The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The generation, migration, and differentiation of olfactory neurons in the adult primate brain
Open accessAbstract
In adult rodents, neural progenitor cells in the subependymal (SZ) zone of the lateral cerebral ventricle generate neuroblasts that migrate in chains via the rostral migratory stream (RMS) into the olfactory bulb (OB), where they differentiate into interneurons. However, the existence of this neurogenic migratory system in other mammals has remained unknown. Here, we report the presence of a homologue of the rodent SZ/RMS in the adult macaque monkey, a nonhuman Old World primate with a relatively smaller OB. Our results—obtained by using combined immunohistochemical detection of a marker for DNA replication (5-bromodeoxyuridine) and several cell type-specific markers—indicate that dividing cells in the adult monkey SZ generate neuroblasts that undergo restricted chain migration over an extended distance of more than 2 cm to the OB and differentiate into granule interneurons. These findings in a nonhuman primate extend and support the use of the SZ/RMS as a model system for studying neural regenerative mechanisms in the human brain.
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Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351
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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
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C ELL M IGRATION IN THE F OREBRAIN
Marín, O., & Rubenstein, J. L. R. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131058 · Cited by 915
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Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849
Metadata
- Authors
- Kornack, D. R., & Rakic, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-04-10
- Volume
- 98
- Issue
- 8
- Pages
- 4752-4757
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042109654
- Cited by
- 424
- References
- 2
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
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