The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
Open accessAbstract
CD39/ENTPD1 hydrolyzes proinflammatory nucleotides to generate adenosine. As purinergic mediators have been implicated in intestinal inflammation, we hypothesized that CD39 might protect against inflammatory bowel disease. We studied these possibilities in a mouse model of colitis using mice with global CD39 deletion. We then tested whether human genetic polymorphisms in the CD39 gene might influence susceptibility to Crohn's disease. We induced colitis in mice using Dextran Sodium Sulfate (DSS). Readouts included disease activity scores, histological evidence of injury, and markers of inflammatory activity. We used HapMap cell lines to find SNPs that tag for CD39 expression, and then compared the frequency of subjects with high vs. low CD39-expression genotypes in a case-control cohort for Crohn's disease. Mice null for CD39 were highly susceptible to DSS injury, with heterozygote mice showing an intermediate phenotype compared to wild type (WT). We identified a common SNP that tags CD39 mRNA expression levels in man. The SNP tagging low levels of CD39 expression was associated with increased susceptibility to Crohn's disease in a case-control cohort comprised of 1,748 Crohn's patients and 2,936 controls ( P = 0.005–0.0006). Our data indicate that CD39 deficiency exacerbates murine colitis and suggest that CD39 polymorphisms are associated with inflammatory bowel disease in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with these in vitro observations, individuals with reduced ability to transcribe CD39 due to a promoter polymorphism (Friedman et al., 2009) have better responses to TIV as well as VZV vaccination”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Friedman et al., 2009
In the citing paper
“In humans, polymorphisms of ENTPD1 were shown to be associated with IBD, and expression of P2X7 was increased in the intestinal epithelium and lamina propria of IBD patients (Friedman et al., 2009; Neves et al., 2014).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Friedman et al., 2009
In the citing paper
“Entpd1−/− mice, which cannot remove extracellular ATP through this mechanism, where highly susceptible to experimental colitis (Friedman et al., 2009).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Friedman et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,613
Self-citationPopulation genomics of human gene expression
Stranger, B. E., Nica, A. C., Forrest, M. S., Dimas, A. S., Bird, C., Beazley, C., Ingle, C., Dunning, M., Flicek, P., Koller, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2142 · Cited by 1,153
ATP drives lamina propria TH17 cell differentiation
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089
A genome-wide association study of global gene expression
Dixon, A. L., Liang, L., Moffatt, M. F., Chen, W., Heath, S. C., Wong, K., Taylor, J. C., Burnett, E. C., Gut, I. G., Farrall, M., et al. (2007) · Nature Genetics · doi:10.1038/ng2109 · Cited by 946
The genetics and immunopathogenesis of inflammatory bowel disease
Cho, J. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2340 · Cited by 940
Robson, S. C., Sévigny, J., & Zimmermann, H. (2006) · Purinergic Signalling · doi:10.1007/s11302-006-9003-5 · Cited by 930
Self-citationTysk, C., Lindberg, E. H., Järnerot, G., & FLODERUS-MYRHED, B. (1988) · Gut · doi:10.1136/gut.29.7.990 · Cited by 828
Research works printed but not linked: 1
- 10.2337/db07-1265 · DOI
Cited by
Sorted by citations
Items 201–284 of 284
E4BP4 in macrophages induces an anti-inflammatory phenotype that ameliorates the severity of colitis
