Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development
Harding, Heather P., Zhang, Yuhong, Scheuner, Donalyn, Chen, Jane-Jane, Kaufman, Randal J., Ron, David·2009·Proceedings of the National Academy of Sciences
Cited by (266)
Items 101–200 of 266
- The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and developmentSara Morgan Wilcox, Hitesh Arora, Lonna Munro, Jian Xin, Franz Fenninger, Laura A. Johnson, Cheryl G. Pfeifer, Kyung Bok Choi, Juan Hou, Pamela A. Hoodless et al. · 2017 · PLoS ONE
- The Pancreatic ß-cell Response to Secretory Demands and Adaption to StressMichael A. Kalwat, Donalyn Scheuner, Karina Rodrigues-dos-Santos, Decio Laks Eizirik, Melanie H. Cobb · 2021 · Endocrinology
- Association with Endoplasmic Reticulum Promotes Proteasomal Degradation of GADD34 ProteinWei Zhou, Matthew Brush, Meng Shyan Choy, Shirish Shenolikar · 2011 · Journal of Biological Chemistry
- Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: Achieving specificity by targeting substrate and regulatory protein interaction sitesWolfgang Peti, Rebecca Page · 2015 · Bioorganic & Medicinal Chemistry
- A Subunit of Eukaryotic Translation Initiation Factor 2α-Phosphatase (CreP/PPP1R15B) Regulates Membrane TrafficNicole Kloft, Claudia Neukirch, Gisela von Hoven, Wiesia Bobkiewicz, Silvia Weis, Klaus Böller, Matthias Husmann · 2012 · Journal of Biological Chemistry
- The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP)Danielle Hicks, Krithika Giresh, Lisa A. Wrischnik, Douglas C. Weiser · 2023 · International Journal of Molecular Sciences
- Unfolded Protein Response of the Endoplasmic Reticulum in Tumor Progression and ImmunogenicityYoon-Seon Yoo, Hye Gyeong Han, Young Joo Jeon · 2017 · Oxidative Medicine and Cellular Longevity
- Multitrait meta-analysis identified genomic regions associated with sexual precocity in tropical beef cattle1Thaise Pinto de Melo, Marina R. S. Fortes, Tiago Bresolin, Lúcio Flávio Macêdo Mota, Lúcia Galvão de Albuquerque, Roberto Carvalheiro · 2018 · Journal of Animal Science
- Identification of deregulated genes by single wall carbon-nanotubes in human normal bronchial epithelial cellsAnas Alazzam, Etienne Mfoumou, Ion G. Stiharu, Amal Kassab, Andrew David Darnel, Amber Yasmeen, N.R. Sivakumar, Rama Bhat, Ala‐Eddin Al Moustafa · 2010 · Nanomedicine Nanotechnology Biology and Medicine
- DNA Damage Regulates Translation through β-TRCP Targeting of CRePTheresa B. Loveless, Benjamin R. Topacio, Ajay Amar Vashisht, Shastyn Galaang, Katie Ulrich, Brian D. Young, James Akira Wohlschlegel, David Paul Toczyski · 2015 · PLoS Genetics
- Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac MyocytesChristiane Neuber, June Uebeler, Thomas Schulze, Hannieh Sotoud, Ali El‐Armouche, Thomas Eschenhagen · 2014 · PLoS ONE
- Transcriptomic responses of the endangered freshwater mussel Margaritifera margaritifera to trace metal contamination in the Dronne River, FranceAnthony Bertucci, Fabien Pierron, Julien Thébault, Christophe Klopp, J. Bellec, Patrice Gonzalez, Magalie Baudrimont · 2017 · Environmental Science and Pollution Research
- IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein SynthesisJae‐Seon So, Sungyun Cho, Sang‐Hyun Min, Scot R. Kimball, Ann-Hwee Lee · 2015 · Molecular and Cellular Biology
