The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Characterization of the c-MYC-regulated transcriptome by SAGE: Identification and analysis of c-MYC target genes
Open accessAbstract
To identify target genes of the oncogenic transcription factor c-MYC, serial analysis of gene expression (SAGE) was performed after adenoviral expression of c- MYC in primary human umbilical vein endothelial cells: 216 different SAGE tags, corresponding to unique mRNAs, were induced, whereas 260 tags were repressed after c-MYC expression ( P < 0.05). The induction of 53 genes was confirmed by using microarray analysis and quantitative real-time PCR: among these genes was MetAP2 / p67 , which encodes an activator of translational initiation and represents a validated target for inhibition of neovascularization. Furthermore, c-MYC induced the cell cycle regulatory genes CDC2-L1 , Cyclin E binding protein 1 , and Cyclin B1 . The DNA repair genes BRCA1 , MSH2 , and APEX were induced by c-MYC, suggesting that c- MYC couples DNA replication to processes preserving the integrity of the genome. MNT , a MAX-binding antagonist of c-MYC function, was up-regulated, implying a negative feedback loop. In vivo promoter occupancy by c-MYC was detected by chromatin immunoprecipitation for CDK4 , Prohibitin , MNT , Cyclin B1 , and Cyclin E binding protein 1 , showing that these genes are direct c-MYC targets. The c-MYC-regulated genes/tags identified here will help to define the set of bona fide c-MYC targets and may have potential therapeutic value for inhibition of cancer cell proliferation, tumor-vascularization, and restenosis.
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Cites
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FOXO1 couples metabolic activity and growth state in the vascular endothelium
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Metadata
- Authors
- Menssen, A., & Hermeking, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-30
- Volume
- 99
- Issue
- 9
- Pages
- 6274-6279
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061035943
- Cited by
- 406
- References
- 38
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- green
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