The genetics and immunopathogenesis of inflammatory bowel disease

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591 · see citing works

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

A second generation human haplotype map of over 3.1 million SNPs

The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., & Podolsky, D. K. (2007) · Nature · doi:10.1038/nature06005 · Cited by 4,364 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

Inflammatory Bowel Disease

Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183 · see citing works

Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences

Loftus, E. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.063 · Cited by 3,115 · see citing works

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087 · see citing works

A Genome-Wide Association Study Identifies <i>IL23R</i> as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039 · see citing works

Genome-wide association studies for common diseases and complex traits

Hirschhorn, J. N., & Daly, M. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1521 · Cited by 2,853 · see citing works

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

the NIDDK IBD Genetics Consortium, Barrett, J. C., the Belgian-French IBD Consortium, the Wellcome Trust Case Control Consortium, Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., et al. (2008) · Nature Genetics · doi:10.1038/ng.175 · Cited by 2,593 · see citing works

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Zhou, L., Ivanov, I. I., Spolski, R. J., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., & Littman, D. R. (2007) · Nature Immunology · doi:10.1038/ni1488 · Cited by 2,134 · see citing works

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Gabriele Mayr, B., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,899 · see citing works

Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746 · see citing works

Increased expression of interleukin 17 in inflammatory bowel disease

Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713 · see citing works

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200673200 · Cited by 1,694 · see citing works

High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease

Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566 · see citing works

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

Yen, D., Cheung, J., Scheerens, H., Poulet, F. M., McClanahan, T. K., McKenzie, B. S., Kleinschek, M. A., Owyang, A. M., Mattson, J. D., Blumenschein, W. M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,532 · see citing works

Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507 · see citing works

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329 · see citing works

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12Rβ1 and a Novel Cytokine Receptor Subunit, IL-23R

Parham, C. L., Chirica, M., Timans, J., Vaisberg, E., Travis, M. A., Cheung, J., Pflanz, S., Zhang, R. V., Singh, K. P., Vega, F., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5699 · Cited by 1,297 · see citing works

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5

Fuss, I. J., Neurath, M. F., Boirivant, M., Klein, J. S., de la Motte, C., Strong, S. A., Fiocchi, C., & Strober, W. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1261 · Cited by 1,227 · see citing works

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220 · see citing works

Genome-wide association studies: theoretical and practical concerns

Wang, W. Y. S., Barratt, B. J., Clayton, D. G., & Todd, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1522 · Cited by 1,159 · see citing works

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,144 · see citing works

A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes

Cargill, M., Schrodi, S. J., Chang, M., Garcia, V. E., Brandon, R., Callis, K. P., Matsunami, N., Ardlie, K. G., Civello, D., Catanese, J. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/511051 · Cited by 1,086 · see citing works

STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

Remmers, E. F., Plenge, R. M., Lee, A. T., Graham, R., Hom, G., Behrens, T. W., de Bakker, P. I. W., Le, J. M., Lee, H., Batliwalla, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa073003 · Cited by 1,040 · see citing works

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A. K., Blumberg, R. S., Xavier, R. J., & Mizoguchi, A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33194 · Cited by 1,016 · see citing works

Reduced Paneth cell α-defensins in ileal Crohn's disease

Wehkamp, J., Salzman, N. H., Porter, E. M., Nuding, S., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M. G., Linzmeier, R. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505256102 · Cited by 988 · see citing works

Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria

Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006) · Science · doi:10.1126/science.1129577 · Cited by 915 · see citing works

Unveiling the roles of autophagy in innate and adaptive immunity

Levine, B., & Deretic, V. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2161 · Cited by 903 · see citing works

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Mannon, P., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D. H., Dolin, B. J., Goodman, N., Groden, C. A., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 844 · see citing works

Functional variants of OCTN cation transporter genes are associated with Crohn disease

Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, W. G., Oene, M. V., Cescon, D. W., Greenberg, G. R., et al. (2004) · Nature Genetics · doi:10.1038/ng1339 · Cited by 837 · see citing works

Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.