- Control of Oncogenesis by eIF2α Phosphorylation: Implications in PTEN and PI3K–Akt Signaling and Tumor TreatmentAntonis E. Koromilas, Zineb Mounir · 2013 · Future Oncology
- Protective Unfolded Protein Response in Human Pancreatic Beta Cells Transplanted into MiceJeffrey Kennedy, Hitoshi Katsuta, Min-Ho Jung, Lorella Marselli, Allison B. Goldfine, Ulysses J. Balis, Dennis C. Sgroi, Susan Bonner‐Weir, Gordon C. Weir · 2010 · PLoS ONE
- Adaptive Basal Phosphorylation of eIF2α Is Responsible for Resistance to Cellular Stress–Induced Cell Death in Pten -Null HepatocytesNi Zeng, Yang Li, Lina He, Xiaoling Xu, Vivian A. Galicia, Chu‐Xia Deng, Bangyan L. Stiles · 2011 · Molecular Cancer Research
- Embryo collection induces transient activation of XBP1 arm of the ER stress response while embryo vitrification does notT. Abraham, Christopher L. Pin, Andrew John Watson · 2011 · Molecular Human Reproduction
- Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytesRukshar Khan, Vinitha Kadamkode, Devesh Kesharwani, Sudarshana Purkayastha, Gautam Banerjee, Malabika Datta · 2019 · RNA Biology
- The unfolded protein and integrated stress response in melanoma and vitiligoPrashiela Manga, Noshin Choudhury · 2020 · Pigment Cell & Melanoma Research
- Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylationMargarito Rojas, Anne‐Claude Gingras, Thomas E. Dever · 2014 · Proceedings of the National Academy of Sciences
- A (dis)integrated stress response: Genetic diseases of eIF2α regulatorsAlyssa M. English, Katelyn M. Green, Stephanie L. Moon · 2021 · Wiley Interdisciplinary Reviews - RNA
- Induction of CCAAT/enhancer-binding protein–homologous protein by cigarette smoke through the superoxide anion-triggered PERK–eIF2α pathwayYasuhiro Tagawa, Nobuhiko Hiramatsu, Hironori Kato, Takashi Sakoh, Shotaro Nakajima, Kunihiro Hayakawa, Yukinori Saito, Hisashi Johno, Shuhei Takahashi, Liubao Gu et al. · 2011 · Toxicology
- Pharmacological read-through of R294X Mecp2 in a novel mouse model of Rett syndromeJonathan K. Merritt, Bridget E. Collins, Kirsty R. Erickson, Hong‐Wei Dong, Jeffrey Lorenz Neul · 2020 · Human Molecular Genetics
- Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine ModelAshley Kidwell, Shiv Pratap Singh Yadav, Bernhard Maier, Amy Zollman, Kevin Ni, Arvin Halim, Danielle Janosevic, Jered Myslinski, Farooq Syed, Li‐Fan Zeng et al. · 2022 · Journal of the American Society of Nephrology
- Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress responseAleksandra P. Pitera, María Szaruga, Sew‐Yeu Peak‐Chew, Steven Wingett, Anne Bertolotti · 2022 · The EMBO Journal
- Protein Stability Buffers the Cost of Translation Attenuation following eIF2α PhosphorylationKim Schneider, Geoffrey M. Nelson, Joseph L. Watson, Jörg Morf, Maximillian M. Dalglish, Laura Martina Luh, Annika Weber, Anne Bertolotti · 2020 · Cell Reports
- Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in miceYuriko Tanaka, Sachiko Ito, Reina Oshino, Nana Chen, Naomi Nishio, Ken‐ichi Isobe · 2015 · British Journal of Cancer
