, Almut·2009·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0809594106PMC PMC2650329

Open this paper in CoChat — free account

Abstract

The human forkhead box O3A gene ( FOXO3A ) encodes an evolutionarily conserved key regulator of the insulin–IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms. A recent study described 3 SNPs in the FOXO3A gene that were statistically significantly associated with longevity in a discovery sample of long-lived men of Japanese ancestry [Willcox et al. (2008) Proc Natl Acad Sci USA 105:13987–13992]. However, this finding required replication in an independent population. Here, we have investigated 16 known FOXO3A SNPs in an extensive collection of 1,762 German centenarians/nonagenarians and younger controls and provide evidence that polymorphisms in this gene were indeed associated with the ability to attain exceptional old age. The FOXO3A association was considerably stronger in centenarians than in nonagenarians, highlighting the importance of centenarians for genetic longevity research. Our study extended the initial finding observed in Japanese men to women and indicates that both genders were likely to be equally affected by variation in FOXO3A . Replication in a French centenarian sample generated a trend that supported the previous results. Our findings confirmed the initial discovery in the Japanese sample and indicate FOXO3A as a susceptibility gene for prolonged survival in humans.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.0809594106

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337
Power and Sample Size Calculations for Studies Involving Linear Regression
Dupont, W. D., & Plummer, W. D. (1998) · Controlled Clinical Trials · doi:10.1016/s0197-2456(98)00037-3 · Cited by 1,024
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
Herskind, A. M., McGue, M., Holm, N. V., Sørensen, T. I. A., Harvald, B., & Vaupel, J. W. (1996) · Human Genetics · doi:10.1007/bf02185763 · Cited by 879
Insulin signaling in health and disease
White, M. F. (2003) · Science · doi:10.1126/science.1092952 · Cited by 733
Mechanisms of aging: public or private?
Partridge, L., & Gems, D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg753 · Cited by 517

Show all 27 references

Research works printed but not linked: 1

A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, Vienna, 2008).

