The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Identification of IL-17-producing FOXP3+regulatory T cells in humans
Open accessAbstract
IL-17–producing CD4+T helper (Th17) cells have recently been defined as a unique subset of proinflammatory helper cells whose development depends on signaling initiated by IL-6 and TGF-β, autocrine activity of IL-21, activation of STAT3, and induction of the orphan nuclear receptor RORγt. The maintenance, expansion, and further differentiation of the committed Th17 cells depend on IL-1β and IL-23. IL-17 was originally found produced by circulating human CD45RO+memory T cells. A recent study found that human Th17 memory cells selectively express high levels of CCR6. In this study, we report that human peripheral blood and lymphoid tissue contain a significant number of CD4+FOXP3+T cells that express CCR6 and have the capacity to produce IL-17 upon activation. These cells coexpress FOXP3 and RORγt transcription factors. The CD4+FOXP3+CCR6+IL-17–producing cells strongly inhibit the proliferation of CD4+responder T cells. CD4+CD25 high-derived T-cell clones express FOXP3, RORγt, and IL-17 and maintain their suppressive function via a cell-cell contact mechanism. We further show that human CD4+FOXP3+CCR6−regulatory T (Treg) cells differentiate into IL-17 producer cells upon T-cell receptor stimulation in the presence of IL-1β, IL-2, IL-21, IL-23, and human serum. This, together with the finding that human thymus does not contain IL-17–producing Treg cells, suggests that the IL-17+FOXP3+Treg cells are generated in the periphery. IL-17–producing Treg cells may play critical roles in antimicrobial defense, while controlling autoimmunity and inflammation.
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Cites
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
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Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
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Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
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Cited by
Plasticity of CD4+ T Cell Lineage Differentiation
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Self-citationA Validated Regulatory Network for Th17 Cell Specification
Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160
Self-citationHuman FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
Wing, J. B., Tanaka, A., & Sakaguchi, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.020 · Cited by 726
Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
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Metadata
- Authors
- Voo, K. S., Wang, Y.-H., Santori, F. R., Boggiano, C., Wang, Y.-H., Arima, K., Bover, L., Hanabuchi, S., Khalili, J., Marinova, E., Zheng, B., Littman, D. R., & Liu, Y.-J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-03-24
- Volume
- 106
- Issue
- 12
- Pages
- 4793-4798
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2142877732
- Cited by
- 689
- References
- 14
- FWCI
- 31.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Voo, K. S., Wang, Y.-H., Santori, F. R., Boggiano, C., Wang, Y.-H., Arima, K., Bover, L., Hanabuchi, S., Khalili, J., Marinova, E., Zheng, B., Littman, D. R., & Liu, Y.-J. (2009). Identification of IL-17-producing FOXP3+regulatory T cells in humans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0900408106
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