The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development
Open accessAbstract
The molecular mechanism by which neural progenitor cells commit to a specified lineage of the central nervous system remains unknown. We show that HDAC1 and HDAC2 redundantly control neuronal development and are required for neuronal specification. Mice lacking HDAC1 or HDAC2 in neuronal precursors show no overt histoarchitectural phenotypes, whereas deletion of both HDAC1 and HDAC2 in developing neurons results in severe hippocampal abnormalities, absence of cerebellar foliation, disorganization of cortical neurons, and lethality by postnatal day 7. These abnormalities in brain formation can be attributed to a failure of neuronal precursors to differentiate into mature neurons and to excessive cell death. These results reveal redundant and essential roles for HDAC1 and HDAC2 in the progression of neuronal precursors to mature neurons in vivo.
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Cites
Chromatin modifications and their function
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CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION
Hatten, M. E. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.511 · Cited by 797
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
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Self-citationHistone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
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Self-citationTherapeutic application of histone deacetylase inhibitors for central nervous system disorders
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Cited by
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
Falkenberg, K. J., & Johnstone, R. W. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4360 · Cited by 1,564
Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., & Rumbaugh, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.197 · Cited by 727
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
Epigenetic control of neural precursor cell fate during development
Hirabayashi, Y., & Gotoh, Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2810 · Cited by 375
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Pietrosanti, L., De Smaele, E., Ferretti, E., Miele, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2013 · Cited by 322
Metadata
- Authors
- Montgomery, R. L., Hsieh, J., Barbosa, A. C., Richardson, J. A., & Olson, E. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2009-05-12
- Volume
- 106
- Issue
- 19
- Pages
- 7876-7881
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969386224
- Cited by
- 306
- References
- 31
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Montgomery, R. L., Hsieh, J., Barbosa, A. C., Richardson, J. A., & Olson, E. N. (2009). Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0902750106
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