Sorted by citations

Items 301–400 of 570

Immunochip analysis identifies association of the RAD 50/ IL 13 region with human longevity
Flachsbart, F., Ellinghaus, D., Gentschew, L., Heinsen, F., Caliebe, A., Christiansen, L., Nygaard, M., Christensen, K., Blanché, H., Deleuze, J., et al. (2016) · Aging Cell · doi:10.1111/acel.12471 · Cited by 23
Self-citation
The expression of CG9940 affects the adaptation of cardiac function, mobility, and lifespan to exercise in aging Drosophila
Wen, D., Zheng, L., Ni, L., Wang, H., Feng, Y., & Zhang, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.006 · Cited by 23
Investigation of genetic susceptibility factors for human longevity – A targeted nonsynonymous SNP study
Flachsbart, F., Franke, A., Kleindorp, R., Caliebe, A., Blanché, H., Schreiber, S., & Nebel, A. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.08.006 · Cited by 22
Self-citation
Association analysis of common variants in FOXO3 with type 2 diabetes in a South Indian Dravidian population
Nair, A. K., Sugunan, D., Kumar, H., & Gopalakrishnapillai, A. (2011) · Gene · doi:10.1016/j.gene.2011.09.032 · Cited by 22
Epistasis, physical capacity-related genes and exceptional longevity: FNDC5 gene interactions with candidate genes FOXOA3 and APOE
Fuku, N., Díaz‐Peña, R., Arai, Y., Abe, Y., Zempo, H., Naıto, H., Murakami, H., Miyachi, M., Spuch, C., Rexach, J. A. S., et al. (2017) · BMC Genomics · doi:10.1186/s12864-017-4194-4 · Cited by 22
Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score
Torres, G. G., Dose, J., Hasenbein, T. P., Nygaard, M., Krause‐Kyora, B., Mengel‐From, J., Christensen, K., Andersen‐Ranberg, K., Kolbe, D., Lieb, W., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810949 · Cited by 20
Self-citation
FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs
Sanchis‐Gomar, F., Garatachea, N., He, Z.-H., Pareja-Galeano, H., Fuku, N., Tian, Y., Arai, Y., Abe, Y., Murakami, H., Miyachi, M., et al. (2014) · AGE · doi:10.1007/s11357-014-9733-1 · Cited by 22
Aging biology: a new frontier for drug discovery
Verdaguer, E., Junyent, F., Folch, J., Beas‐Zárate, C., Auladell, C., Pallàs, M., & Camins, A. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2012.660144 · Cited by 22
Protein synthesis as an integral quality control mechanism during ageing
Charmpilas, N., Daskalaki, I., Papandreou, M., & Tavernarakis, N. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.008 · Cited by 21
The IRS2 Gly1057Asp Variant Is Associated With Human Longevity
Barbieri, M., Rizzo, M. R., Papa, M., Boccardi, V., Esposito, A., White, M. F., & Paolisso, G. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp154 · Cited by 22
Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives
Pennuto, M., Pandey, U. B., & Polanco, M. J. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100821 · Cited by 22
Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review
Iweala, E., Adurosakin, O. E., Ugochukwu, I., Omonhinmin, C. A., Dania, O. E., & Ugbogu, E. A. (2024) · Sci · doi:10.3390/sci6020036 · Cited by 21
Drosophila as a Model to Study Metabolic Disorders
Hoffmann, J., Romey, R., Fink, C., & Roeder, T. (2013) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2013_196 · Cited by 21
The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations
Ferrario, A., Villa, F., Malovini, A. L., Araniti, F., & Puca, A. A. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-7 · Cited by 21
Parental Longevity and Diabetes Risk in the Diabetes Prevention Program
Florez, H. J., Ma, Y., Crandall, J. P., Perreault, L., Marcovina, S. M., Bray, G. A., Saudek, C. D., Barrett-Connor, E. L., & Knowler, W. C. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr114 · Cited by 21
Effect of FOXO3 and Air Pollution on Cognitive Function: A Longitudinal Cohort Study of Older Adults in China From 2000 to 2014
Ji, J. S., Liu, L., Zeng, Y., & Yan, L. L. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac016 · Cited by 25
Genome instability: Linking ageing and brain degeneration
Barzilai, A., Schumacher, B., & Shiloh, Y. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.011 · Cited by 22
SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience
Islam, M. A., Sehar, U., Sultana, O. F., Mukherjee, U., Brownell, M., Kshirsagar, S., & Reddy, P. H. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111936 · Cited by 21
The somatotropic axis may not modulate ageing and longevity in humans
Bourg, É. L. (2015) · Biogerontology · doi:10.1007/s10522-015-9632-6 · Cited by 21
Genomic Approach to Understand the Association of DNA Repair with Longevity and Healthy Aging Using Genomic Databases of Oldest‐Old Population
Kim, Y. J., Kim, H. S., & Seo, Y. R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2984730 · Cited by 20
Factors that affect the translation of dietary restriction into a longer life
von Frieling, J., & Roeder, T. (2019) · IUBMB Life · doi:10.1002/iub.2224 · Cited by 22
Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies
van den Berg, N., Rodríguez‐Girondo, M., Mandemakers, K., Janssens, A. A. P. O., Beekman, M., & Slagboom, P. E. (2020) · Aging Cell · doi:10.1111/acel.13139 · Cited by 19
Genomics of human health and aging
Kulminski, A. M., & Culminskaya, I. V. (2011) · AGE · doi:10.1007/s11357-011-9362-x · Cited by 21
FoxO3a Contributes to the Reprogramming Process and the Differentiation of Induced Pluripotent Stem Cells
Wang, Y., Tian, C., & Zheng, J. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0044 · Cited by 20
