Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

Safety, activity, and immune correlates of anti–PD-1 antibody in cancer

Topalian, S. L., Hodi, F. S., Brahmer, J. R., Gettinger, S. N., Smith, D. C., McDermott, D. F., Powderly, J. D., Carvajal, R. D., Sosman, J. A., Atkins, M. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200690 · Cited by 12,628 · see citing works

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187 · see citing works

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

The Immune Landscape of Cancer

Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T.-H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.023 · Cited by 5,870 · see citing works

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835 · see citing works

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608 · see citing works

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1027 · Cited by 5,294 · see citing works

Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

Charoentong, P., Finotello, F., Angelova, M., Mayer, C., Efremova, M., Rieder, D., Hackl, H., & Trajanoski, Z. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.019 · Cited by 5,041 · see citing works

Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion

Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956 · see citing works

An essential role for Scurfin in CD4+CD25+ T regulatory cells

Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860 · see citing works

Lymphoproliferative Disorders with Early Lethality in Mice Deficient in <i>Ctla-4</i>

Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., & Mak, T. W. (1995) · Science · doi:10.1126/science.270.5238.985 · Cited by 2,766 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606 · see citing works

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Hoadley, K. A., Yau, C., Hinoue, T., Wolf, D. M., Lazar, A. J., Drill, E., Shen, R., Taylor, A. M., Cherniack, A. D., Thorsson, V., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.022 · Cited by 2,546 · see citing works

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z., Berzins, S. P., Turley, S. J., von Boehmer, H., Bronson, R. T., Dierich, A., Benoist, C. O., et al. (2002) · Science · doi:10.1126/science.1075958 · Cited by 2,488 · see citing works

Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,375 · see citing works

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291 · see citing works

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4

Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., & Sakaguchi, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.303 · Cited by 2,233 · see citing works

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,080 · see citing works

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Azizi, E., Carr, A. J., Plitas, G., Cornish, A. E., Konopacki, C., Prabhakaran, S., Nainys, J., Wu, K., Kiseliovas, V., Setty, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.060 · Cited by 1,976 · see citing works

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916 · see citing works

Regulatory T cells in cancer immunotherapy

Tanaka, A., & Sakaguchi, S. (2017) · Cell Research · doi:10.1038/cr.2016.151 · Cited by 1,860 · see citing works

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,827 · see citing works

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Jordan, M. S., Boesteanu, A. C., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A., & Caton, A. J. (2001) · Nature Immunology · doi:10.1038/86302 · Cited by 1,661 · see citing works

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J., & Sakaguchi, S. (1998) · International Immunology · doi:10.1093/intimm/10.12.1969 · Cited by 1,566 · see citing works

Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Sakaguchi, S., Ono, M., Setoguchi, R., Yagi, H., Hori, S., Fehervari, Z. T., Shimizu, J., Takahashi, T., & Nomura, T. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00427.x · Cited by 1,547 · see citing works

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells

Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · see citing works

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

Shimizu, J., Yamazaki, S., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5211 · Cited by 1,491 · see citing works

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

Simpson, T. R., Li, F., Montalvo-Ortiz, W., Sepulveda, M. A., Bergerhoff, K., Arce, F., Roddie, C., Henry, J. Y., Yagita, H., Wolchok, J. D., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130579 · Cited by 1,472 · see citing works

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

Thornton, A. M., Korty, P. E., Tran, D. Q., Wohlfert, E. A., Murray, P. E., Belkaid, Y., & Shevach, E. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904028 · Cited by 1,382 · see citing works

Foxp3+ follicular regulatory T cells control the germinal center response

Linterman, M. A., Pierson, W., Lee, S. K., Kallies, A., Kawamoto, S., Rayner, T. F., Srivastava, M., Divekar, D. P., Beaton, L., Hogan, J. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2425 · Cited by 1,292 · see citing works

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258 · see citing works

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · see citing works

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y., Shimizu, J., Otsuka, F., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5317 · Cited by 1,209 · see citing works

Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1

Champiat, S., Dercle, L., Ammari, S., Massard, C., Hollebecque, A., Postel-Vinay, S. C., Chaput, N., Eggermont, A. M. M., Marabelle, A., Soria, J., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1741 · Cited by 1,188 · see citing works

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170 · see citing works

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, J. A., & Takayanagi, H. (2014) · Nature Medicine · doi:10.1038/nm.3432 · Cited by 1,153 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

Foxp3-dependent programme of regulatory T-cell differentiation

Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127 · see citing works

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2426 · Cited by 1,120 · see citing works

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Bluestone, J. A., Buckner, J. H., Fitch, M., Gitelman, S. E., Gupta, S., Hellerstein, M. K., Herold, K. C., Lares, A., Lee, M. R., Li, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad4134 · Cited by 1,033 · see citing works

Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti–Cytotoxic T-Lymphocyte Antigen-4

Attia, P., Phan, G. Q., Maker, A. V., Robinson, M. R., Quezado, M. M., Yang, J. C., Sherry, R. M., Topalian, S. L., Kammula, U. S., Royal, R. E., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.205 · Cited by 1,012 · see citing works

Transient expression of FOXP3 in human activated nonregulatory CD4 ⁺ T cells

Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011 · see citing works

The alarmin IL-33 promotes regulatory T-cell function in the intestine

Schiering, C., Krausgruber, T., Chomka, A., Fröhlich, A., Adelmann, K., Wohlfert, E. A., Pott, J., Griseri, T., Bollrath, J., Hegazy, A. N., et al. (2014) · Nature · doi:10.1038/nature13577 · Cited by 1,007 · see citing works

CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

Chaudhry, A., Rudra, D., Treuting, P., Samstein, R. M., Liang, Y., Kas, A., & Rudensky, A. Y. (2009) · Science · doi:10.1126/science.1172702 · Cited by 1,000 · see citing works

Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

Salama, P. R., Phillips, M. R., Grieu, F., Morris, M. J., Zeps, N., Joseph, D. J., Platell, C. F. E., & Iacopetta, B. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7229 · Cited by 992 · see citing works

A Distinct Function of Regulatory T Cells in Tissue Protection

Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991 · see citing works

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958 · see citing works

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

Chatila, T. A., Blaeser, F., Ho, N. Y., Lederman, H. M., Voulgaropoulos, C., Helms, C., & Bowcock, A. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11679 · Cited by 937 · see citing works

Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

Lutsiak, M. E. C., Semnani, R. T., De Pascalis, R., Kashmiri, S. V. S., Schlom, J., & Sabzevari, H. (2005) · Blood · doi:10.1182/blood-2004-06-2410 · Cited by 903 · see citing works

Individual intestinal symbionts induce a distinct population of RORγ ⁺ regulatory T cells

Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., et al. (2015) · Science · doi:10.1126/science.aaa9420 · Cited by 879 · see citing works

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Saito, T., Nishikawa, H., Wada, H., Nagano, Y., Sugiyama, D., Atarashi, K., Maeda, Y., Hamaguchi, M., Ohkura, N., Sato, E., et al. (2016) · Nature Medicine · doi:10.1038/nm.4086 · Cited by 871 · see citing works

The microbiota regulates type 2 immunity through RORγt ⁺ T cells

Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., et al. (2015) · Science · doi:10.1126/science.aac4263 · Cited by 863 · see citing works

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells

Selby, M. J., Engelhardt, J. J., Quigley, M., Henning, K. A., Chen, T., Srinivasan, M., & Korman, A. J. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0013 · Cited by 857 · see citing works