- Unfolded Protein Response at the Crossroads: Integrating Endoplasmic Reticulum Stress with Cellular Stress NetworksSebastian Gawlak-Socka, Edward Kowalczyk, Anna Wiktorowska‐Owczarek · 2026 · International Journal of Molecular Sciences
- Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complexJessica Perego, Andreia V. Mendes, Clarisse Bourbon, Voahirana Camosseto, Alexis J. Combes, Hong Liu, Thien‐Phong Vu Manh, Alexandre Dalet, Lionel Chasson, Lionel Spinelli et al. · 2018 · Science Signaling
- Plin5, a New Target in Diabetic CardiomyopathyXiangning Cui, Jingwu Wang, Yang Zhang, Jian-Liang Wei, Yan Wang · 2022 · Oxidative Medicine and Cellular Longevity
- An Ancient Pseudoknot in TNF-α Pre-mRNA Activates PKR, Inducing eIF2α Phosphorylation that Potently Enhances SplicingLise Sarah Namer, Farhat Osman, Yona Banai, Benoı̂t Masquida, Rodrigo Jung, Raymond O.R. Kaempfer · 2017 · Cell Reports
- An Overview of Unfolded Protein Response Signaling and Its Role in CancerBuddhi Prakash Jain · 2017 · Cancer Biotherapy and Radiopharmaceuticals
- Metabolic injury of hepatocytes promotes progression of NAFLD and AALDCarvalho-Gontijo, Raquel, Han, Cuijuan, Zhang, Lei, Zhang, Vivian, Hosseini, Mojgan, Mekeel, Kristin, Schnabl, Bernd, Loomba, Rohit, Karin, Michael, Brenner, David A. et al. · 2022 · Seminars in Liver Disease
- Molecular Mechanisms of Sepsis-Associated Acute Kidney InjuryTakashi Hato, Pierre C. Dagher · 2025 · Journal of the American Society of Nephrology
- Impaired Embryonic Development in Mice Overexpressing the RNA-Binding Protein TIARYacine Kharraz, Pierre-Adrien Salmand, Anne Camus, Jacques Auriol, Cyril Gueydan, Véronique Kruys, Dominique Morello · 2010 · PLoS ONE
- The integrated stress response regulates BMP signalling through effects on translationElke Malzer, Caia S. Dominicus, Joseph E. Chambers, Jennifer A. Dickens, Souradip Mookerjee, Stefan John Marciniak · 2018 · BMC Biology
- Sustained OMA1-mediated integrated stress response is beneficial for spastic ataxia type 5Camilla Aurora Franchino, Martina Brughera, Valentina Baderna, Daniele De Ritis, Alessandra Rocco, Sara Seneca, Luc Régal, Paola Podini, Maurizio D’Antonio, Camilo Toro et al. · 2023 · Brain
- Targeting UPR branches, a potential strategy for enhancing efficacy of cancer chemotherapyMengchao Yu, Jie Lun, Hongwei Zhang, Lei Wang, Gang Zhang, Haisheng Zhang, Jing Susan Fang · 2021 · Acta Biochimica et Biophysica Sinica
- Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) ProteinSurojeet Sengupta, Catherine M. Sevigny, Poulomi Bhattacharya, Virgil Craig Jordan, Robert C. Clarke · 2019 · Molecular Cancer Research
- High-fat diet leads to elevated lipid accumulation and endoplasmic reticulum stress in oocytes, causing poor embryo developmentA. Chandrasekhara Rao, Aparna Satheesh, Guruprasad Nayak, Pooja Suresh Poojary, Sandhya Kumari, Sneha Guruprasad Kalthur, Srinivas Mutalik, Satish Kumar Adiga, Guruprasad Kalthur · 2020 · Reproduction Fertility and Development
- RGS2 is a component of the cellular stress responseChau H. Nguyen, Peishen Zhao, Alina J. Sobiesiak, Peter Chidiac · 2012 · Biochemical and Biophysical Research Communications
- Importance of the subcellular location of protein deposits in neurodegenerative diseasesAnne Bertolotti · 2018 · Current Opinion in Neurobiology