Low level of the mtDNA4977 deletion in blood of exceptionally old individuals
von Wurmb‐Schwark, N., Schwark, T., Caliebe, A., Drenske, C., Nikolaus, S., Schreiber, S., & Nebel, A. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.01.005 · Cited by 20
Self-citation
Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-Year Prospective Longitudinal Cohort Study
Ji, J. S., Liu, L., Shu, C., Yan, L. L., & Zeng, Y. (2022) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glab378 · Cited by 19
Association Study to Evaluate FoxO1 and FoxO3 Gene in CHD in Han Chinese
Zhao, Y., Yu, Y., Tian, X., Yang, X., Li, X., Jiang, F., Chen, Y., & Shi, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086252 · Cited by 18
Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population
Li, N., Luo, H., Liu, X., Ma, S., He, L., Chen, R., Fang, H., & Zhang, D. (2015) · Oncotarget · doi:10.18632/oncotarget.6627 · Cited by 19
Genetic variations in FOXO3A are associated with Bipolar Disorder without confering vulnerability for suicidal behavior
Magno, L. A. V., Santana, C. V. N., Sacramento, E. K., de Rezende, V. B., Cardoso, M. V., Maurício-da-Silva, L., Neves, F. S., de Miranda, D. M., Marco, L. A. D., Corrêa, H., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.031 · Cited by 17
Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a
Wang, F., Marshall, C. B., & Ikura, M. (2015) · Intrinsically Disordered Proteins · doi:10.1080/21690707.2015.1056906 · Cited by 21
The MitoAging Project: Single nucleotide polymorphisms (SNPs) in mitochondrial genes and their association to longevity
Castañeda, V., Haro-Vinueza, A., Salinas, I., Caicedo, A., & Méndez, M. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.06.008 · Cited by 23
Evolution of human longevity: lessons from Hydra
Nebel, A., & Bosch, T. C. G. (2012) · Aging · doi:10.18632/aging.100510 · Cited by 18
Self-citation
EAK proteins: novel conserved regulators of C. elegans lifespan
Williams, T. W., Dumas, K. J., & Hu, P. J. (2010) · Aging · doi:10.18632/aging.100214 · Cited by 18
Effects of polymorphisms in immunity-related genes on the immune system and successful aging
Ruan, Q., Qian, F., & Yu, Z. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.04.003 · Cited by 19
Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
Keowkase, R., Aboukhatwa, M. A., Adam, B.-L., Beach, J. W., Terry, A. V., Buccafussco, J. J., & Luo, Y. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-59 · Cited by 18
Whole-genome assembly and analysis of a medicinal fungus: Inonotus hispidus
Tang, S., Jin, L., Lei, P., Shao, C., Wu, S., Yang, Y., He, Y., Ren, R., & Xu, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.967135 · Cited by 17
Novel protective effect of the FOXO3 longevity genotype on mechanisms of cellular aging in Okinawans
Torigoe, T. H., Willcox, D. C., Shimabukuro, M., Higa, M., Gerschenson, M., Andrukhiv, A., Suzuki, M., Morris, B. J., Chen, R., Gojanovich, G. S., et al. (2024) · npj Aging · doi:10.1038/s41514-024-00142-8 · Cited by 18
Contemporary human genetic strategies in aging research
Bloss, C. S., Pawlikowska, L., & Schork, N. J. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.07.005 · Cited by 17
Forkhead Box(O) in Control of Reactive Oxygen Species and Genomic Stability to Ensure Healthy Lifespan
Charitou, P., & Burgering, B. M. T. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4921 · Cited by 17
Aging, Protein Aggregation, Chaperones and Neurodegenerative Disorders: Mechanisms of Coupling and Therapeutic Opportunities
Cohen, E. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10088 · Cited by 17
Genetic interplay between human longevity and metabolic pathways — a large‐scale eQTL study
Häsler, R., Venkatesh, G., Tan, Q., Flachsbart, F., Sinha, A. N., Rosenstiel, P. C., Lieb, W., Schreiber, S., Christensen, K., Christiansen, L., et al. (2017) · Aging Cell · doi:10.1111/acel.12598 · Cited by 17
Self-citation
Le vieillissement du système immunitaire : du fondamental à la clinique
Vallet, H., Fali, T., & Sauce, D. (2018) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2018.07.005 · Cited by 22
Dynamics of redox signaling in aging via autophagy, inflammation, and senescence
Javali, P. S., Sekar, M., Kumar, A., & Thirumurugan, K. (2023) · Biogerontology · doi:10.1007/s10522-023-10040-3 · Cited by 16
Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
Tain, L. S., Sehlke, R., Meilenbrock, R. L., Leech, T., Paulitz, J., Chokkalingam, M., Nagaraj, N., Grönke, S., Fröhlich, J., Atanassov, I., et al. (2021) · eLife · doi:10.7554/elife.67275 · Cited by 15
IGF-I Signaling and Effects on Longevity
Holzenberger, M. (2011) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000325914 · Cited by 16
Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B
Flachsbart, F., Möller, M., Däumer, C., Gentschew, L., Kleindorp, R., Krawczak, M., Caliebe, A., Schreiber, S., & Nebel, A. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.83 · Cited by 16
Self-citation
Copy Number Variations in Alternative Splicing Gene Networks Impact Lifespan
Glessner, J., Smith, A. V., Panossian, S., Kim, C., Takahashi, N., Thomas, K., Wang, F., Seidler, K., Harris, T. B., Launer, L. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053846 · Cited by 15
Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China
Zhang, W., Huang, Q., Kang, Y., Li, H., & Tan, G. (2022) · Aging and Disease · doi:10.14336/ad.2022.1108 · Cited by 16
