The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Peripheral development of B cells in mouse and man
Abstract
Summary: In man and in mouse, B‐cell maturation occurs in steps, first in the bone marrow from hematopoietic precursors to immature/transitional B cells, then in the periphery from transitional to fully mature B cells. Each developmental step is tightly controlled by the expression and function of the B‐cell receptor (BCR) and by the ability to interact with the microenvironment. Mature B cells collaborate with T cells in the adaptive immune response, leading to the production of high‐affinity antibodies. This response is very accurate, but slow. Immediately after pathogen entry, however, antibodies already present in the serum reinforce the innate immune response and contribute to the first‐line defense against infection. Low‐affinity natural antibodies are produced by B‐1a B cells in the mouse and immunoglobulin M (IgM) memory cells in man. These antibodies represent an immediate protection against all microorganisms and the only one against encapsulated bacteria. B‐1a and IgM memory B cells may function as a link between the innate and adaptive immune response and thus perform a primordial B‐cell function.
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1 retracted
RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
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RetractedChromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
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Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations
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Cited by
Blair, P. A., Noreña, L. Y., Flores-Borja, F., Rawlings, D. J., Isenberg, D. A., Ehrenstein, M. R., & Mauri, C. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.009 · Cited by 1,574
The generation of antibody-secreting plasma cells
Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3795 · Cited by 1,454
The double life of a B-1 cell: self-reactivity selects for protective effector functions
Baumgarth, N. (2011) · Nature Reviews Immunology · doi:10.1038/nri2901 · Cited by 969
Flores-Borja, F., Bosma, A., Ng, D., Reddy, V., Ehrenstein, M. R., Isenberg, D. A., & Mauri, C. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005407 · Cited by 688
Leandro, M. J., Cambridge, G., Ehrenstein, M. R., & Edwards, J. C. W. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21617 · Cited by 560
Metadata
- Authors
- Carsetti, R., Rosado, M. M., & Wardmann, H.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-01-06
- Volume
- 197
- Issue
- 1
- Pages
- 179-191
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W1979640049
- Cited by
- 473
- References
- 60
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
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