- Foie gras and liver regeneration: a fat dilemmaMaria Agnese Della Fazia, Giuseppe Servillo · 2018 · Cell Stress
- The role of redox signaling in mitochondria and endoplasmic reticulum regulation in kidney diseasesOmar Emiliano Aparicio‐Trejo, Estefani Yaquelin Hernández Cruz, Laura María Reyes-Fermín, Zeltzin Alejandra Ceja-Galicia, José Pedraza‐Chaverrí · 2025 · Archives of Toxicology
- Integrating genome-wide association study and pathway analysis reveals physiological aspects affecting heifer early calving defined at different ages in Nelore cattleLúcio Flávio Macêdo Mota, Alejandro B. Carvajal, Priscila Arrigucci Bernardes, Marcos Eli Buzanskas, Fernando Sebastian Baldi, Raysildo Barbosa Lôbo, Danísio Prado Munari · 2022 · Genomics
- Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cellsMehdi Amiri, Stephen J. Kiniry, Anthony P. Possemato, Niaz Mahmood, Tayebeh Basiri, Catherine R. Dufour, Negar Tabatabaei, Qiyun Deng, Michael A. Bellucci, Keerthana Harwalkar et al. · 2023 · Cell Reports
- Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitorsNahuel A. Paolini, Kat Moore, Franca M. di Summa, Ivo F.A.C. Fokkema, Peter A.C. ’t Hoen, Marieke v. Lindern · 2018 · PLoS ONE
- Roles of the Translation Initiation Factor eIF2α Phosphorylation in Cell Structure and FunctionSung Hoon Back · 2020 · Cell Structure and Function
- Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancersChunyu Liu, Liang Chen, Yukun Cong, Lulin Cheng, Yujun Shuai, Fang Lv, Kang Chen, Yarong Song, Yifei Xing · 2024 · Cell Death and Disease
- Circadian Clock Control of Translation Initiation Factor eIF2α Activity Requires eIF2γ-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassaZhaolan Ding, Teresa M. Lamb, Ahmad Boukhris, Rachel L. Porter, D. Bell-Pedersen · 2021 · mBio
- An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquatCarolina Nunes, Pranika Singh, Zahra Mazidi, Cormac Murphy, Aurore Bourguignon, Sara Wellens, Vidya Chandrasekaran, Sreya Ghosh, Melinda Zana, David Pamies et al. · 2022 · Toxicology in Vitro
- Blockade of Smad signaling by 3′-deoxyadenosine: a mechanism for its anti-fibrotic potentialLiubao Gu, Hisashi Johno, Shotaro Nakajima, Hironori Kato, Shuhei Takahashi, Ryohei Katoh, Masanori Kitamura · 2013 · Laboratory Investigation
- Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4Andreia V. Mendes, Julien Paul Gigan, Christian Rodríguez Rodrígues, Sébastien A. Choteau, Doriane Sanséau, Daniela Barros, Catarina R. Almeida, Voahirana Camosseto, Lionel Chasson, Lionel Chasson et al. · 2020 · Life Science Alliance
- The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinomaMaría Teresa Borrello, Mickenzie B. Martin, Christopher L. Pin · 2021 · Pancreatology
- Serine-threonine protein phosphatases: Lost in translationVICTORIA G. KOLUPAEVA · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Integrating stress responses and immunityPhilippe Pierre · 2019 · Science
- The role of endoplasmic reticulum stress in type 2 diabetes mellitus mechanisms and impact on islet functionZhaxicao He, Qian Liu, Yan Wang, Bing Zhao, Lumei Zhang, Xia V. Yang, Zhigang Wang · 2025 · PeerJ