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

Kuehn, H. S., Ouyang, W., Lo, B., Deenick, E. K., Niemela, J. E., Avery, D. T., Schickel, J., Tran, D. Q., Stoddard, J. L., Zhang, Y., et al. (2014) · Science · doi:10.1126/science.1255904 · Cited by 854 · see citing works

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

Schubert, D., Bode, C., Kenefeck, R., Hou, T. Z., Wing, J. B., Kennedy, A., Bulashevska, A., Petersen, B., Schäffer, A. A., Grüning, B. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3746 · Cited by 835 · see citing works

DNA methylation controls Foxp3 gene expression

Polansky, J. K., Kretschmer, K., Freyer, J., Floess, S., Garbe, A. I., Baron, U., Olek, S., Hamann, A., von Boehmer, H., & Huehn, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838105 · Cited by 787 · see citing works

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

Walker, L. S. K., & Sansom, D. M. (2011) · Nature reviews. Immunology · doi:10.1038/nri3108 · Cited by 786 · see citing works

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works

Stability of the Regulatory T Cell Lineage in Vivo

Rubtsov, Y. P., Niec, R. E., Josefowicz, S., Li, L., Darce, J., Mathis, D., Benoist, C., & Rudensky, A. Y. (2010) · Science · doi:10.1126/science.1191996 · Cited by 730 · see citing works

Foxp3 + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

Onishi, Y., Fehervari, Z. T., Yamaguchi, T., & Sakaguchi, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711106105 · Cited by 716 · see citing works

Regulatory T cells in cancer immunotherapy

Nishikawa, H., & Sakaguchi, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.12.005 · Cited by 702 · see citing works

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

Plitas, G., Konopacki, C., Wu, K., Bos, P. D., Morrow, M., Putintseva, E. V., Chudakov, D. M., & Rudensky, A. Y. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.032 · Cited by 695 · see citing works

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells

Baron, U., Floess, S., Wieczorek, G., Baumann, K., Grützkau, A., Dong, J., Thiel, A., Boeld, T. J., Hoffmann, P., Edinger, M., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200737594 · Cited by 694 · see citing works

Identification of IL-17-producing FOXP3 + regulatory T cells in humans

Voo, K. S., Wang, Y., Santori, F. R., Boggiano, C., Wang, Y.-H., Arima, K., Bover, L. C., Hanabuchi, S., Khalili, J. S., Marinova, E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900408106 · Cited by 693 · see citing works

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T., & Sakaguchi, S. (2007) · Nature · doi:10.1038/nature05673 · Cited by 692 · see citing works

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

De Simone, M., Arrigoni, A., Rossetti, G., Gruarin, P., Ranzani, V., Politano, C., Bonnal, R. J. P., Provasi, E., Sarnicola, M. L., Panzeri, I., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.021 · Cited by 687 · see citing works

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Ali, N., Zirak, B., Rodriguez, R. S., Pauli, M. L., Truong, H.-A., Lai, K., Ahn, R., Corbin, K., Lowe, M. M., Scharschmidt, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.002 · Cited by 680 · see citing works

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

Lo, B., Zhang, K., Lü, W., Zheng, L., Zhang, Q., Kanellopoulou, C., Zhang, Y., Liu, Z., Fritz, J. M., Marsh, R. A., et al. (2015) · Science · doi:10.1126/science.aaa1663 · Cited by 678 · see citing works

Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.

Hill, J., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D., & Benoist, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.010 · Cited by 671 · see citing works

A Two-Step Process for Thymic Regulatory T Cell Development

Lio, C. J., & Hsieh, C. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.021 · Cited by 663 · see citing works

Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells, evoking antitumor immune responses in humans

Sugiyama, D., Nishikawa, H., Maeda, Y., Nishioka, M., Tanemura, A., Katayama, I., Ezoe, S., Kanakura, Y., Sato, E., Fukumori, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316796110 · Cited by 629 · see citing works

tTregs, pTregs, and iTregs: similarities and differences

Shevach, E. M., & Thornton, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12160 · Cited by 609 · see citing works

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

Cretney, E., Xin, A., Shi, W., Minnich, M., Masson, F., Miasari, M., Belz, G. T., Smyth, G. K., Busslinger, M., Nutt, S. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2006 · Cited by 605 · see citing works

Ipilimumab-dependent cell-mediated cytotoxicity of regulatory T cells ex vivo by nonclassical monocytes in melanoma patients

Romano, E., Kusio-Kobialka, M., Foukas, P. G., Baumgaertner, P., Meyer, C., Ballabeni, P., Michielin, O., Weide, B., Romero, P., & Speiser, D. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417320112 · Cited by 601 · see citing works

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

Wollenberg, I., Agua‐Doce, A., Hernández, A., Almeida, C. F., Oliveira, V. G., Faro, J., & Graça, L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101328 · Cited by 599 · see citing works

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Arce Vargas, F., Furness, A. J. S., Litchfield, K., Joshi, K., Rosenthal, R., Ghorani, E., Solomon, I., Lesko, M. H., Ruef, N., Roddie, C., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.010 · Cited by 592 · see citing works

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar‐Sterle, S., Masters, S. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3085 · Cited by 556 · see citing works

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works

Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery

Ito, T., Hanabuchi, S., Wang, Y.-H., Park, W. R., Arima, K., Bover, L. C., Qin, F. X.-F., Gilliet, M. F., & Liu, Y. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.018 · Cited by 541 · see citing works

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine

Kim, K. S., Hong, S., Han, D., Yi, J., Jung, J., Yang, B., Lee, J. Y., Lee, M., & Surh, C. D. (2016) · Science · doi:10.1126/science.aac5560 · Cited by 541 · see citing works

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

Hsieh, C., Zheng, Y., Liang, Y., Fontenot, J. D., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1318 · Cited by 540 · see citing works

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

Ali, K., Soond, D. R., Piñeiro, R., Hagemann, T., Pearce, W. P., Lim, E. L., Bouabe, H., Scudamore, C. L., Hancox, T. C., Maecker, H. L., et al. (2014) · Nature · doi:10.1038/nature13444 · Cited by 530 · see citing works

Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

López‐Herrera, G., Tampella, G., Pan‐Hammarström, Q., Herholz, P., Trujillo-Vargas, C. M., Phadwal, K., Simon, A. K., Moutschen, M. P., Etzioni, A., Mory, A., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.04.015 · Cited by 521 · see citing works

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

Kuswanto, W. F., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y. C., Wagers, A. J., Benoist, C. O., & Mathis, D. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 509 · see citing works

Negative selection — clearing out the bad apples from the T-cell repertoire

Palmer, E. (2003) · Nature reviews. Immunology · doi:10.1038/nri1085 · Cited by 505 · see citing works

Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

Nishimura, H. (1998) · International Immunology · doi:10.1093/intimm/10.10.1563 · Cited by 500 · see citing works

Regulatory T cell development in the absence of functional Foxp3

Lin, W. X., Haribhai, D., Relland, L. M., Truong, N., Carlson, M. R. J., Williams, C. B., & Chatila, T. A. (2007) · Nature Immunology · doi:10.1038/ni1445 · Cited by 485 · see citing works

IL-17–producing human peripheral regulatory T cells retain suppressive function

Bériou, G., Costantino, C. M., Ashley, C. W., Yang, L., Kuchroo, V. K., Baecher‐Allan, C., & Hafler, D. A. (2009) · Blood · doi:10.1182/blood-2008-10-183251 · Cited by 482 · see citing works

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., & Sakaguchi, S. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.200509402092c · Cited by 477 · see citing works

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472 · see citing works

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

Sage, P. T., Francisco, L. M., Carman, C. V., & Sharpe, A. H. (2012) · Nature Immunology · doi:10.1038/ni.2496 · Cited by 469 · see citing works

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells

Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., & Sakaguchi, S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050940 · Cited by 465 · see citing works

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

Bulliard, Y., Jolicoeur, R., Windman, M., Rue, S. M., Ettenberg, S. A., Knee, D. A., Wilson, N. S., Dranoff, G., & Brogdon, J. L. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130573 · Cited by 446 · see citing works

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

deLeeuw, R., Kost, S., Kakal, J., & Nelson, B. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-3216 · Cited by 444 · see citing works

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

Kim, H.-J., Barnitz, R. A., Kreslavsky, T., Brown, F. D., Moffett, H., Lemieux, M. E., Kaygusuz, Y., Meissner, T., Holderried, T. A. W., Chan, S., et al. (2015) · Science · doi:10.1126/science.aad0616 · Cited by 441 · see citing works

Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood

Kimmig, S., Przybylski, G. K., Schmidt, C. A., Laurisch, K., Möwes, B., Radbruch, A., & Thiel, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011756 · Cited by 439 · see citing works

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

McClymont, S. A., Putnam, A. L., Lee, M. R., Esensten, J. H., Liu, W., Hulme, M. A., Hoffmüller, U., Baron, U., Olek, S., Bluestone, J. A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003099 · Cited by 428 · see citing works

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

Feng, Y., Arvey, A., Chinen, T., van der Veeken, J., Gasteiger, G., & Rudensky, A. Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.031 · Cited by 422 · see citing works

MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells

Baecher‐Allan, C., Wolf, E., & Hafler, D. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4622 · Cited by 420 · see citing works

Umbilical cord blood–derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., et al. (2015) · Blood · doi:10.1182/blood-2015-06-653667 · Cited by 416 · see citing works

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

Vargas, F. A., Furness, A. J. S., Solomon, I., Joshi, K., Mekkaoui, L., Lesko, M. H., Miranda, E., Dahan, R., Georgiou, A., Śledzińska, A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.013 · Cited by 415 · see citing works

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413 · see citing works

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Bailey-Bucktrout, S. L., Martínez‐Llordella, M., Zhou, X., Anthony, B. A., Rosenthal, W. L., Luche, H., Fehling, H. J., & Bluestone, J. A. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.016 · Cited by 399 · see citing works

Stability and function of regulatory T cells expressing the transcription factor T-bet

Levine, A. G., Mendoza, A., Hemmers, S., Moltedo, B., Niec, R. E., Schizas, M., Hoyos, B. E., Putintseva, E. V., Chaudhry, A., Dikiy, S., et al. (2017) · Nature · doi:10.1038/nature22360 · Cited by 394 · see citing works

Autoreactive T Cells in Healthy Individuals

Danke, N. A., Koelle, D. M., Yee, C., Beheray, S., & Kwok, W. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5967 · Cited by 377 · see citing works

CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3⁺ regulatory T cells in gastric cancer

Mizukami, Y., Kono, K., Kawaguchi, Y., Akaike, H., Kamimura, K., Sugai, H., & Fujii, H. (2008) · International Journal of Cancer · doi:10.1002/ijc.23392 · Cited by 374 · see citing works

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

Kitagawa, Y., Ohkura, N., Kidani, Y., Vandenbon, A., Hirota, K., Kawakami, R., Yasuda, K., Motooka, D., Nakamura, S., Kondo, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3646 · Cited by 372 · see citing works

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (T regs ) with Minimal Loss of in Vivo Functional Activity

Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H., Bromberg, J. S., Levine, B. L., Riley, J. L., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001809 · Cited by 367 · see citing works

Control of Foxp3 stability through modulation of TET activity

Yue, X., Trifari, S., Äijö, T., Tsagaratou, A., Pastor, W. A., Zepeda-Martínez, J. A., Lio, C.-W. J., Li, X., Huang, Y., Vijayanand, P., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151438 · Cited by 355 · see citing works

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

Miyara, M., Gorochov, G., Ehrenstein, M. R., Musset, L., Sakaguchi, S., & Amoura, Z. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.05.004 · Cited by 342 · see citing works

A peripheral circulating compartment of natural naive CD4 Tregs

Valmori, D., Merlo, A., Souleimanian, N. E., Hesdorffer, C. S., & Ayyoub, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23963 · Cited by 319 · see citing works

Immune homeostasis enforced by co-localized effector and regulatory T cells

Liu, Z., Gerner, M. Y., van Panhuys, N., Levine, A. G., Rudensky, A. Y., & Germain, R. N. (2015) · Nature · doi:10.1038/nature16169 · Cited by 318 · see citing works

Plasticity of CD4+ FoxP3+ T cells

Zhou, X., Bailey-Bucktrout, S. L., Jeker, L. T., & Bluestone, J. A. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.007 · Cited by 317 · see citing works

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

Gottschalk, R. A., Corse, E., & Allison, J. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102964 · Cited by 310 · see citing works

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

Yu, W., Jiang, N. J., Ebert, P. J. R., Kidd, B. A., Müller, S., Lund, P. J., Juang, J., Adachi, K., Tse, T., Birnbaum, M. E., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.001 · Cited by 301 · see citing works

Regulatory T-cells in autoimmune diseases: Challenges, controversies and—yet—unanswered questions

Grant, C. R., Liberal, R., Mieli‐Vergani, G., Vergani, D., & Longhi, M. S. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.10.012 · Cited by 292 · see citing works

Persistence of naive CD45RA+ regulatory T cells in adult life

Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., & de Saint Groth, B. F. (2006) · Blood · doi:10.1182/blood-2005-06-2403 · Cited by 284 · see citing works

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

Li, X., Liang, Y., Leblanc, M., Benner, C. W., & Zheng, Y. (2014) · Cell · doi:10.1016/j.cell.2014.07.030 · Cited by 268 · see citing works

A Low Interleukin-2 Receptor Signaling Threshold Supports the Development and Homeostasis of T Regulatory Cells

Yu, A., Zhu, L., Altman, N. H., & Malek, T. R. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.014 · Cited by 263 · see citing works

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

Fuhrman, C. A., Yeh, W.-I., Seay, H. R., Lakshmi, P. S., Chopra, G., Zhang, L., Perry, D. J., McClymont, S., Yadav, M., Lopez, M.-C., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402381 · Cited by 262 · see citing works

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

Koch, M. A., Thomas, K. R., Perdue, N., Smigiel, K. S., Srivastava, S., & Campbell, D. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.031 · Cited by 254 · see citing works

Prevalence of Newly Generated Naive Regulatory T Cells (Treg) Is Critical for Treg Suppressive Function and Determines Treg Dysfunction in Multiple Sclerosis

Haas, J., Fritzsching, B., Trübswetter, P., Korporal, M., Milkova, L., Fritz, B., Vobis, D., Krammer, P. H., Suri‐Payer, E., & Wildemann, B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1322 · Cited by 250 · see citing works

CCR4 as a novel molecular target for immunotherapy of cancer

Ishida, T., & Ueda, R. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00307.x · Cited by 248 · see citing works

Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions

Yamaguchi, T., Wing, J. B., & Sakaguchi, S. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.10.002 · Cited by 236 · see citing works

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

Klocke, K., Sakaguchi, S., Holmdahl, R., & Wing, K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603892113 · Cited by 232 · see citing works

Enhanced Suppressor Function of TIM-3+ FoxP3+ Regulatory T cells

Gautron, A., Dominguez-Villar, M., deMarcken, M., & Hafler, D. A. (2014) · European Journal of Immunology · doi:10.1002/eji.201344392 · Cited by 224 · see citing works

Spatially selective depletion of tumor-associated regulatory T cells with near-infrared photoimmunotherapy

Sato, K., Sato, N., Xu, B., Nakamura, Y., Nagaya, T., Choyke, P. L., Hasegawa, Y., & Kobayashi, H. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6843 · Cited by 215 · see citing works

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

Paterson, A. M., Lovitch, S. B., Sage, P. T., Juneja, V. R., Lee, Y., Trombley, J. D., Arancibia-Cárcamo, C. V., Sobel, R. A., Rudensky, A. Y., Kuchroo, V. K., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141030 · Cited by 212 · see citing works

A distinct subpopulation of CD25 ⁻ T-follicular regulatory cells localizes in the germinal centers

Wing, J. B., Kitagawa, Y., Locci, M., Hume, H., Tay, C., Morita, T., Kidani, Y., Matsuda, K., Inoue, T., Kurosaki, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705551114 · Cited by 211 · see citing works

Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage

Malchow, S., Leventhal, D. S., Lee, V., Nishi, S., Socci, N. D., & Savage, P. A. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.009 · Cited by 207 · see citing works

Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody

Ha, D., Tanaka, A., Kibayashi, T., Tanemura, A., Sugiyama, D., Wing, J. B., Lim, E. L., Teng, K. W. W., Adeegbe, D., Newell, E. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812186116 · Cited by 205 · see citing works

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism

Trotta, E., Bessette, P. H., Silveria, S. L., Ely, L. K., Jude, K. M., Le, D. T., Holst, C. R., Coyle, A. J., Potempa, M., Lanier, L. L., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0070-2 · Cited by 200 · see citing works

Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals

Maeda, Y., Nishikawa, H., Sugiyama, D., Ha, D., Hamaguchi, M., Saito, T., Nishioka, M., Wing, J. B., Adeegbe, D. O., Katayama, I., et al. (2014) · Science · doi:10.1126/science.aaa1292 · Cited by 200 · see citing works

Controlled Local Delivery of CTLA-4 Blocking Antibody Induces CD8+ T-Cell–Dependent Tumor Eradication and Decreases Risk of Toxic Side Effects

Fransen, M. F., van der Sluis, T. C., OSSENDORP, F. A., Arens, R., & Melief, C. J. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0781 · Cited by 198 · see citing works

Phenotypic and Functional Analysis of CD4+CD25−Foxp3+ T Cells in Patients with Systemic Lupus Erythematosus

Bonelli, M. M., Savitskaya, A., Steiner, C.-W., Rath, E., Smolen, J. S., & Scheinecker, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1689 · Cited by 195 · see citing works

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

Takahashi, R., Nishimoto, S., Muto, G., Sekiya, T., Tamiya, T., Kimura, A., Morita, R., Asakawa, M., Chinen, T., & Yoshimura, A. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110428 · Cited by 188 · see citing works

Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

Nakagawa, H., Sido, J. M., Reyes, E. E., Kiers, V., Cantor, H., & Kim, H.-J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604765113 · Cited by 176 · see citing works

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

Pesenacker, A. M., Bending, D., Ursu, S., Wu, Q., Nistala, K., & Wedderburn, L. R. (2013) · Blood · doi:10.1182/blood-2012-08-443473 · Cited by 175 · see citing works

Multiple treg suppressive modules and their adaptability

Wing, J. B., & Sakaguchi, S. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00178 · Cited by 165 · see citing works

Regulation of Trafficking Receptor Expression in Human Forkhead Box P3+ Regulatory T Cells

Lim, H. W., Broxmeyer, H. E., & Kim, C. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.2.840 · Cited by 164 · see citing works

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells

Szurek, E. A., Cebula, A., Wojciech, Ł., Pietrzak, M., Rempała, G. A., Kisielow, P., & Ignatowicz, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141161 · Cited by 164 · see citing works

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

Halim, L., Romano, M., McGregor, R., Corrêa, I., Pavlidis, P., Grageda, N., Hoong, S.-J., Yüksel, M., Jassem, W., Hannen, R. F., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.079 · Cited by 162 · see citing works

Lineage stability and phenotypic plasticity of Foxp3+ regulatory T cells

Hori, S. (2014) · Immunological Reviews · doi:10.1111/imr.12175 · Cited by 160 · see citing works

Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans

Miyara, M., Chader, D., Sage, É., Sugiyama, D., Nishikawa, H., Bouvry, D., Claër, L., Hingorani, R., BALDERAS, R. S., Rohrer, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508224112 · Cited by 157 · see citing works

Human blood T fr cells are indicators of ongoing humoral activity not fully licensed with suppressive function

Fonseca, V. R., Agua‐Doce, A., Maceiras, A. R., Pierson, W., Ribeiro, F., Romão, V. C., Pires, A. R., Silva, S. L., Fonseca, J. E., Sousa, A. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan1487 · Cited by 150 · see citing works

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells

O’Gorman, W. E., Dooms, H., Thorne, S. H., Kuswanto, W. F., Simonds, E. F., Krutzik, P. O., Nolan, G. P., & Abbas, A. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900691 · Cited by 150 · see citing works

Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

Mason, G. M., Lowe, K., Melchiotti, R., Ellis, R., de Rinaldis, E., Peakman, M., Heck, S., Lombardi, G., & Tree, T. I. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500703 · Cited by 147 · see citing works

CCR8 Expression Identifies CD4 Memory T Cells Enriched for FOXP3+ Regulatory and Th2 Effector Lymphocytes

Soler, D. F., Chapman, T. R., Poisson, L., Wang, L., Cote-Sierra, J., RYAN, M. S., McDonald, A. A., Badola, S., Fedyk, E. R., Coyle, A. J., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.6940 · Cited by 141 · see citing works

CD49d provides access to “untouched” human Foxp3+ Treg free of contaminating effector cells

Kleinewietfeld, M., Starke, M., Mitri, D. D., Borsellino, G., Battistini, L., Rötzschke, O., & Falk, K. (2008) · Blood · doi:10.1182/blood-2008-04-150524 · Cited by 140 · see citing works

Targeting CCR8 Induces Protective Antitumor Immunity and Enhances Vaccine-Induced Responses in Colon Cancer

Villarreal, D. O., L'Huillier, A., Armington, S., Mottershead, C., Filippova, E. V., Coder, B., Petit, R. G., & Princiotta, M. F. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1119 · Cited by 139 · see citing works

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation

Morikawa, H., Ohkura, N., Vandenbon, A., Itoh, M., Nagao-Sato, S., Kawaji, H., Lassmann, T., Carninci, P., Hayashizaki, Y., Forrest, A. R. R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312717110 · Cited by 137 · see citing works

Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

Cuadrado, E., van den Biggelaar, M., de Kivit, S., Chen, Y.-Y., Slot, M., Doubal, I., Meijer, A., van Lier, R. A. W., Borst, J., & Amsen, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.008 · Cited by 132 · see citing works

Circulating Follicular Regulatory T Cells Are Defective in Multiple Sclerosis

Dhaeze, T., Peelen, E., Hombrouck, A., Peeters, L. M., Wijmeersch, B. V., Lemkens, N., Lemkens, P., Somers, V. A., Lucas, S., Broux, B., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500759 · Cited by 131 · see citing works

Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells

Bin Dhuban, K., d’Hennezel, E., Nashi, E., Bar-Or, A., Rieder, S., Shevach, E. M., Nagata, S., & Piccirillo, C. A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401803 · Cited by 117 · see citing works

Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

Yamaguchi, T., Kishi, A., Osaki, M., Morikawa, H., Martín, P. P., Wing, K., Saito, T., & Sakaguchi, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307185110 · Cited by 109 · see citing works

Molecular control of regulatory T cell development and function

Kitagawa, Y., & Sakaguchi, S. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.002 · Cited by 106 · see citing works

Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis

Shabaneh, T. B., Molodtsov, A. K., Steinberg, S. M., Zhang, P., Torres, G. M., Mohamed, G. A., Boni, A., Curiel, T. J., Angeles, C. V., & Turk, M. J. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0365 · Cited by 103 · see citing works

Increased Circulating Follicular Treg Cells Are Associated With Lower Levels of Autoantibodies in Patients With Rheumatoid Arthritis in Stable Remission

Liu, C., Wang, D., Lu, S., Xu, Q., Жао, Л., Zhao, J., Song, Y., & Wang, H. (2018) · Arthritis & Rheumatology · doi:10.1002/art.40430 · Cited by 101 · see citing works

Comment on “Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells”

Verhagen, J., & Wraith, D. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1090105 · Cited by 100 · see citing works

The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus

Golding, A., Hasni, S., Illei, G. G., & Shevach, E. M. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38119 · Cited by 99 · see citing works

The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis

Morita, T., Shima, Y., Wing, J. B., Sakaguchi, S., Ogata, A., & Kumanogoh, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162306 · Cited by 98 · see citing works

Neoantigen Targeting—Dawn of a New Era in Cancer Immunotherapy?

Wirth, T. C., & Kühnel, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01848 · Cited by 98 · see citing works

Targeting Treg signaling for the treatment of autoimmune diseases

Spence, A. L., Klementowicz, J. E., Bluestone, J. A., & Tang, Q. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.09.002 · Cited by 93 · see citing works

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Ferreira, R. C., Simons, H. Z., Thompson, W. S., Rainbow, D. B., Yang, X., Cutler, A. J., de Oliveira, J. J., Dopico, X. C., Smyth, D. J., Yarkoni, N. S., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.07.009 · Cited by 89 · see citing works

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus

Kluger, M. A., Melderis, S., Nosko, A., Goerke, B., Luig, M., Meyer, M. C., Turner, J., Meyer‐Schwesinger, C., Wegscheid, C., Tiegs, G., et al. (2015) · Kidney International · doi:10.1038/ki.2015.296 · Cited by 87 · see citing works

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Dong, S., Maiella, S., Xhaard, A., Pang, Y., Wenandy, L., Larghero, J., Bécavin, C., Benecke, A., Bianchi, E., Socié, G., et al. (2013) · Blood · doi:10.1182/blood-2013-02-482539 · Cited by 79 · see citing works

Stat3 Programs Th17-Specific Regulatory T Cells to Control GN

Kluger, M. A., Luig, M., Wegscheid, C., Goerke, B., Paust, H., Brix, S. R., Yan, I., Mittrücker, H., Hagl, B., Renner, E. D., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013080904 · Cited by 72 · see citing works

Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

Ogawa, C., Bankoti, R., Nguyen, T., Hassanzadeh‐Kiabi, N., Nadeau, S., Porritt, R. A., Couse, M., Fan, X., Dhall, D., Eberl, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.016 · Cited by 72 · see citing works

CD45RA Distinguishes CD4+CD25+CD127−/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression

Hornero, R. A., Betts, G. J., Sawitzki, B., Vogt, K., Harden, P., & Wood, K. J. (2016) · Transplantation · doi:10.1097/tp.0000000000001278 · Cited by 69 · see citing works

Human Memory Helios− FOXP3+ Regulatory T Cells (Tregs) Encompass Induced Tregs That Express Aiolos and Respond to IL-1β by Downregulating Their Suppressor Functions

Raffin, C., Pignon, P., Celse, C., Debien, E., Valmori, D., & Ayyoub, M. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301378 · Cited by 63 · see citing works

Inducing and Administering Tregs to Treat Human Disease

Perdigoto, A. L., Chatenoud, L., Bluestone, J. A., & Herold, K. C. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00654 · Cited by 50 · see citing works

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar‐Sterle, S., Masters, S. L., et al. (2015) · Nature Immunology · doi:10.1038/ni0515-544d · Cited by 47 · see citing works

A nonimmune function of T cells in promoting lung tumor progression

Green, J. A., Arpaia, N., Schizas, M., Dobrin, A., & Rudensky, A. Y. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170356 · Cited by 46 · see citing works

Erratum: Corrigendum: Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2015) · Nature Immunology · doi:10.1038/ni0515-544a · Cited by 11 · see citing works

Pathophysiology of Inflammatory Bowel Diseases

Chang, J. T. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2002697 · Cited by 1,295 · see citing works

Regulatory T Cells and Human Disease

Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,133 · see citing works

T cells in health and disease

Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,057 · see citing works

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

Kamada, T., Togashi, Y., Tay, C., Ha, D., Sasaki, A., Nakamura, Y., Sato, E., Fukuoka, S., Tada, Y., Tanaka, A., et al. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1822001116 · Cited by 905 · see citing works

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

Li, C., Jiang, P., Wei, S., Xu, X., & Wang, J. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01234-1 · Cited by 935 · see citing works

Chemokines and the immune response to cancer

Ozga, A. J., Chow, M. T., & Luster, A. D. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.012 · Cited by 846 · see citing works

Regulatory mechanisms of PD-1/PD-L1 in cancers

Lin, X., Kang, K., Chen, P., Zeng, Z., Li, G., Xiong, W., Yi, M., & Xiang, B. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02023-w · Cited by 850 · see citing works

Cold and hot tumors: from molecular mechanisms to targeted therapy

Wu, B., Zhang, B., Li, B., Wu, H., & Jiang, M. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01979-x · Cited by 751 · see citing works

Pathogenesis of autoimmune disease

Pisetsky, D. S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00720-1 · Cited by 656 · see citing works

NF‐κB signaling in inflammation and cancer

Zhang, T., Ma, C., Zhang, Z., Zhang, H., & Hu, H. (2021) · MedComm · doi:10.1002/mco2.104 · Cited by 615 · see citing works

Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets

Tie, Y., Tang, F., Wei, Y.-Q., & Wei, X.-W. (2022) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-022-01282-8 · Cited by 591 · see citing works

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

Huang, H., Wang, Z., Zhang, Y., Pradhan, R. N., Ganguly, D., Chandra, R., Murimwa, G., Wright, S., Gu, X., Maddipati, R., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.011 · Cited by 542 · see citing works

Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

Wang, H., Zhang, H., Wang, Y., Brown, Z. J., Xia, Y., Huang, Z., Shen, C., Hu, Z., Beane, J., Ansa-Addo, E. A., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.07.032 · Cited by 398 · see citing works

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

Liu, S., Liu, J., Wang, Y., Deng, F., & Deng, Z. (2025) · MedComm · doi:10.1002/mco2.70268 · Cited by 435 · see citing works

Inducing immune tolerance with dendritic cell-targeting nanomedicines

Cifuentes‐Rius, A., Desai, A., Yuen, D., Johnston, A. P. R., & Voelcker, N. H. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-00810-2 · Cited by 299 · see citing works

The functional crosstalk between myeloid-derived suppressor cells and regulatory T cells within the immunosuppressive tumor microenvironment

Haist, M., Stege, H., Grabbe, S., & Bros, M. (2021) · Cancers · doi:10.3390/cancers13020210 · Cited by 295 · see citing works

B Cell Function in the Tumor Microenvironment

Downs‐Canner, S., Meier, J. A., Vincent, B. G., & Serody, J. S. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101220-015603 · Cited by 290 · see citing works

The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

Zou, Y., Ye, F., Kong, Y., Hu, X., Deng, X., Xie, J., Song, C., Ou, X., Wu, S., Wu, L., et al. (2022) · Advanced Science · doi:10.1002/advs.202203699 · Cited by 281 · see citing works

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Zhao, P., Wang, M., Chen, M., Chen, Z., Peng, X., Zhou, F., Song, J., & Qu, J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120142 · Cited by 263 · see citing works

CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease

Gómez-Bris, R., Saéz, Á., Herrero‐Fernández, B., Rius, C., Sánchez-Martinez, H., & González, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032696 · Cited by 254 · see citing works

Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

Bar‐Or, A., & Li, R. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00063-6 · Cited by 243 · see citing works

CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity

Moreno Ayala, M. A., Campbell, T. F., Zhang, C., Dahan, N., Bockman, A., Prakash, V., Feng, L., Sher, T., & DuPage, M. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.003 · Cited by 241 · see citing works

Immune checkpoint inhibitor–associated myocarditis: manifestations and mechanisms

Moslehi, J., Lichtman, A. H., Sharpe, A. H., Galluzzi, L., & Kitsis, R. N. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145186 · Cited by 237 · see citing works

The Complex Role of Regulatory T Cells in Immunity and Aging

Rocamora‐Reverte, L., Melzer, F. L., Würzner, R., & Weinberger, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.616949 · Cited by 230 · see citing works

CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory

Kidani, Y., Nogami, W., Yasumizu, Y., Kawashima, A., Tanaka, A., Sonoda, Y., Tona, Y., Nashiki, K., Matsumoto, R., Hagiwara, M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114282119 · Cited by 212 · see citing works

Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation

Fueyo, A. S., Whitehouse, G. P., Grageda, N., Cramp, M., Lim, T. Y., Romano, M., Thirkell, S., Lowe, K., Fry, L., Heward, J., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15700 · Cited by 208 · see citing works

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Marangoni, F., Zhakyp, A., Corsini, M., Geels, S. N., Carrizosa, E., Thelen, M., Mani, V., Pruessmann, J. N., Warner, R. D., Ozga, A. J., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.027 · Cited by 201 · see citing works

Immunology of Inflammatory Bowel Disease: Molecular Mechanisms and Therapeutics

Lu, Q., Yang, M.-F., Liang, Y.-J., Xu, J., Xu, H.-M., Nie, Y.-Q., Wang, L.-S., Yao, J., & Li, D.-F. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353038 · Cited by 211 · see citing works

Follicular regulatory T cells produce neuritin to regulate B cells

González-Figueroa, P., Roco, J. A., Papa, I., Núñez-Villacís, L., Stanley, M., Linterman, M. A., Dent, A. L., Cañete, P. F., & Vinuesa, C. G. (2021) · Cell · doi:10.1016/j.cell.2021.02.027 · Cited by 168 · see citing works

CD8+ T cell exhaustion and cancer immunotherapy

Wang, Q., Qin, Y., & Li, B. (2023) · Cancer Letters · doi:10.1016/j.canlet.2022.216043 · Cited by 155 · see citing works

Regulatory T cells in immune checkpoint blockade antitumor therapy

Zhang, A., Fan, T., Liu, Y., Yu, G., Li, C., & Jiang, Z. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02156-y · Cited by 153 · see citing works

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity

You, S., Li, S., Zeng, L., Song, J., Li, Z., Li, W., Ni, H., Xu, X., Deng, W., Li, H., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.06.014 · Cited by 154 · see citing works

Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

Kotla, N. G., Bonam, S. R., Rasala, S., Wankar, J., Bohara, R. A., Bayry, J., Rochev, Y. A., & Pandit, A. S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.07.002 · Cited by 148 · see citing works

N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells

Liu, Z., Zheng, N., Li, J., Li, C., Zheng, D., Jiang, X., Ge, X., Liu, M., Liu, L., Song, Z., et al. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100886 · Cited by 147 · see citing works

Immune-Mediated Diseases Associated With Cancer Risks

He, M.-M., Lo, C., Wang, K., Polychronidis, G., Wang, L. Y., Zhong, R., Knudsen, M. D., Fang, Z., & Song, M. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.5680 · Cited by 145 · see citing works

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

Qiu, Y., Chen, T., Hu, R., Zhu, R., Li, C., Ruan, Y., Xie, X., & Li, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00327-3 · Cited by 134 · see citing works

Adjunct Immunotherapies for the Management of Severely Ill COVID-19 Patients

Bonam, S. R., Kaveri, S. V., Sakuntabhai, A., Gilardin, L., & Bayry, J. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100016 · Cited by 130 · see citing works

The gut ecosystem and immune tolerance

Shao, T., Hsu, R., Rafizadeh, D. L., Wang, L., Bowlus, C. L., Kumar, N., Mishra, J., Timilsina, S., Ridgway, W. M., Gershwin, M. E., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103114 · Cited by 136 · see citing works

Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients

Harden, P., Game, D. S., Sawitzki, B., van der Net, J. B., Hester, J., Bushell, A., Issa, F., Brook, M. O., Alzhrani, A., Schlickeiser, S., et al. (2020) · American Journal of Transplantation · doi:10.1111/ajt.16395 · Cited by 127 · see citing works

HIF-2α is indispensable for regulatory T cell function

Hsu, T.-S., Lin, Y.-L., Wang, Y.-A., Mo, S.-T., Chi, P.-Y., Lai, A. C.-Y., Pan, H.-Y., Chang, Y.-J., & Lai, M.-Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18731-y · Cited by 126 · see citing works

Nano-enhanced immunotherapy: Targeting the immunosuppressive tumor microenvironment

Jin, Y., Huang, Y., Ren, H., Huang, H., Lai, C., Wang, W., Tong, Z., Zhang, H., Wu, W., Liu, C., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2023.122463 · Cited by 129 · see citing works

Recent developments in immunotherapy for gastrointestinal tract cancers

Chong, X., Madeti, Y., Cai, J., Li, W., Cong, L., Lu, J., Mo, L., Liu, H., He, S., Yu, C., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01578-x · Cited by 129 · see citing works

Human FOXP3 and tumour microenvironment

Wang, J., Gong, R., Zhao, C., Lei, K., Sun, X., & Ren, H. (2022) · Immunology · doi:10.1111/imm.13520 · Cited by 123 · see citing works