Kajimura, Y., Taguchi, A., Nagao, Y., Yamamoto, K., Masuda, K., Shibata, K., Asaoka, Y., Furutani-Seiki, M., Tanizawa, Y., & Ohta, Y. (2024) · Communications Biology · doi:10.1038/s42003-024-06099-4 · Cited by 14
Wu, X., Chen, P.-I., Whitener, R. L., MacDougall, M. S., Coykendall, V. M. N., Yan, H., Kim, Y. B., Harper, W., Pathak, S., Iliopoulou, B. P., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1415102 · Cited by 15
Kruse, R. L., Demirel, I., Säve, S., & Persson, K. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9414-7 · Cited by 13
The impact of intestinal resection on the immune function of short bowel syndrome patients
Turato, W. M., Sales‐Campos, H., Braga, C. B. M., da Cunha, S. F. D. C., Silvah, J. H., da Silva, J. S., Marchini, J. S., & Cardoso, C. R. D. B. (2016) · Human Immunology · doi:10.1016/j.humimm.2016.07.237 · Cited by 13
Targeting ectonucleotidases to treat inflammation and halt cancer development in the gut
Longhi, M. S., Feng, L., & Robson, S. C. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114417 · Cited by 13
Self-citationUpregulation of miR‐9 and miR‐193b over human Th17 cell differentiation
Shirani, F., Baghi, M., Delavar, M. R., Nejati, A. S., Eshaghiyan, A., Nasr‐Esfahani, M. H., Peymani, M., & Ghaedi, K. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1538 · Cited by 12
CD39+ regulatory T cells modulate the immune response to carbamazepine in HLA-B*15:02 carriers
Shen, M., Lim, J. M. E., Chia, C., & Ren, E. C. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.003 · Cited by 12
Kasinathan, N. K., Raja, S. B., Pandian, I., & Sivasithamparam, N. D. (2014) · Biomedicine & Preventive Nutrition · doi:10.1016/j.bionut.2014.03.002 · Cited by 11
Adhikary, S. R., Cuthbertson, P., Turner, R. J., Sluyter, R., & Watson, D. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12328 · Cited by 11
Research progress of P2X7 receptor in inflammatory bowel disease
Liu, Y., & Liu, X. (2019) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2019.1609077 · Cited by 11
Nemoto, E., Gotoh, K., Tsuchiya, M., Sakisaka, Y., & Shimauchi, H. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.07.014 · Cited by 11
Almutary, A. G., Alnuqaydan, A. M., Almatroodi, S. A., & Tambuwala, M. M. (2023) · Applied Sciences · doi:10.3390/app13053233 · Cited by 10
Novel therapeutic concepts for inflammatory bowel disease—from bench to bedside
Neudecker, V., Colgan, S. P., & Eltzschig, H. K. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1574-9 · Cited by 10
CD39 pathway inhibits Th1 cell function in tuberculosis
Luo, Y., Xue, Y., Lin, Q., Tang, G., Song, H., Liu, W., Mao, L., Ziyong, S., & Wang, F. (2022) · Immunology · doi:10.1111/imm.13493 · Cited by 8
Li, L., Zhang, X., Li, W., Gao, M., Wang, Y., Zhang, Z., Yang, X., & Yang, J. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13547 · Cited by 9
Calame, D. G., Herman, I., Maroofian, R., Marshall, A. E., Donis, K. C., Fatih, J. M., Mitani, T., Du, H., Grochowski, C. M., de Sousa, S. B., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26381 · Cited by 9
Self-citationHuang, L., Fan, J., Chen, Y., & Wang, J.-H. (2020) · Mediators of Inflammation · doi:10.1155/2020/1562973 · Cited by 9
Hendrawan, K., Visweswaran, M., Ma, D. D. F., & Moore, J. J. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0710-2 · Cited by 9
Kim, H., Kim, B., Lee, M.-R., Ra, M., & Lee, Y. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44100345 · Cited by 8
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
Fonseca‐Camarillo, G., Furuzawa‐Carballeda, J., Miguel-Cruz, E., Barreto‐Zúñiga, R., Martínez‐Benítez, B., & Yamamoto-Furusho, J. K. (2025) · Immunologic Research · doi:10.1007/s12026-024-09583-5 · Cited by 8
Adenosine, Schizophrenia and Cancer: Does the Purinergic System Offer a Pathway to Treatment?