Tysk, C., Lindberg, E. H., Järnerot, G., & FLODERUS-MYRHED, B. (1988) · Gut · doi:10.1136/gut.29.7.990 · Cited by 828 · see citing works

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823 · see citing works

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791 · see citing works

Activation of nuclear factor κB in inflammatory bowel disease

Schreiber, S., Nikolaus, S., & Hampe, J. (1998) · Gut · doi:10.1136/gut.42.4.477 · Cited by 752 · see citing works

Peptidoglycan Molecular Requirements Allowing Detection by Nod1 and Nod2

Girardin, S. E., Travassos, L. H., Hervé, M., Blanot, D., Boneca, I. G., Philpott, D. J., Sansonetti, P. J., & Mengin‐Lecreulx, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307198200 · Cited by 684 · see citing works

Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology

Uhlig, H. H., McKenzie, B. S., Hüe, S., Thompson, C., Joyce-Shaikh, B., Štëpánková, R., Robinson, N., Buonocore, S. M., Tlaskalová‐Hogenová, H., Cua, D. J., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.017 · Cited by 681 · see citing works

Epidemiology of Crohn's Disease and Ulcerative Colitis in a Central Canadian Province: A Population-based Study

Bernstein, C. N., Blanchard, J., Rawsthorne, P. E., & Wajda, A. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009735 · Cited by 661 · see citing works

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632 · see citing works

Crohn's disease in Olmsted County, Minnesota, 1940–1993: Incidence, prevalence, and survival

Loftus, E. V., Silverstein, M. D., Sandborn, W. J., Tremaine, W. J., Harmsen, W. S., & Zinsmeister, A. R. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70421-4 · Cited by 623 · see citing works

IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis

Kullberg, M. C., Jankovic, D. L., Feng, C. G., Hüe, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F. M., Cheever, A. W., Maloy, K. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061082 · Cited by 584 · see citing works

Signaling by IL‐12 and IL‐23 and the immunoregulatory roles of STAT4

Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L. M., & O’Shea, J. J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00211.x · Cited by 570 · see citing works

Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4

Libioulle, C., Louis, E. J., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D. P., Vermeire, S., Dewit, O., Vos, M. D., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 561 · see citing works

The Genetics of Inflammatory Bowel Disease

Cho, J. H., & Weaver, C. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.032 · Cited by 550 · see citing works

Inflammatory Bowel Disease

Podolsky, D. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110033251406 · Cited by 537 · see citing works

Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival

Loftus, E. V., Silverstein, M. D., Sandborn, W. J., Tremaine, W. J., Harmsen, W. S., & Zinsmeister, A. R. (2000) · Gut · doi:10.1136/gut.46.3.336 · Cited by 492 · see citing works

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works

Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis

Economou, M., Trikalinos, T. A., Loizou, K. T., Tsianos, E. V., & Ioannidis, J. P. A. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40304.x · Cited by 464 · see citing works

Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice

Elson, C. O., Cong, Y., Weaver, C. T., Schoeb, T. R., McClanahan, T. K., Fick, R. B., & Kastelein, R. A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.104 · Cited by 453 · see citing works

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14459 · Cited by 443 · see citing works

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Lowe, C. E., Cooper, J. D., Brusko, T. M., Walker, N. M., Smyth, D. J., Bailey, R., Bourget, K., Plagnol, V., Field, S., Atkinson, M. A., et al. (2007) · Nature Genetics · doi:10.1038/ng2102 · Cited by 427 · see citing works

Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics

Halfvarson, J., Bodin, L., Tysk, C., Lindberg, E., & Järnerot, G. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00385-8 · Cited by 427 · see citing works

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D. C. O., Berzuini, C., Johnson, C., et al. (2008) · Nature Genetics · doi:10.1038/ng.145 · Cited by 424 · see citing works

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut

Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214459 · Cited by 418 · see citing works

Concordance of Inflammatory Bowel Disease among Danish Twins: Results of a Nationwide Study

Orholm, V. B. M. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200451207 · Cited by 406 · see citing works

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn’s disease

Plevy, S. E., Landers, C. J., Prehn, J., Carramanzana, N., Deem, R. L., Shealy, D. J., & Targan, S. R. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.12.6276 · Cited by 379 · see citing works

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

Franke, A., Balschun, T. C., Karlsen, T. H., Hedderich, J., May, S., Lu, T. T., Schuldt, D., Nikolaus, S., Rosenstiel, P. C., Krawczak, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.148 · Cited by 352 · see citing works

Inflammatory bowel disease and domestic hygiene in infancy

Gent, A. E., Hellier, M. D., Grace, R. H., Swarbrick, E. T., & Coggon, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91841-4 · Cited by 351 · see citing works

Genetics versus environment in inflammatory bowel disease: results of a British twin study

Thompson, N. P., Driscoll, R., Pounder, R. E., & Wakefield, A. J. (1996) · BMJ · doi:10.1136/bmj.312.7023.95 · Cited by 335 · see citing works

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis

Watanabe, T., Asano, N., Murray, P. J., Ozato, K., Tailor, P. B., Fuss, I. J., Kitani, A., & Strober, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33145 · Cited by 326 · see citing works

Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

Collazo, C. M., Yap, G. S., Sempowski, G. D., Lusby, K. C., Tessarollo, L., Woude, G. F. V., Sher, A., & Taylor, G. A. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.181 · Cited by 325 · see citing works

Both IL-12p70 and IL-23 are synthesized during active Crohnʼs disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

Fuss, I. J., Becker, C., Yang, Z., Groden, C. A., Hornung, R. L., Heller, F., Neurath, M. F., Strober, W., & Mannon, P. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000194183.92671.b6 · Cited by 322 · see citing works

Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death

Wiekowski, M., Leach, M. W., Evans, E. W., Sullivan, L., Chen, S., Vassileva, G., Bazán, J. F., Gorman, D. M., Kastelein, R. A., Narula, S. K., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7563 · Cited by 294 · see citing works

Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease

Yamazaki, K., Takazoe, M., Tanaka, T., Kazumori, T., & Nakamura, Y. (2002) · Journal of Human Genetics · doi:10.1007/s100380200067 · Cited by 291 · see citing works

The Cytosolic Sensors Nod1 and Nod2 Are Critical for Bacterial Recognition and Host Defense after Exposure to Toll-like Receptor Ligands

Kim, Y., Park, J., Shaw, M. H., Franchi, L., Inohara, N., & Núñez, G. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.012 · Cited by 280 · see citing works

Expression of Interleukin-12-Related Cytokine Transcripts in Inflammatory Bowel Disease: Elevated Interleukin-23p19 and Interleukin-27p28 in Crohnʼs Disease But Not in Ulcerative Colitis

Schmidt, C., Giese, T., Ludwig, B., Mueller-Molaian, I., Marth, T., Zeuzem, S., Meuer, S. C., & Stallmach, A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200501000-00003 · Cited by 279 · see citing works

IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease

Wolk, K., Witte, E., Hoffmann, U., Doecke, W., Endesfelder, S., Asadullah, K., Sterry, W., Volk, H., Wittig, B. M., & Sabat, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5973 · Cited by 269 · see citing works

Chronic stimulation of Nod2 mediates tolerance to bacterial products

Hedl, M., Li, J., Cho, J. H., & Abraham, C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706097104 · Cited by 269 · see citing works

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

Pauleau, A., & Murray, P. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7531-7539.2003 · Cited by 261 · see citing works

Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease

Simms, L. A., Doecke, J. D., Walsh, M., Huang, N., Fowler, E. V., & Radford‐Smith, G. L. (2008) · Gut · doi:10.1136/gut.2007.142588 · Cited by 243 · see citing works

Risk of Ulcerative Colitis among Former and Current Cigarette Smokers

Boyko, E. J., Koepsell, T. D., Perera, D. R., & Inui, T. S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198703193161202 · Cited by 230 · see citing works

Inflammatory Bowel Disease: From Bench to Bedside

(2003) · Springer eBooks · doi:10.1007/978-1-4020-3477-0 · Cited by 227 · see citing works

Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations

Croucher, P. J. P., Mascheretti, S., Hampe, J., Huse, K., Frenzel, H., Stoll, M., Lu, T. T., Nikolaus, S., Yang, S., Krawczak, M., et al. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200897 · Cited by 226 · see citing works

NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population

Leong, R. W. L., Armuzzi, A., Ahmad, T., Wong, M. L., Tse, P., Jewell, D. P., & Sung, J. J. �. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01607.x · Cited by 226 · see citing works

Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis

Becker, C., Dornhoff, H., Neufert, C. F., Fantini, M. C., Wirtz, S. J., Huebner, S., Nikolaev, A., Lehr, H., Murphy, A. J., Valenzuela, D. M., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2760 · Cited by 225 · see citing works

Prevalence of CARD15/NOD2 Mutations in Caucasian Healthy People

Hugot, J., Zaccaria, I., Cavanaugh, J. A., Yang, H., Vermeire, S., Lappalainen, M., Schreiber, S., Annese, V., Jewell, D. P., Fowler, E. V., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01149.x · Cited by 200 · see citing works

Functional consequences of NOD2 (CARD15) mutations

Abraham, C., & Cho, J. H. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000225332.83861.5f · Cited by 130 · see citing works

Autophagy in Innate Immunity against Intracellular Bacteria

Amano, A., Nakagawa, I., & Yoshimori, T. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj162 · Cited by 129 · see citing works

Genetic Epidemiology in Inflammatory Bowel Disease

Binder, V. (1998) · Digestive Diseases · doi:10.1159/000016891 · Cited by 124 · see citing works

Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn?s disease

Stallmach, A., Giese, T., Schmidt, C., Ludwig, B., Mueller-Molaian, I., & Meuer, S. C. (2004) · International Journal of Colorectal Disease · doi:10.1007/s00384-003-0554-4 · Cited by 111 · see citing works

Inflammatory Bowel Disease—From Bench to Bedside.

Kirsner, J. B. (1995) · Inflammatory Bowel Diseases · doi:10.1002/ibd.3780010317 · Cited by 105 · see citing works

Inflammatory Bowel Disease—From Bench to Bedside.

Kirsner, J. B. (1995) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199509000-00016 · Cited by 104 · see citing works

Comparative Phenotypic and CARD15 Mutational Analysis Among African American, Hispanic, and White Children with Crohnʼs Disease

Kugathasan, S., Loizides, A. M., Babusukumar, U., McGuire, E., Wang, T., Hooper, P., Nebel, J., Kofman, G., Noel, R. J., Broeckel, U., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000171279.05471.21 · Cited by 89 · see citing works

Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease

Silverberg, M. S., Duerr, R. H., Brant, S. R., Bromfield, G. P., Datta, L. W., Jani, N. D., Kane, S. V., Rotter, J. I., Schumm, L. P., Steinhart, A. H., et al. (2007) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201756 · Cited by 87 · see citing works

Inflammatory bowel disease in African-American children living in Georgia

Ogunbi, S. O., Ransom, J., Sullivan, K. M., Schoen, B. T., & Gold, B. D. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70187-8 · Cited by 85 · see citing works

Architectural Defects in the Spleens of Nkx2-3-Deficient Mice Are Intrinsic and Associated with Defects in Both B Cell Maturation and T Cell-Dependent Immune Responses

Tarlinton, D. M., Light, A., Metcalf, D., Harvey, R. P., & Robb, L. G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4002 · Cited by 45 · see citing works

Inflammatory Bowel Disease

Ottenjann, R. (1994) · Endoscopy · doi:10.1055/s-2007-1005812 · Cited by 39 · see citing works

A novel susceptibility locus for Crohn's disease identified by whole genome association maps to a gene desert on chromosome 5p13.1 and modulates the level of expression of the prostaglandin receptor EP4

Libioulle, C., Louis, E. J., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D. P., Vermeire, S., de Wit, O., Vos, M. D., Dixon, A., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0030058.eor · Cited by 15 · see citing works

Narcissistic helpers

Palmer, M. T., & Weaver, C. T. (2007) · Nature · doi:10.1038/448416a · Cited by 9 · see citing works

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895 · see citing works

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works

Role of the gut microbiota in immunity and inflammatory disease

Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

The microbiome and cancer

Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

Glocker, E., Kotlarz, D., Boztuǧ, K., Gertz, E. M., Schäffer, A. A., Noyan, F., Perro, M., Diestelhorst, J., Saborowski, A. L., Murugan, D., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0907206 · Cited by 1,452 · see citing works

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions

Bouillon, R., Marcocci, C., Carmeliet, G., Bikle, D. D., White, J. H., Dawson-Hughes, B. F., Lips, P. T. A. M., Munns, C. F., Lazaretti‐Castro, M., Giustina, A., et al. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00126 · Cited by 1,197 · see citing works

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

Masters, S. L., Simon, A., Aksentijevich, I. A., & Kastner, D. L. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141627 · Cited by 1,063 · see citing works

Genomewide Association Study of Leprosy

Zhang, F., Huang, W., Chen, S., Sun, L., Liu, H. D., Li, Y., Cui, Y., Yan, X., Yang, H., Yang, R., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0903753 · Cited by 1,037 · see citing works

Genes and Molecules of Lactobacilli Supporting Probiotic Action

Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

Evans, D. M., Spencer, C. C. A., Pointon, J. J., Su, