The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Circulating CD21 low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells
Open accessAbstract
The homeostasis of circulating B cell subsets in the peripheral blood of healthy adults is well regulated, but in disease it can be severely disturbed. Thus, a subgroup of patients with common variable immunodeficiency (CVID) presents with an extraordinary expansion of an unusual B cell population characterized by the low expression of CD21. CD21 low B cells are polyclonal, unmutated IgM + IgD + B cells but carry a highly distinct gene expression profile which differs from conventional naïve B cells. Interestingly, while clearly not representing a memory population, they do share several features with the recently defined memory-like tissue, Fc receptor-like 4 positive B cell population in the tonsils of healthy donors. CD21 low B cells show signs of previous activation and proliferation in vivo, while exhibiting defective calcium signaling and poor proliferation in response to B cell receptor stimulation. CD21 low B cells express decreased amounts of homeostatic but increased levels of inflammatory chemokine receptors. This might explain their preferential homing to peripheral tissues like the bronchoalveolar space of CVID or the synovium of rheumatoid arthritis patients. Therefore, as a result of the close resemblance to the gene expression profile, phenotype, function and preferential tissue homing of murine B1 B cells, we suggest that CD21 low B cells represent a human innate-like B cell population.
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Cites
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Cited by
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Metadata
- Authors
- Rakhmanov, M., Keller, B., Gutenberger, S., Foerster, C., Hoenig, M., Driessen, G., van der Burg, M., van Dongen, J. J., Wiech, E., Visentini, M., Quinti, I., Prasse, A., Voelxen, N., Salzer, U., Goldacker, S., Fisch, P., Eibel, H., Schwarz, K., Peter, H.-H., & Warnatz, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-08-11
- Volume
- 106
- Issue
- 32
- Pages
- 13451-13456
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971833928
- Cited by
- 333
- References
- 36
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rakhmanov, M., Keller, B., Gutenberger, S., Foerster, C., Hoenig, M., Driessen, G., van der Burg, M., van Dongen, J. J., Wiech, E., Visentini, M., Quinti, I., Prasse, A., Voelxen, N., Salzer, U., Goldacker, S., Fisch, P., Eibel, H., Schwarz, K., Peter, H.-H., & Warnatz, K. (2009). Circulating CD21 low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0901984106
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