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

Muhammad, S., Fan, T. T., Hai, Y., Gao, Y., & He, J. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01826-7 · Cited by 124 · see citing works

The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy

Wang, X., Wang, F., Zhong, M., Yarden, Y., & Fu, L. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01200-x · Cited by 120 · see citing works

Tolerogenic nanoparticles suppress central nervous system inflammation

Kenison, J. E., Jhaveri, A. M., Li, Z., Khadse, N., Tjon, E. C., Tezza, S., Nowakowska, D., Plasencia, A., Stanton, V. P., Sherr, D. H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016451117 · Cited by 109 · see citing works

Epithelial and stromal co-evolution and complicity in pancreatic cancer

Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108 · see citing works

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells

Cook, L. E., Stahl, M., Han, X., Nazli, A., MacDonald, K. N., Wong, M. Q., Tsai, K., Dizzell, S. E., Jacobson, K., Bressler, B. L., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.002 · Cited by 103 · see citing works

Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases

Ohkura, N., Yasumizu, Y., Kitagawa, Y., Tanaka, A., Nakamura, Y., Motooka, D., Nakamura, S., Okada, Y., & Sakaguchi, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.006 · Cited by 105 · see citing works

CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

Imura, Y., Ando, M., Kondo, T., Ito, M., & Yoshimura, A. (2020) · JCI Insight · doi:10.1172/jci.insight.136185 · Cited by 100 · see citing works

Metabolic interplay: tumor macrophages and regulatory T cells

Vilbois, S., Xu, Y., & Ho, P. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.11.007 · Cited by 97 · see citing works

MHC Class II Presentation in Autoimmunity

Ishina, I. A., Zakharova, M. Y., Kurbatskaia, I. N., Mamedov, A. E., Belogurov, A. A., & Gabibov, A. G. (2023) · Cells · doi:10.3390/cells12020314 · Cited by 95 · see citing works

Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression

Quandt, J., Arnovitz, S., Haghi, L., Woehlk, J., Mohsin, A., Okoreeh, M. K., Mathur, P., Emmanuel, A. O., Osman, A., Krishnan, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00889-2 · Cited by 92 · see citing works

The Immune Privilege of Cancer Stem Cells: A Key to Understanding Tumor Immune Escape and Therapy Failure

Galassi, C., Musella, M., Manduca, N., Maccafeo, E., & Sistigu, A. (2021) · Cells · doi:10.3390/cells10092361 · Cited by 91 · see citing works

Potential of regulatory T-cell-based therapies in the management of severe COVID-19

Victor, E. S., Das, M., Karnam, A., Pitard, B., Gautier, J., & Bayry, J. (2020) · European Respiratory Journal · doi:10.1183/13993003.02182-2020 · Cited by 90 · see citing works

Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity

Passeri, L., Fortunato, M., Bassi, V., & Gregori, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168415 · Cited by 89 · see citing works

Contribution of adaptive immunity to human COPD and experimental models of emphysema

Kheradmand, F., Zhang, Y., & Corry, D. B. (2022) · Physiological Reviews · doi:10.1152/physrev.00036.2021 · Cited by 87 · see citing works

Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus

Guo, C., Liu, Q., Zong, D., Zhang, W., Zuo, Z.-Q., Yu, Q., Sha, Q., Zhu, L., Gao, X., Fang, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111606 · Cited by 86 · see citing works

Temperature sensitive liposome based cancer nanomedicine enables tumour lymph node immune microenvironment remodelling

Fu, S., Chang, L., Liu, S., Gao, T., Sang, X., Zhang, Z., Mu, W., Liu, X., Liang, S., Yang, H. K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38014-6 · Cited by 86 · see citing works

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials

Zeng, L., Yang, T., Yang, K., Yu, G., Li, J., Wang, X., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.896476 · Cited by 85 · see citing works

T cell-intrinsic STING signaling promotes regulatory T cell induction and immunosuppression by upregulating FOXP3 transcription in cervical cancer

Ni, H., Zhang, H., Li, L., Huang, H., Guo, H., Zhang, L., Li, C., Xu, J.-X., Nie, C.-P., Li, K., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-005151 · Cited by 85 · see citing works

The progress and prospect of regulatory T cells in autoimmune diseases.

Zhang, X.-M., Olsen, N., & Zheng, S.-G. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102461 · Cited by 76 · see citing works

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma

Chen, J., Liu, K., Luo, Y., Kang, M., Wang, J., Chen, G., Qi, J., Wu, W., Wang, B., Han, Y., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.03.008 · Cited by 84 · see citing works

cGAS-STING signaling in the tumor microenvironment

Liu, Z., Wang, D., Zhang, J., Xiang, P., Zeng, Z., Xiong, W., & Shi, L. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216409 · Cited by 85 · see citing works

Proenkephalin + regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function

Shime, H., Odanaka, M., Tsuiji, M., Matoba, T., Imai, M., Yasumizu, Y., Uraki, R., Minohara, K., Watanabe, M., Bonito, A. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000372117 · Cited by 83 · see citing works

Striking a balance: new perspectives on homeostatic dendritic cell maturation

Bosteels, V., & Janssens, S. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01079-5 · Cited by 81 · see citing works

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

Tseng, W.-Y., Huang, Y.-S., Clanchy, F. I. L., McNamee, K., Perocheau, D. P. B., Ogbechi, J., Luo, S., Feldmann, M., McCann, F. E., & Williams, R. O. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909687116 · Cited by 82 · see citing works

Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species

Karakus, U., Şahin, D., Mittl, P. R. E., Mooij, P., Koopman, G., & Boyman, O. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb9283 · Cited by 82 · see citing works

A perspective on HPK1 as a novel immuno-oncology drug target

Sawasdikosol, S., & Burakoff, S. J. (2020) · eLife · doi:10.7554/elife.55122 · Cited by 80 · see citing works

Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration

Li, J., Wang, S., Wang, N., Zheng, Y., Yang, B., Wang, X., Zhang, J., Pan, B., & Wang, Z. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00775-2 · Cited by 80 · see citing works

Combining Cancer Vaccines with Immunotherapy: Establishing a New Immunological Approach

Kim, C.-G., Sang, Y. B., Lee, J. H., & Chon, H. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158035 · Cited by 77 · see citing works

Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application

Henschel, P., Landwehr-Kenzel, S., Engels, N., Schienke, A., Kremer, J., Riët, T., Redel, N., Iordanidis, K., Saetzler, V., John, K., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103057 · Cited by 76 · see citing works

Age-Related Changes in Thymic Central Tolerance

Srinivasan, J., Lancaster, J. N., Singarapu, N., Hale, L. P., Ehrlich, L. I. R., & Richie, E. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676236 · Cited by 67 · see citing works

Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

de Kivit, S., Mensink, M., Hoekstra, A. T., Berlin, I., Derks, R. J. E., Both, D., Aslam, M. A., Amsen, D., Berkers, C. R., & Borst, J. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00271-w · Cited by 68 · see citing works

Psoriasis: Recent progress in molecular‐targeted therapies

Honma, M., & Hayashi, K. (2021) · The Journal of Dermatology · doi:10.1111/1346-8138.15727 · Cited by 68 · see citing works

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

Liu, K., Kong, L., Cui, H., Zhang, L., Xin, Q., Zhuang, Y., Guo, C., Yao, Y., Tao, J., Gu, X., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101751 · Cited by 72 · see citing works