Younger for Longer: Insulin Signalling, Immunity and Ageing
Amrit, F. R. G., & May, R. C. (2010) · Current Aging Science · doi:10.2174/1874609811003030166 · Cited by 15
Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders
Cohen, E., Moll, L., & Elami, T. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13917 · Cited by 15
An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients
Lamparello, A. J., Namas, R. A., Schimunek, L., Cohen, M., El-Dehaibi, F., Yin, J., Barclay, D. A., Zamora, R., Billiar, T. R., & Yoram Vodovotz, B. (2019) · Shock · doi:10.1097/shk.0000000000001411 · Cited by 14
A key control point in the T cell response to chronic infection and neoplasia: FOXO1
Marcel, N., & Hedrick, S. Μ. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.02.001 · Cited by 16
Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan
Ji, H., Qi, Z., Schrapel, D., Le, M., Luo, Y., Yan, B., Gladkich, J., Schaefer, M., Liu, L., & Herr, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.784999 · Cited by 15
rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts
Fuku, N., Díaz‐Peña, R., Arai, Y., Abe, Y., Pareja-Galeano, H., Sanchis‐Gomar, F., Santos‐Lozano, A., Zempo, H., Naıto, H., Murakami, H., et al. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.07.016 · Cited by 14
Foxo3
Dobson, M., & Tzivion, G. (2011) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a000945.01 · Cited by 14
Hydra as a tractable, long-lived model system for senescence
Bellantuono, A. J., Bridge, D. M., & Martínez, D. E. (2014) · Invertebrate Reproduction & Development · doi:10.1080/07924259.2014.938196 · Cited by 15
Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals
Flachsbart, F., Caliebe, A., Nothnagel, M., Kleindorp, R., Nikolaus, S., Schreiber, S., & Nebel, A. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.136 · Cited by 14
Self-citation
Histone H2AX Is Involved in FoxO3a-Mediated Transcriptional Responses to Ionizing Radiation to Maintain Genome Stability
Tarrade, S., Bhardwaj, T., Flegal, M., Bertrand, L., Velegzhaninov, I. O., Moskalev, A., & Klokov, D. Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226216 · Cited by 14
An association study of FOXO3 variant and longevity
Sena, G. G. S., Camporez, D., dos Santos, L. R., Silva, A. S. D., Pimassoni, L. H. S., Tieppo, A., Batitucci, M. D. C. P., Morelato, R. L., & Paula, F. (2018) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2017-0169 · Cited by 14
Bien vieillir
Brunet, A. (2012) · médecine/sciences · doi:10.1051/medsci/2012283021 · Cited by 15
Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes
Forte, G., Grossi, V., Celestini, V., Lucisano, G., Scardapane, M., Varvara, D., Patruno, M., Bagnulo, R., Loconte, D. C., Giunti, L., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-661 · Cited by 14
Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 15
Sexual dimorphism in immunity and longevity among the oldest old
Arakelyan, N. A., Kupriyanova, D. A., Vasiļevska, J., & Rogaev, E. I. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1525948 · Cited by 14
The Association Between Longevity-Associated FOXO3 Allele and Heart Disease in Septuagenarians and Octogenarians: The SONIC Study
Klinpudtan, N., Allsopp, R., Kabayama, M., Godai, K., Gondo, Y., Masui, Y., Akagi, Y., Srithumsuk, W., Sugimoto, K., Akasaka, H., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab204 · Cited by 14
Countering neurodegeneration by reducing the activity of the insulin/IGF signaling pathway: Current knowledge and future prospects
Cohen, E. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.08.032 · Cited by 13
Neurogenetic effects on cognition in aging brains: a window of opportunity for intervention?
Reinvang, I. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00143 · Cited by 13
Age-specific bone tumour incidence rates are governed by stem cell exhaustion influencing the supply and demand of progenitor cells
Richardson, R. B. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.001 · Cited by 13
IGF-1 and Reproduction in Snakes
Sparkman, A. M., Bronikowski, A. M., & Ford, N. B. (2011) · Reproductive biology and phylogeny series · doi:10.1201/b10879-16 · Cited by 13
Genetic Variation in FOXO3 is Associated with Self-Rated Health in a Population-Based Sample of Older Individuals
Zettergren, A., Kern, S., Rydén, L., Östling, S., Blennow, K., Zetterberg, H., Falk, H., & Skoog, I. G. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly021 · Cited by 13
Aging Is Accompanied by a Progressive Decrease of Expression of the WRN Gene in Human Blood Mononuclear Cells
Połosak, J., Kuryłowicz, A., Roszkowska-Gancarz, M., Owczarz, M., & Puzianowska‐Kuźnicka, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq162 · Cited by 12
Molecular evolutionary patterns of NAD+/Sirtuin aging signaling pathway across taxa
Gaur, U., Tu, J., Li, D., Gao, Y., Lian, T., Sun, B., Yang, D., Fan, X., & Yang, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182306 · Cited by 12
Candidate Genes That Affect Aging Through Protein Homeostasis
Argon, Y., & Gidalevitz, T. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_2 · Cited by 13
Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study
Gentschew, L., Flachsbart, F., Kleindorp, R., Badarinarayan, N., Schreiber, S., & Nebel, A. (2013) · Biogerontology · doi:10.1007/s10522-013-9470-3 · Cited by 12
Self-citation
Runx Family Genes in Tissue Stem Cell Dynamics
Wang, C. Q., Mok, M. M. H., Yokomizo, T., Tergaonkar, V., & Osato, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-3233-2_9 · Cited by 12
