The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin
Open accessAbstract
The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis. Here, we report a biosynthetic gene cluster for thiocillin and establish that it, and by extension the whole class, is ribosomally synthesized. Remarkably, the C-terminal 14 residues of a 52-residue peptide precursor undergo 13 posttranslational modifications to give rise to thiocillin, making this antibiotic the most heavily posttranslationally-modified peptide known to date.
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Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians
Donia, M. S., Hathaway, B. J., Sudek, S., Haygood, M. G., Rosovitz, M. J., Ravel, J., & Schmidt, E. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio829 · Cited by 261
Cited by
Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., et al. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20085f · Cited by 2,076
Self-citationBacteriocins—A viable alternative to antibiotics?
Cotter, P. D., Ross, R. P., & Hill, C. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2937 · Cited by 1,793
Genomic basis for natural product biosynthetic diversity in the actinomycetes
Nett, M., Ikeda, H., & Moore, B. S. (2009) · Natural Product Reports · doi:10.1039/b817069j · Cited by 757
Donia, M. S., Cimermancic, P., Schulze, C. J., Wieland Brown, L. C., Martin, J., Mitreva, M., Clardy, J., Linington, R. G., & Fischbach, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.08.032 · Cited by 705
Self-citationNatural Products Version 2.0: Connecting Genes to Molecules
Walsh, C. T., & Fischbach, M. A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909118a · Cited by 468
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Metadata
- Authors
- Wieland Brown, L. C., Acker, M. G., Clardy, J., Walsh, C. T., & Fischbach, M. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-02-24
- Volume
- 106
- Issue
- 8
- Pages
- 2549-2553
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2146630893
- Cited by
- 189
- References
- 2
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Wieland Brown, L. C., Acker, M. G., Clardy, J., Walsh, C. T., & Fischbach, M. A. (2009). Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0900008106
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