The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Animal antibiotic use has an early but important impact on the emergence of antibiotic resistance in human commensal bacteria
Open accessAbstract
Antibiotic use is known to promote the development of antibiotic resistance, but substantial controversy exists about the impact of agricultural antibiotic use (AAU) on the subsequent emergence of antibiotic-resistant bacteria among humans. AAU for animal growth promotion or for treatment or control of animal diseases generates reservoirs of antibiotic-resistant (AR) bacteria that contaminate animal food products. Mathematical models are an important tool for understanding the potential medical consequences of this increased exposure. We have developed a mathematical model to evaluate factors affecting the prevalence of human commensal AR bacteria that cause opportunistic infections (e.g., enterococci). Our analysis suggests that AAU hastens the appearance of AR bacteria in humans. Our model indicates that the greatest impact occurs very early in the emergence of resistance, when AR bacteria are rare, possibly below the detection limits of current surveillance methods.
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Cites
Quinolone-Resistant Campylobacter jejuni Infections in Minnesota, 1992–1998
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Sarmah, A. K., Meyer, M. T., & Boxall, A. B. A. (2006) · Chemosphere · doi:10.1016/j.chemosphere.2006.03.026 · Cited by 3,326
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Marshall, B. M., & Levy, S. B. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-11 · Cited by 2,241
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Knapp, C. W., Dolfing, J., Ehlert, P. A. I., & Graham, D. W. (2010) · Environmental Science & Technology · doi:10.1021/es901221x · Cited by 837
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747
Kaplan, J. B., Izano, E. A., Gopal, P., Karwacki, M. T., Kim, S., Bose, J. L., Bayles, K. W., & Horswill, A. R. (2012) · mBio · doi:10.1128/mbio.00198-12 · Cited by 287
Overview of emerging contaminants and associated human health effects
Lei, M., Zhang, L., Lei, J., Zong, L., Li, J., Wu, Z., & Wang, Z. (2015) · BioMed Research International · doi:10.1155/2015/404796 · Cited by 231
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A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine
Scott, K. A., Qureshi, M. H., Cox, P. B., Marshall, C. M., Bellaire, B. C., Wilcox, M., Stuart, B. A. R., & Njardarson, J. T. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01502 · Cited by 56
Metadata
- Authors
- Smith, D. L., Harris, A. D., Johnson, J. A., Silbergeld, E. K., & Morris, J. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-23
- Volume
- 99
- Issue
- 9
- Pages
- 6434-6439
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2109054898
- Cited by
- 463
- References
- 2
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