Hamoud, A.-R. A., Bach, K., Kakrecha, O., Henkel, N., Wu, X., McCullumsmith, R. E., & O'Donovan, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911835 · Cited by 8
Ectonucleotidases in Solid Organ and Allogeneic Hematopoietic Cell Transplantation
Chernogorova, P., & Zeiser, R. (2012) · BioMed Research International · doi:10.1155/2012/208204 · Cited by 8
Maloney, J. P., Branchford, B. R., Brodsky, G. L., Cosmic, M. S., Calabrese, D. W., Aquilante, C. L., Maloney, K. W., González, J. R., Zhang, W., Moreau, K. L., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201600344r · Cited by 8
Hanidziar, D., & Robson, S. C. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00406.2020 · Cited by 8
Self-citationAnti-Oxidative Stress and Beyond: Multiple Functions of the Protein Glutathionylation
Hu, Y., Wang, T., Liao, X., Du, G., Chen, J., & Xu, J. (2010) · Protein and Peptide Letters · doi:10.2174/092986610792231573 · Cited by 8
Distribution of P2Y and P2X purinergic receptor expression within the intestine
Engevik, K. A., Scribano, F. J., Gebert, J. T., Perry, J. L., Crawford, S. E., & Hyser, J. M. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00108.2023 · Cited by 8
Picozza, M., Cristofoletti, C., Bresin, A., Fioretti, M., Sambucci, M., Scala, E., Monopoli, A., Cantonetti, M., Pilla, M. A., Accetturi, M. P., et al. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.04.017 · Cited by 7
Kabel, A. M., Atef, A., Borg, H. M., El‐Sheikh, A. A. K., Khabbaz, H. J. A., Arab, H. H., & Estfanous, R. S. (2022) · Pharmaceuticals · doi:10.3390/ph15050600 · Cited by 7
Antisense to human CD39 dysregulates immune metabolism in inflammatory bowel disease
Zhang, L., Cagle, C., Nguyen, D. H., Gomes, G. S., Gromová, B., Csizmadia, E., Karimitar, A., Lee, G. R., Chen, G., Kokkotou, E. G., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01295-6 · Cited by 6
Self-citationThe transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
Nelius, E., Fan, Z., Sobecki, M., Krzywińska, E., Nagarajan, S., Ferapontova, I., Gotthardt, D., Takeda, N., Sexl, V., & Stockmann, C. (2024) · Life Science Alliance · doi:10.26508/lsa.202402593 · Cited by 6
Duan, K., Wang, T., You, J., Wang, H., Wang, Z., Huang, Z., Zhang, J., Sun, Y., Xiong, Y., Guan, K., et al. (2024) · Immunology · doi:10.1111/imm.13827 · Cited by 6
Lee, A., Chung, Y. C., Song, K. H., Ryuk, J. A., Ha, H., & Hwang, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116534 · Cited by 6
Autoimmune Hepatitis: Clinical Review with Insights into the Purinergic Mechanism of Disease
Kapila, N., Higa, J. T., Longhi, M. S., & Robson, S. C. (2013) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2013.00015 · Cited by 6
Self-citationZhang, X., Chen, X., Bai, T., Meng, X., Wu, Y., Yang, A., Min, L., Chen, H., & Li, X. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12844 · Cited by 5
Lin, M., Yang, Y., Lin, L., Yu, W., & Chen, H. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-022-03696-w · Cited by 5
Adenosine Metabolism Pathway Alterations in Frontal Cortical Neurons in Schizophrenia
Sahay, S., Devine, E. A., Vargas, C. F.-A., McCullumsmith, R. E., & O'Donovan, S. M. (2024) · Cells · doi:10.3390/cells13191657 · Cited by 5
Interferon-γ sensing by epithelial cells tames gut inflammation
Pabst, O., & Cerovic, V. (2024) · Nature Immunology · doi:10.1038/s41590-023-01705-9 · Cited by 5
Bhalla, M., Simmons, S. R., Lenhard, A. P., Betadpur, A., Battaglia, M. C., & Ghanem, E. N. B. (2025) · mSphere · doi:10.1128/msphere.00640-23 · Cited by 6
Cristofoletti, C., Bresin, A., Fioretti, M., Russo, G., & Narducci, M. G. (2022) · Cancers · doi:10.3390/cancers14122847 · Cited by 4
Neumann, S., Peyroux, E. M., Woodall, M. J., Shields, N. J., Young, S. L., & Pattison, S. T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88137 · Cited by 4
Antiplatelet agents’-ticagrelol and eptifibatide-safety in experimental colitis in mice
Petrović, S., Vasiljevska, M., Obradovic, S. D., Tarabar, D. K., Doder, R., Majstorović, I., Petrović, M., Magić, Z., Cikota‐Aleksić, B., Perisic, N., et al. (2020) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2020.19454 · Cited by 4