Targeting adenosine and regulatory T cells in cancer immunotherapy

Churov, A. V., & Жулай, Г. А. (2021) · Human Immunology · doi:10.1016/j.humimm.2020.12.005 · Cited by 67 · see citing works

Regulation of T cells by myeloid-derived suppressor cells: emerging immunosuppressor in lung cancer

He, Z., Zhang, C., Zhao, Y., He, S., Li, Y., Shi, B., Hu, J., Qi, R., & Hua, B. (2023) · Discover Oncology · doi:10.1007/s12672-023-00793-1 · Cited by 66 · see citing works

Cellular Signaling Pathways in Medium and Large Vessel Vasculitis

Watanabe, R., Berry, G. J., Liang, D. H., Goronzy, J. J., & Weyand, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.587089 · Cited by 65 · see citing works

Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

Zemmour, D., Charbonnier, L., Léon, J., Six, E. M., Keleş, S., Delville, M., Benamar, M., Barış, S., Zuber, J., Chen, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00910-8 · Cited by 65 · see citing works

Exosomes Derived from Immune Cells: The New Role of Tumor Immune Microenvironment and Tumor Therapy

Wang, S., & Shi, Y. X. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s388604 · Cited by 64 · see citing works

Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies

Kishimoto, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00969 · Cited by 63 · see citing works

Tumor microenvironment of cancer stem cells: Perspectives on cancer stem cell targeting

Guo, Q., Zhou, Y., Xie, T., Yin, Y., Li, H., Shi, W., Zheng, L., Li, X., & Zhang, W. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.05.024 · Cited by 61 · see citing works

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics

Raeber, M. E., Caspar, D., Zurbuchen, Y., Guo, N., Schmid, J., Michler, J., Martin, A. C., Steiner, U. C., Moor, A. E., Koning, F., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.07.016 · Cited by 61 · see citing works

Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy

Wang, D., Fu, B., Shen, X., Guo, C., Liu, Y., Zhang, J., Sun, R., Ye, Y., Li, J., Tian, Z., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00776-0 · Cited by 60 · see citing works

Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein

de Picciotto, S., DeVita, N., Hsiao, C. J., Honan, C., Tse, S., Nguyen, M., Ferrari, J. D., Zheng, W., Wipke, B. T., & Huang, E. (2022) · Nature Communications · doi:10.1038/s41467-022-31130-9 · Cited by 60 · see citing works

Boosting regulatory T cell function for the treatment of autoimmune diseases – That’s only half the battle!

Schlöder, J., Shahneh, F. Z., Schneider, F.-J., & Wieschendorf, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.973813 · Cited by 60 · see citing works

Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches

Hasan, A., Al‐Ozairi, E., Albaqsumi, Z., Ahmad, R., & Al‐Mulla, F. (2021) · ImmunoTargets and Therapy · doi:10.2147/itt.s280706 · Cited by 56 · see citing works

Spatially resolved transcriptomics reveal the determinants of primary resistance to immunotherapy in NSCLC with mature tertiary lymphoid structures

Peyraud, F., Guégan, J., Rey, C., Lara, O., Odin, O., Castillo, M. D., Vanhersecke, L., Coindre, J., Clot, E., Brunet, M., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101934 · Cited by 58 · see citing works

Control of foreign Ag‐specific Ab responses by Treg and Tfr

Wing, J. B., Lim, E. L., & Sakaguchi, S. (2020) · Immunological Reviews · doi:10.1111/imr.12888 · Cited by 58 · see citing works

New insights into checkpoint inhibitor immunotherapy and its combined therapies in hepatocellular carcinoma: from mechanisms to clinical trials

Jin, H., Qin, S., He, J., Xiao, J., Li, Q., Mao, Y., & Zhao, L. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.70691 · Cited by 58 · see citing works

Targeting Bone Tumor and Subcellular Endoplasmic Reticulum via Near Infrared II Fluorescent Polymer for Photodynamic‐Immunotherapy to Break the Step‐Reduction Delivery Dilemma

Zhang, X., Wan, J., Mo, F., Tang, D., Xiao, H., Li, Z., Jia, J., & Liu, T. (2022) · Advanced Science · doi:10.1002/advs.202201819 · Cited by 57 · see citing works

Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation

Vergani, B., Sandrone, G., Marchini, M., Ripamonti, C., Cellupica, E., Galbiati, E., Caprini, G., Pavich, G., Porro, G., Rocchio, I., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01194 · Cited by 56 · see citing works

Targeting regulatory T cells for immunotherapy in melanoma

Huang, L., Guo, Y., Liu, S., Wang, H., Zhu, J., Ou, L., & Xu, X. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00038-z · Cited by 56 · see citing works

Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function

Katsuyama, T., & Moulton, V. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109339 · Cited by 56 · see citing works

Estrogens, Cancer and Immunity

Orzołek, I., Sobieraj, J., & Domagala-Kulawik, J. J. (2022) · Cancers · doi:10.3390/cancers14092265 · Cited by 55 · see citing works

Comprehensive evaluation of the effects of long-term cryopreservation on peripheral blood mononuclear cells using flow cytometry

Li, B., Yang, C., Jia, G., Liu, Y., Wang, N., Yang, F., Su, R. J., Shang, Y., & Han, Y. (2022) · BMC Immunology · doi:10.1186/s12865-022-00505-4 · Cited by 55 · see citing works

Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers

Oparaugo, N. C., Ouyang, K., Nguyen, N. P. N., Nelson, A. M., & Agak, G. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021527 · Cited by 60 · see citing works

Kidney GATA3+ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

Sakai, R., Ito, M., Komai, K., Iizuka-Koga, M., Matsuo, K., Nakayama, T., Yoshie, O., Amano, K., Nishimasu, H., Nureki, O., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00547-x · Cited by 55 · see citing works

l -Arabinose Attenuates Gliadin-Induced Food Allergy via Regulation of Th1/Th2 Balance and Upregulation of Regulatory T Cells in Mice

Wang, Y., Sun, J., Xue, L., Liu, J., Nie, C., Fan, M., Qian, H., Zhang, D., Ying, H., Li, Y., et al. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07167 · Cited by 54 · see citing works

Human FOXP 3+ T regulatory cell heterogeneity

Mohr, A., Malhotra, R., Mayer, G., Gorochov, G., & Miyara, M. (2018) · Clinical & Translational Immunology · doi:10.1002/cti2.1005 · Cited by 88 · see citing works

Defining Human Regulatory T Cells beyond FOXP3: The Need to Combine Phenotype with Function

Gootjes, C., Zwaginga, J. J., Roep, B. O., & Nikolić, T. (2024) · Cells · doi:10.3390/cells13110941 · Cited by 48 · see citing works

The role of gp130-related cytokines in the modulation of human regulatory T cell function

Bartolucci, S. (2019) · doi:10.82308/7148

FOXP3+ regulatory T cells and their functional regulation

Li, Z., Li, D., Tsun, A., & Li, B. (2015) · Cellular &amp; Molecular Immunology · doi:10.1038/cmi.2015.10 · Cited by 290 · see citing works

The role of FOXP3+ regulatory T cells in human autoimmune and inflammatory diseases

Mohr, A., Atif, M., BALDERAS, R. S., Gorochov, G., & Miyara, M. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13288 · Cited by 88 · see citing works