Biomedical and genetic characteristics of the Ryukyuans: demographic history, diseases and physical and physiological traits
Koganebuchi, K., & Kimura, R. (2019) · Annals of Human Biology · doi:10.1080/03014460.2019.1582699 · Cited by 12
Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice
Beaulac, H. J., Gilels, F. A., Zhang, J., Jeoung, S., & White, P. M. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03972-6 · Cited by 12
Association of FOXO3 Blood DNA Methylation with Cancer Risk, Cancer Survival, and Mortality
Yu, C., Hodge, A. M., Wong, E. M., Joo, J. E., Makalic, E., Schmidt, D. F., Buchanan, D. D., Hopper, J. L., Giles, G. G., Southey, M. C., et al. (2021) · Cells · doi:10.3390/cells10123384 · Cited by 12
Adjustment for smoking does not alter the FOXO3A association with longevity
Däumer, C., Flachsbart, F., Caliebe, A., Schreiber, S., Nebel, A., & Krawczak, M. (2013) · AGE · doi:10.1007/s11357-013-9578-z · Cited by 11
Self-citation
Pathways to decoding the clinical potential of stress response FOXO-interaction networks for Huntington's disease: of gene prioritization and context dependence
Parmentier, F., Lejeune, F., & Néri, C. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00022 · Cited by 12
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Dose, J., Nebel, A., Piegholdt, S., Rimbach, G. H., & Huebbe, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.031 · Cited by 11
Self-citation
Theorien zu Alter(n) und Gesundheit
Wurm, S., Wiest, M., & Tesch‐Römer, C. (2010) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-010-1044-9 · Cited by 13
Integration of Metabolism
Meisenberg, G., & Simmons, W. H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-323-07155-0.00030-7 · Cited by 12
The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a
Wang, S., Sun, Y. Z., Yao, L., Xing, Y., Yang, H., & Ma, Q. (2023) · Molecular Biotechnology · doi:10.1007/s12033-023-00746-7 · Cited by 11
Multifactorial processes to slowing the biological clock: Insights from a comparative approach
Sanchez, J. R., Milton, S., Corbit, K. C., & Buffenstein, R. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.08.017 · Cited by 10
Inflammation in Aging Processes
Finch, C. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-378638-8.00012-9 · Cited by 10
When less is more: the PI3K pathway as a determinant of tumor response to dietary restriction
Coffer, P. J. (2009) · Cell Research · doi:10.1038/cr.2009.81 · Cited by 10
When Testosterone Fades: Leydig Cell Aging Shaped by Environmental Toxicants, Metabolic Dysfunction, and Testicular Niche Crosstalk
Kaltsas, A., Dimitriadis, F., Zachariou, A., Koukos, S., Chrisofos, M., & Sofikitis, N. (2026) · Cells · doi:10.3390/cells15020158 · Cited by 12
Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial
Hadanny, A., Forer, R., Volodarsky, D., Daniel-Kotovsky, M., Catalogna, M., Zemel, Y., Bechor, Y., & Efrati, S. (2021) · Aging · doi:10.18632/aging.203709 · Cited by 9
FoxO3 Regulates the Progress and Development of Aging and Aging-Related Diseases
Chang, Z., He, Z., & Xia, J. (2022) · Current Molecular Medicine · doi:10.2174/1566524023666221014140817 · Cited by 10
FOXO3A ‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity
Santo, E. E., Ribel‐Madsen, R., Stroeken, P. J. M., de Boer, V. C. J., Hansen, N. S., Commandeur, M., Vaag, A. A., Versteeg, R., Paik, J., & Westerhout, E. M. (2023) · Aging Cell · doi:10.1111/acel.13763 · Cited by 10
The Biomarkers in Extreme Longevity: Insights Gained from Metabolomics and Proteomics
Qiu, X., Lu, Y., Mu, C., Tang, P., Liu, Y., Huang, Y., Luo, H., Liu, J.-Y., & Li, X. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.98778 · Cited by 9
Molekulare Ätiologie der Hautalterung
Makrantonaki, E., & Zouboulis, C. C. (2011) · Der Hautarzt · doi:10.1007/s00105-011-2136-7 · Cited by 9
Prognosis in autoimmune and infectious disease: new insights from genetics
Lee, J. C., & Smith, K. G. C. (2014) · Clinical & Translational Immunology · doi:10.1038/cti.2014.8 · Cited by 9
Analytical tools to assess aging in humans: The rise of geri-omics
da Costa, J. P., Rocha‐Santos, T., & Duarte, A. C. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.09.011 · Cited by 9
Inverse Association Between Height-Increasing Alleles and Extreme Longevity in Japanese Women
Tanisawa, K., Hirose, N., Arai, Y., Shimokata, H., Yamada, Y., Kawai, H., Kojima, M., Obuchi, S. P., Hirano, H., Suzuki, H., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx155 · Cited by 9
Involvement of SPATA31 copy number variable genes in human lifespan
Bekpen, C., Xie, C., Nebel, A., & Tautz, D. (2018) · Aging · doi:10.18632/aging.101421 · Cited by 9
Self-citation
Comparing Effects of FOXO3 and Residing in Urban Areas on Longevity: A Gene–Environment Interaction Study
Ji, J. S., Liu, L., Yan, L. L., & Zeng, Y. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab362 · Cited by 9
Aging control with resveratrol
Pallàs, M., Junyent, F., Verdaguer, E., Beas‐Zárate, C., & Camins, A. (2010) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2011.01.001 · Cited by 9
Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone
Errigo, A., Dore, M. P., Mocci, G., & Pes, G. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-80497-w · Cited by 9
Membrane ion Channels and Receptors in Animal lifespan Modulation
Sheng, Y., Tang, L., Kang, L., & Xiao, R. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25824 · Cited by 9