Ectonucleotidases in Cancer and Inflammation
Stagg, J., Thompson, L. F., & Dwyer, K. M. (2012) · BioMed Research International · doi:10.1155/2012/951423 · Cited by 4
Son, S. J., Han, A.-R., Sung, M. J., Hong, S. M., & Lee, S. (2023) · Antioxidants · doi:10.3390/antiox12101822 · Cited by 4
Ye, H., He, Y., Jin, M., Ye, Z., Huang, Q., Chen, H., & Ye, M. (2025) · Food Quality and Safety · doi:10.1093/fqsafe/fyaf014 · Cited by 3
Sakthivel, K. M., Rasmi, R. R., Dharshini, L. C. P., Kumar, K. M., Prabhu, V. V., & Ramesh, B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151973 · Cited by 3
Martín‐Reyes, F., Bousellam, I. K., Ruiz‐Malagón, A. J., Ho‐Plagaro, A., Gomez, C. L., Herraiz-Vilela, M., Alcaín‐Martínez, G., Camargo, R., Dussen, J. V. M. V., Martel, L. C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-07147-7 · Cited by 3
Physiological and Pathological Inflammation at the Mucosal Frontline
Kurashima, Y., & Kiyono, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-56068-5_43 · Cited by 3
Grant, C. R., Liberal, R., Ma, Y., Robson, S. C., Mieli‐Vergani, G., Vergani, D., & Longhi, M. S. (2014) · Hepatology · doi:10.1002/hep.27309 · Cited by 3
Self-citationGan, C., Wu, Q. V., Goronzy, J. J., Zhang, Y., Li, L., Sheng, H., & Fang, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1679064 · Cited by 2
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
Tsai, A. K., & Stromnes, I. M. (2023) · Gut · doi:10.1136/gutjnl-2023-330424 · Cited by 3
Causal role of immune cells in inflammatory bowel disease: A Mendelian randomization study
Chen, H., Li, Q., Gao, T., Wang, Y., Ren, X., Liu, S., Zhang, S., Zhou, P., Lyu, J., Bai, H., et al. (2024) · Medicine · doi:10.1097/md.0000000000037537 · Cited by 2
Kaur, P., Karuppuchamy, T., Chilukuri, A., Kim, M., Urrete, J., Shen, Z., Saxon, L., Lundborg, L. R., Mikulski, Z., Jedlicka, P., et al. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf030 · Cited by 1
Adenosine-generating CD39+plasmablasts predispose to successful infliximab therapy in pediatric IBD
Schnell, A., Schwarz, B., Schmidt, H., Allabauer, I., Schuh, W., Regensburger, A. P., Rauh, M., Woelfle, J., & Hoerning, A. (2025) · Life Science Alliance · doi:10.26508/lsa.202403055 · Cited by 2
The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome
Ribeiro, B. E., de Lima, I. S., Souza, K. C. D. S. E., Rosas, S. L. B., Santana, P. T., Amaral, G. R. S., Machado, J. C., de Oliveira, R. P., Leal, C. V., Thompson, C. C., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101718 · Cited by 1
Biswas, P., Mishra, V., Sanchez‐Garrido, J., & Frankel, G. M. (2026) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2026.101826 · Cited by 1
Enteric Glial Cells: Implications in Gut Pathology
Gulbransen, B. D., & Brown, I. A. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0974-2_21 · Cited by 1
Радыгина, Т. В., Петричук, С. В., Купцова, Д. Г., Потапов, А. С., Illarionov, A., Олегович, А. А., Курбатова, О. В., & Semikina, E. L. (2022) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2022.039 · Cited by 1
Purinergic Signaling in Neutrophils During Inflammatory DiseasesPreprint
Sun, H., Xu, G., Li, P., Li, Y., & Sun, B. (2020) · Preprints.org · doi:10.20944/preprints202003.0185.v1
Sévigny, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_197 · Cited by 1
Regulation of immune responses by ATP-hydrolyzing ecto-enzymes
Takeda, K., Tsai, S. H., & Kayama, H. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.172
Research Highlight Purinergic Control of Neutrophil Activation
Grassi, F. (2016)
Review Article Regulation of innate immunity by extracellular nucleotides
Gorini, S., Gatta, L., Pontecorvo, L., Vitiello, L., Sala, A., & Raffaele, S. (2013)
Peres, R. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-06012017-163133
Rahimzadeh, M., & Pirdel, L. (2018) · مجله دانشگاه علوم پزشکی اردبیل · doi:10.29252/jarums.18.1.108
Thude, H., Onken, L., Kappauf, J., Dworak, M., Sterneck, M. R., Peine, S., Nashan, B., & Koch, M. (2020) · HLA · doi:10.1111/tan.13892
Activation of Purinergic Signaling Pathways during the Development of Inflammatory Bowel Disease
Zherebiatiev, O., Voitovich, O. V., Motilonok, T. Y., Egorov, A. A., & Burega, I. Y. (2020) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs05.06.017
The Role of CD39 in Modulating Effector Immune Responses in Inflammatory Bowel Disease
Citation, H. (2016) · Cited by 1
Kajimura, Y., Taguchi, A., Ohta, Y., Yamamoto, K., Masuda, K., Shibata, K., Furutani‐Seiki, M., & Tanizawa, Y. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3981898
Sévigny, J. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_197
Sévigny, J. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_197-1
Leite-Aguiar, R., Giorgi, M. D., Savio, L. E. B., & Robson, S. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00158-7
Self-citationNishikawa, M., Miyagi, R., Kugimiya, Y., Chudan, S., Furusawa, Y., & Ikushiro, S. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70135
Content of T lymphocytes expressing ectonucleotidases CD39 and СD73 in ulcerative colitis
Жулай, Г. А., Topchieva, L. V., Алексеевич, А. Д., Дуданова, О. П., & Валерьевна, К. И. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-231-11-81-89
The influence of biologic therapy on the capacity of regulatory T cells to restrain Th17 responses
McGovern, J. L. (2012) · UCL Discovery (University College London)
Extracellular ATP signaling in gastrointestinal disorders
Weng, Z., Jiang, L., & Liu, H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30250-3.00030-8
Son, S. J., Han, A., Sung, M. J., Na, H., Hong, S. M., & Lee, S. H. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71763
花岡(池田), 有., Tsuboi, Y., Kasai, Y., Masuda, T., Ichihara, H., Watanabe, S., Shinozaki, M., Ohta, Y., Matsubara, D., & Murakami, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093908
Mavropoulos, Α., Tsiogkas, S. G., Simopoulou, T., Dardiotis, E., Zafiriou, E., Sakkas, L. I., & Bogdanos, D. P. (2026) · Rheumatology International · doi:10.1007/s00296-026-06114-3
Hu, Z., Liu, M., Zhu, C., Li, N., Chen, X., Da, B., Li, Y., & Yu, C. (2026) · Inflammation Research · doi:10.1007/s00011-026-02332-4
Valdez-Moráles, E. E., Liñán-Rico, A., & Alba, R. G. (2026) · Frontiers in Gastroenterology · doi:10.3389/fgstr.2026.1954794
Bunk, P., Ergin, I., Maher, T., Shah, V., Bonney, J. R., Kumar, L. B. S. S., Chung, C., Wellhausen, N., Moresco, P., Shao, S., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02685-2
BindingDB Entry 50020705: Discovery of Selective P2Y
BindingDB (2024) · UC San Diego · doi:10.7270/q2rr23qf
Metadata
- Authors
- Friedman, D. J., Künzli, B. M., A-Rahim, Y. I., Sevigny, J., Berberat, P. O., Enjyoji, K., Csizmadia, E., Friess, H., & Robson, S. C.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of Hawaiʻi at Mānoa (US)
- Transplantation Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard University, 330 Brookline Avenue, Boston, MA 02215;
- Technical University of Munich (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-09-29
- Volume
- 106
- Issue
- 39
- Pages
- 16788-16793
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2757811
- OpenAlex
- W2163178183
- Cited by
- 284
- References
- 40
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 12 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 25 · 2019: 23 · 2018: 15 · 2017: 20 · 2016: 18 · 2015: 20 · 2014: 20 · 2013: 15 · 2012: 21
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Wellcome Trust
- National Institutes of Health (5p01hl076540-10)
- National Heart, Lung, and Blood Institute (HL-57307, HL63972, HL 076540, R01HL094400, P01 HL-076540, R01HL057307, R01HL063972)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK076868)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- CD39, adenosine, purinergic signaling, inflammatory bowel disease, Crohn's disease, colitis, DSS-induced colitis, genetic polymorphism, single nucleotide polymorphisms, genetic susceptibility, nucleotide hydrolysis
- MeSH terms
- Animals, Apyrase, Colitis, Crohn Disease, Disease Models, Animal, Genotype, Humans, Mice, Inbred C57BL, Polymorphism, Genetic, RNA, Messenger, Inflammatory Bowel Diseases, Antigens, CD, Sequence Deletion, Genetic Predisposition to Disease, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