- Eukaryotic Initiation Factor 2α - a Downstream Effector of Mammalian Target of Rapamycin - Modulates DNA Repair and Cancer Response to TreatmentLiron Tuval-Kochen, Shoshana Paglin, Gilmor I. Keshet, Yaniv Lerenthal, Charles T Nakar, Tamar Golani, Amos Toren, Joachim Yahalom, Raphael Pfeffer, Yaacov Richard Lawrence · 2013 · PLoS ONE
- Dephosphorylation of eIF2α is essential for protein synthesis increase and cell cycle progression after sea urchin fertilizationVlad Costache, Stefania Bilotto, Laurent Laguerre, Robert Bellé, Bertrand Cosson, Patrick Cormier, Julia Morales · 2012 · Developmental Biology
- Super enhancer acquisition drives expression of oncogenic PPP1R15B that regulates protein homeostasis in multiple myelomaSinan Xiong, Jianbiao Zhou, Tze King Tan, Tae‐Hoon Chung, Tuan Zea Tan, Sabrina Hui Min Toh, Nicole Xin Ning Tang, Yunlu Jia, Yi Xiang See, Melissa J. Fullwood et al. · 2024 · Nature Communications
- HRI protein kinase in cytoplasmic heme sensing and mitochondrial stress response: Relevance to hematological and mitochondrial diseasesJane-Jane Chen · 2025 · Journal of Biological Chemistry
- Inhibition of Nonsense-Mediated Decay Induces Nociceptive Sensitization through Activation of the Integrated Stress ResponseJune Bryan de la Peña, Rebecca Chase, Nikesh Kunder, Patrick R. Smith, Tzu‐Fang Lou, Alexander D. Stanowick, Prarthana Suresh, Tarjani N. Shukla, Samuel E. Butcher, Theodore John Price et al. · 2023 · Journal of Neuroscience
- Endoplasmic reticulum as a therapeutic target in type 2 diabetes: Role of phytochemicalsSoraya Sajadimajd, Niloofar Deravi, Kimia Forouhar, Roja Rahimi, Ali Kheirandish, Roodabeh Bahramsoltani · 2022 · International Immunopharmacology
- A Point Mutation in Translation Initiation Factor eIF2B Leads to Function- and Time-Specific Changes in Brain Gene ExpressionLiraz Marom, Igor Ulitsky, Yuval Cabilly, Ron Shamir A, Orna Elroy‐Stein · 2011 · PLoS ONE
- Regulation of the Unfolded Protein Response by eIF2Bδ IsoformsLeenus Martin, Scot R. Kimball, Lawrence B. Gardner · 2010 · Journal of Biological Chemistry
- The role of endoplasmic reticulum stress in the regulation of long noncoding RNAs in cancerNasim Ebrahimi, Jamileh Saremi, Masoud Ghanaatian, Elnaz Yazdani, Samaneh Adelian, Sahar Samsami, Neda Moradi, Nadi Rostami Ravari, Amirhossein Ahmadi, Michael Richard Hamblin et al. · 2022 · Journal of Cellular Physiology
- Emerging therapeutic strategies for transplantation-induced acute kidney injury: protecting the organelles and the vascular bedNicolas Mélis, Raphaël Thuillier, Clara Steichen, Sébastien Giraud, Ysé Sauvageon, Jacques Kaminski, Thomas Pelé, L. Badet, Jean Pierre Richer, Jonatan Barrera‐Chimal et al. · 2019 · Expert Opinion on Therapeutic Targets
- A crucial role of endoplasmic reticulum stress in cellular responses during pulmonary arterial hypertension.Ting Shuang Pan, Lei Zhang, Kang Miao, Yi Wang · 2020 · PubMed Central
- Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female miceVruti Patel, Guillaume Bidault, Joseph E. Chambers, Stefania Carobbio, Angharad J. T. Everden, Concepción Garcés, Lucy E. Dalton, Fiona Mary Gribble, Antonio Vidal‐Puig, Stefan John Marciniak · 2019 · Scientific Reports
- Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functionMelissa J. Mann, Chris Melendez-Suchi, Hannah E. Vorndran, Maria Sukhoplyasova, Ashley R. Flory, Mary Carson Irvine, Anuradha R. Iyer, Christopher J. Guerriero, Jeffrey L. Brodsky, Linda M. Hendershot et al. · 2024 · Molecular Biology of the Cell
- PP1 Phosphatase Complexes: Undruggable No LongerPaola Vagnarelli, Dario R. Alessi · 2018 · Cell
- Signaling plasticity in the integrated stress responseMorgane Boone, Francesca Zappa · 2023 · Frontiers in Cell and Developmental Biology
- Circadian Control of Protein SynthesisNathan R. James, John Stuart O'Neill · 2024 · BioEssays
- Targeting the integrated stress response in ophthalmologyHsiao-Sang Chu, Cornelia Peterson, Albert S. Jun, James William Foster · 2021 · Current Eye Research
- Multifaceted control of mRNA translation machinery in cancerLilas Alboushi, Angela P. Hackett, Parisa Naeli, Mostafa Bakhti, Seyed Mehdi Jafarnejad · 2021 · Cellular Signalling
- Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal ratsYizhong Wang, Qingxian Li, Dingmei Zhang, Liaobin Chen, Hui Wang · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress responseErnie Yulyaningsih, Jung H. Suh, Melania H. Fanok, Roni Chau, Hilda O. Solanoy, Ryan Takahashi, Anna I. Bakardjiev, Isabel A. Becerra, N. Butch Benitez, Chi‐Lu Chiu et al. · 2023 · eLife
- Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress responseYujun Chen, Jocelyn A. McDonald · 2024 · Current Biology
- ATF family members as therapeutic targets in cancer: From mechanisms to pharmacological interventionsXueyao Zhang, Zhijia Li, Xiaochun Zhang, Ziyue Yuan, Lan Zhang, Peng Miao · 2024 · Pharmacological Research
- Mycobacterium tuberculosis Rv1515c antigen enhances survival of M. smegmatis within macrophages by disrupting the host defenceWenmin Yang, Minqiang Liu, Xi Yu, Yu Huang, Jie Zeng, Yongdong Dai, Hongping Luo, Qinqin Huang, Lin Fan, Jianping Xie · 2021 · Microbial Pathogenesis
- UBXN1 maintains ER proteostasis and represses UPR activation by modulating translationBrittany A. Ahlstedt, Rakesh Ganji, Sirisha Mukkavalli, João A. Paulo, Steven P. Gygi, Malavika Raman · 2024 · EMBO Reports
- An Overview of Methods for Detecting eIF2α Phosphorylation and the Integrated Stress ResponseAgnieszka Krzyżosiak, Aleksandra P. Pitera, Anne Bertolotti · 2022 · Methods in molecular biology
- Decoding cold ischaemia time impact on kidney graft: the kinetics of the unfolded protein response pathwaysSylvain Le Pape, Ophélie Pasini-Chabot, Pierre Couturier, P. Delpech, Romain Volmer, Nathalie Quellard, Rutger J. Ploeg, Thierry Hauet, Raphaël Thuillier · 2018 · Artificial Cells Nanomedicine and Biotechnology
- PromISR-6, a Guanabenz Analogue, Improves Cellular Survival in an Experimental Model of Huntington’s DiseaseJeyapriya Rajameenakshi Sundaram, Yilong Wu, Irene Cheng Jie Lee, Simi Elizabeth George, Monalisa Hota, Sujoy Ghosh, Sashi Kesavapany, Mahmood Ahmed, Eng‐King Tan, Shirish Shenolikar · 2019 · ACS Chemical Neuroscience
- Enhanced ER protein processing gene expression increases rAAV yield and full capsid ratio in HEK293 cellsQiang Fu, Yongdan Wang, Jiansong Qin, Dongming Xie, David McNally, Seongkyu Yoon · 2024 · Applied Microbiology and Biotechnology
- Endoplasmic reticulum stress mediates osteocyte death under oxygen-glucose deprivation in vitroYizhong Wang, Bing Han, Junhui Ding, Chen Qiu, Wenbo Wang · 2020 · Acta Histochemica
- Strong TCR-mediated signals suppress integrated stress responses induced by KDELR1 deficiency in naive T cellsDaisuke Kamimura, Yasunobu Arima, Mineko Tsuruoka, Jing‐Jing Jiang, Hidenori Bando, Jie Meng, Lavannya Sabharwal, Andrea Štofková, Naoki Nishikawa, Kotaro Higuchi et al. · 2015 · International Immunology
- X-box Binding Protein 1: An Adaptor in the Pathogenesis of AtherosclerosisTao Wang, Jia Zhou, Xiao Zhang, Yujie Wu, Kehan Jin, Yilin Wang, Ran Xu, Ge Yang, Wenjing Li, Liqun Jiao · 2022 · Aging and Disease
- Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinomaKe He, Sanqi An, Fei Liu, Ye Chen, Guoan Xiang, Haihe Wang · 2023 · International Journal of Biological Sciences
- eIF2α confers cellular tolerance to S. aureus α-toxinGisela von Hoven · 2015 · Frontiers in Immunology
- Delineating the role of eIF2α in retinal degenerationChristopher R. Starr, Marina S. Gorbatyuk · 2019 · Cell Death and Disease
- Store-Operated Calcium Entry: Shaping the Transcriptional and Epigenetic Landscape in Pancreatic CancerAna P. Kutschat, Steven A. Johnsen, Feda H. Hamdan · 2021 · Cells
- Deciphering the Role of Protein Phosphatases in Apicomplexa: The Future of Innovative Therapeutics?Aline Fréville, Bénédicte Gnangnon, Asma S. Khelifa, Mathieu Gissot, Jamal Khalife, Christine Pierrot · 2022 · Microorganisms
- mir-98-5p regulates gluconeogenesis and lipogenesis by targeting PPP1R15B in hepatocytesRukshar Khan, Amit Kumar Verma, Malabika Datta · 2023 · Journal of Cell Communication and Signaling
- Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15BSaeed Mohammad, Lynne A. Wolfe, Petra Stöbe, Saskia Biskup, Mark S. Wainwright, Héctor Melín‐Aldana, Padmini Malladi, Maximilian Muenke, William Allen Gahl, Peter F. Whitington · 2016 · The Journal of Pediatrics
- Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress responseYan, Yahui, Shetty, Maithili, Harding, Heather P., George, Ginto, Zyryanova, Alisa, Labbé, Katherine, Mafi, Amirhossein, Hao, Qi, Sidrauski, Carmela, Ron, David · 2024 · Proceedings of the National Academy of Sciences
- ER stress signaling at the interphase between MASH and HCCYounis Hazari, Éric Chevet, Béatrice Bailly‐Maitre, Claudio A. Hetz · 2024 · Hepatology
- Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variantKarin Eytan, Ziv Versano, Roni Oren, Jasmine Jacob‐Hirsch, Moshe Leitner, Alon Harmelin, Gideon Rechavi, Amos Toren, Shoshana Paglin, Michal Yalon · 2022 · Frontiers in Oncology
- Protein Homeostasis Dysregulation in Pathogenesis of Neurodegenerative DiseasesMichail S. Kukharsky, M. W. Everett, Olga A Lytkina, M A Raspopova, Elena A Kovrazhkina, Р. К. Овчинников, Alexandr Antohin, Алексей Александрович Московцев · 2022 · Molecular Biology
- The small compound Icerguastat reduces muscle defects in oculopharyngeal muscular dystrophy through the PERK pathway of the unfolded protein responseRima Naït-Saïdi, Aymeric Chartier, Emmanuelle Abgueguen, Philippe Guédat, Martine Simonelig · 2023 · Open Biology