The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria
Open accessAbstract
Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate animal food products. Mathematical models are an important tool for understanding the potential medical consequences of this increased exposure. We have developed a mathematical model to evaluate factors affecting the prevalence of human commensal AR bacteria that cause opportunistic infections (e.g., enterococci). Our analysis suggests that AAU hastens the appearance of AR bacteria in humans. Our model indicates that the greatest impact occurs very early in the emergence of resistance, when AR bacteria are rare, possibly below the detection limits of current surveillance methods.
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Cites
Quinolone-Resistant Campylobacter jejuni Infections in Minnesota, 1992–1998
Smith, K. E., Besser, J. M., Hedberg, C. W., Leano, F. T., Bender, J. B., Wicklund, J. H., Johnson, B. P., Moore, K. A., & Osterholm, M. T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199905203402001 · Cited by 666
Levy, S. B., FitzGerald, G. B., & Macone, A. B. (1976) · New England Journal of Medicine · doi:10.1056/nejm197609092951103 · Cited by 352
Cited by
Antibiotic resistance-the need for global solutions
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70318-9 · Cited by 4,439
Sarmah, A. K., Meyer, M. T., & Boxall, A. B. A. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.03.026 · Cited by 3,326
Food Animals and Antimicrobials: Impacts on Human Health
Marshall, B. M., & Levy, S. B. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-11 · Cited by 2,241
Wellington, E. M., Boxall, A. B., Cross, P., Feil, E. J., Gaze, W. H., Hawkey, P. M., Johnson-Rollings, A. S., Jones, D. L., Lee, N. M., Otten, W., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70317-1 · Cited by 1,122
Evidence of Increasing Antibiotic Resistance Gene Abundances in Archived Soils since 1940
Knapp, C. W., Dolfing, J., Ehlert, P. A. I., & Graham, D. W. (2010) · Environmental Science & Technology · doi:10.1021/es901221x · Cited by 837
Metadata
- Authors
- Smith, D. L., Harris, A. D., Johnson, J. A., Silbergeld, E. K., & Morris, J. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-23
- Volume
- 99
- Issue
- 9
- Pages
- 6434-6439
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109054898
- Cited by
- 463
- References
- 2
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