Authors: Flachsbart, F., Caliebe, A., Kleindorp, R., Blanché, H., von Eller-Eberstein, H., Nikolaus, S., Schreiber, S., & Nebel, A.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Institute of Medical Informatics and Statistics, and
Institute of Clinical Molecular Biology,
Fondation Jean Dausset-CEPH (FR)
Popgen Biobank, Christian-Albrechts-University, 24105 Kiel, Germany; and
Corresponding author: Schreiber, Stefan
ORCID: Caliebe, Amke
Blanché, Hélène
Nikolaus, Susanna
Schreiber, Stefan
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2009-02-24
Volume: 106
Issue: 8
Pages: 2700-2705
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0809594106
PMC: PMC2650329
OpenAlex: W1965684670
Cited by: 572
References: 27
Citations by year: 2026: 12 · 2025: 8 · 2024: 19 · 2023: 11 · 2022: 14 · 2021: 24 · 2020: 27 · 2019: 30 · 2018: 34 · 2017: 37 · 2016: 31 · 2015: 40 · 2014: 54 · 2013: 51 · 2012: 48
FWCI: 24.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/misc/userlicense.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: European Commission
Deutsche Forschungsgemeinschaft
Exzellenzclusters Entzündungsforschung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: FOXO3, human longevity, centenarians, single nucleotide polymorphisms, insulin/IGF-1 signaling, replication study, sex differences in longevity
MeSH terms: Forkhead Box Protein O3, Adolescent, Adult, Aged, Aged, 80 and over, Humans, Longevity, Middle Aged, Genetic Variation, Case-Control Studies, Polymorphism, Single Nucleotide, Forkhead Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of FOXO3A variation with human longevity confirmed in German centenarians

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks