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Cited by 334Motor Control and AdaptationMemory and Neural MechanismsVestibular and auditory disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Modular organization of internal models of tools in the human cerebellum

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Imamizu, Hiroshi, Kuroda, Tomoe, Miyauchi, Satoru, Yoshioka, Toshinori, Kawato, Mitsuo·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0835746100PMC PMC154367
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Abstract

Human capabilities in manipulating many different tools with dexterity suggest modular neural organization at functional levels, but anatomical modularity underlying the capabilities has yet to be demonstrated. Although modularity in phylogenetically older parts of the cerebellum is well known, comparable modularity in the lateral cerebellum for cognitive functions remains unknown. We investigated these issues by functional MRI (fMRI) based on our previous findings of a cerebellar internal model of a tool. After subjects intensively learned to manipulate two novel tools (the rotated mouse whose cursor appeared at a rotated position, and the velocity mouse whose cursor velocity was proportional to the mouse position), they could easily switch between the two. The lateral and posterior cerebellar activities for the two different tools were spatially segregated, and their overlaps were <10%, even at low statistical thresholds. Activities of the rotated mouse were more anterior and lateral than the velocity mouse activities. These results were consistent with predictions by the MOdular Selection And Identification Controller (MOSAIC) model that multiple internal models compete to partition sensory-motor experiences and their outputs are linearly combined for a particular context.

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Research works printed but not linked: 4

  1. S Paradiso, N C Andreasen, D S O'Leary, S Arndt, R G Robinson Neuropsychiat Neuropsychol Behav Neurol 10, 1–8 (1997).
  2. M Ito The Cerebellum and Neural Motor Control (Raven, New York, 1984).
  3. S Higuchi, H Imamizu, M Kawato NeuroImage 16, s847 (2002).
  4. D Purves Neuroscience (Sinauer, Sunderland, MA, 2001).

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Metadata

Authors
Imamizu, H., Kuroda, T., Miyauchi, S., Yoshioka, T., & Kawato, M.
Affiliations
Advanced Telecommunications Research Institute International (JP)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-04-18
Volume
100
Issue
9
Pages
5461-5466
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0835746100
PMC
PMC154367
OpenAlex
W2110514514
Cited by
334
References
38
Citations by year
2026: 4 · 2025: 29 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 14 · 2014: 18 · 2013: 16 · 2012: 13
FWCI
8.00
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
cerebellum, internal models, tool handling, lateral cerebellum, posterior cerebellum, tool switching, mosaic model, sensorimotor learning, functional segregation
MeSH terms
Adult, Animals, Cerebellum, Female, Humans, Magnetic Resonance Imaging, Male, Models, Biological, Regression Analysis, Mice

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