Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 455

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α

Open access
Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, Eck, Michael J.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.082117899
Open this paper in CoChat — free account

Abstract

Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of HIF-1α. CH1 has a triangular geometry composed of four α-helices with three intervening Zn 2+ -coordinating centers. CH1 serves as a scaffold for folding of the HIF-1α C-terminal transactivation domain, which forms a vise-like clamp on the CH1 domain that is stabilized by extensive hydrophobic and polar interactions. The structure reveals the mechanism of specific recognition of p300 by HIF-1α, and shows how HIF-1α transactivation is regulated by asparagine hydroxylation.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.082117899

Cites

11 of 11 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 11 references

Research works printed but not linked: 32

  1. G L Semenza Trends Mol Med 7, 345–350 (2001). · DOI · Paper page
  2. S Salceda, J Caro J Biol Chem 272, 22642–22647 (1997). · DOI · Paper page
  3. A C Epstein, J M Gleadle, L A McNeill, K S Hewitson, J O'Rourke, D R Mole, M Mukherji, E Metzen, M I Wilson, A Dhanda, et al. Cell 107, 43–54 (2001). · DOI · Paper page
  4. R K Bruick, S L McKnight Science 294, 1337–1340 (2001). · DOI · Paper page
  5. Z Arany, L E Huang, R Eckner, S Bhattacharya, C Jiang, M A Goldberg, H F Bunn, D M Livingston Proc Natl Acad Sci USA 93, 12969–12973 (1996). · DOI · Paper page
  6. B L Ebert, H F Bunn Mol Cell Biol 18, 4089–4096 (1998). · DOI · Paper page
  7. P J Kallio, K Okamoto, S O'Brien, P Carrero, Y Makino, H Tanaka, L Poellinger EMBO J 17, 6573–6586 (1998). · DOI · Paper page
  8. M Ema, K Hirota, J Mimura, H Abe, J Yodoi, K Sogawa, L Poellinger, Y Fujii-Kuriyama EMBO J 18, 1905–1914 (1999). · DOI · Paper page
  9. P Carrero, K Okamoto, P Coumailleau, S O'Brien, H Tanaka, L Poellinger Mol Cell Biol 20, 402–415 (2000). · DOI · Paper page
  10. A L Kung, S Wang, J M Klco, W G Kaelin, D M Livingston Nat Med 6, 1335–1340 (2000). · DOI · Paper page
  11. N Vo, R H Goodman J Biol Chem 276, 13505–13508 (2001). · DOI · Paper page
  12. C W Pugh, J F O'Rourke, M Nagao, J M Gleadle, P J Ratcliffe J Biol Chem 272, 11205–11214 (1997). · DOI · Paper page
  13. B H Jiang, J Z Zheng, S W Leung, R Roe, G L Semenza J Biol Chem 272, 19253–19260 (1997). · DOI · Paper page
  14. S R Grossman Eur J Biochem 268, 2773–2778 (2001). · DOI · Paper page
  15. J F O'Rourke, Y M Tian, P J Ratcliffe, C W Pugh J Biol Chem 274, 2060–2071 (1999). · DOI · Paper page
  16. J Gu, J Milligan, L E Huang J Biol Chem 276, 3550–3554 (2001). · DOI
  17. R N De Guzman, H Y Liu, M Martinez-Yamout, H J Dyson, P E Wright J Mol Biol 303, 243–253 (2000). · DOI
  18. C H Lin, B J Hare, G Wagner, S C Harrison, T Maniatis, E Fraenkel Mol Cell 8, 581–590 (2001). · DOI
  19. D Neri, T Szyperski, G Otting, H Senn, K Wuthrich Biochemistry 28, 7510–7516 (1989). · DOI · Paper page
  20. H Matsuo, H Li, A M McGuire, C M Fletcher, A C Gingras, N Sonenberg, G Wagner Nat Struct Biol 4, 717–724 (1997). · DOI · Paper page
  21. P Guntert, V Dotsch, G Wider, K Wuthrich J Biomol NMR 2, 619–629 (1992). · DOI · Paper page
  22. C Bartels, T Xia, M Billeter, P Guntert, K Wuthrich J Biomol NMR 6, 1–10 (1995). · DOI · Paper page
  23. A T Brunger A System for X-Ray Crystallography and NMR, Version 3.1 (Yale Univ. Press, New Haven, CT, 1992).
  24. R C Hoffman, R X Xu, R E Klevit, J R Herriott J Magn Reson Ser B 102, 61–72 (1993). · doi:10.1006/jmrb.1993.1062
  25. L L Conte, C Chothia, J Janin J Mol Biol 285, 2177–2198 (1999). · DOI · Paper page
  26. Q P Wang, W J VanDusen, C J Petroski, V M Garsky, A M Stern, P A Friedman J Biol Chem 266, 14004–14010 (1991). · DOI
  27. A H Huber, W I Weis Cell 105, 391–402 (2001). · DOI · Paper page
  28. H J Dyson, P E Wright Curr Opin Struct Biol 12, 54–60 (2002). · DOI · Paper page
  29. S J Demarest, M Martinez-Yamout, J Chung, H Chen, W Xu, H J Dyson, R M Evans, P E Wright Nature (London) 415, 549–553 (2002). · DOI · Paper page
  30. R Koradi, M Billeter, K Wuthrich J Mol Graph 14, 51–32 (1996). · DOI · Paper page
  31. P J Kraulis J Appl Crystallogr 24, 946–950 (1991). · DOI · Paper page
  32. A Nicholls, K A Sharp, B Honig Proteins 11, 281–296 (1992). · DOI · Paper page

Cited by

See all 455

Metadata

Authors
Freedman, S. J., Sun, Z.-Y. J., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., & Eck, M. J.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2002-04-16
Volume
99
Issue
8
Pages
5367-5372
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.082117899
OpenAlex
W2006833515
Cited by
455
References
11
FWCI
10.39
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. https://app.cochat.ai/papers/10.1073/pnas.082117899
The paper
Freedman, S. J., Sun, Z.-Y. J., Poy, F., Kung, A. L., Livingston, D. M., Wagner, G., & Eck, M. J. (2002). Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.082117899

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.