The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge
Open accessAbstract
Influenza prophylaxis would benefit from a simple method to administer influenza vaccine into skin without the need for hypodermic needles. In this study, solid metal microneedle arrays (MNs) were investigated as a system for cutaneous vaccine delivery using influenza virus antigen. The MNs with 5 monument-shaped microneedles per array were produced and coated with inactivated influenza virus A/PR/8/34 (IIV). As much as 10 μg of viral proteins could be coated onto an array of 5 microneedles, and the coated IIV was delivered into skin at high efficiency within minutes. The coated MNs were used to immunize mice in comparison with conventional intramuscular injection at the same dose. Analysis of immune responses showed that a single immunization with IIV-coated MNs induced strong antibody responses against influenza virus, with significant levels of hemagglutination inhibition activities (>1:40), which were comparable to those induced by conventional intramuscular immunization. Moreover, mice immunized by a single dose of IIV coated on MNs were effectively protected against lethal challenge by a high dose of mouse-adapted influenza virus A/PR/8/34. These results show that MNs are highly effective as a simple method of vaccine delivery to elicit protective immune responses against virus infection.
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Holland, D., Booy, R., Looze, F. D., Eizenberg, P., McDonald, J., Karrasch, J., McKeirnan, M., Salem, H., Mills, G., Reid, J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/590434 · Cited by 254
Cited by
Microneedles for drug and vaccine delivery
Kim, Y.-C., Park, J.-H., & Prausnitz, M. R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.04.005 · Cited by 1,760
Self-citationLarrañeta, E., Lutton, R. E. M., Woolfson, A. D., & Donnelly, R. F. (2016) · Materials Science and Engineering: R: Reports · doi:10.1016/j.mser.2016.03.001 · Cited by 964
Dissolving polymer microneedle patches for influenza vaccination
Sullivan, S. P., Koutsonanos, D. G., del Pilar Martin, M., Lee, J. W., Zarnitsyn, V., Choi, S.-O., Murthy, N., Compans, R. W., Skountzou, I., & Prausnitz, M. R. (2010) · Nature Medicine · doi:10.1038/nm.2182 · Cited by 948
Self-citationAldawood, F. K., Andar, A., & Desai, S. (2021) · Polymers · doi:10.3390/polym13162815 · Cited by 499
Metadata
- Authors
- Zhu, Q., Zarnitsyn, V. G., Ye, L., Wen, Z., Gao, Y., Pan, L., Skountzou, I., Gill, H. S., Prausnitz, M. R., Yang, C., & Compans, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 7968-7973
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2116085039
- Cited by
- 211
- References
- 1
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhu, Q., Zarnitsyn, V. G., Ye, L., Wen, Z., Gao, Y., Pan, L., Skountzou, I., Gill, H. S., Prausnitz, M. R., Yang, C., & Compans, R. W. (2009). Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0812652106
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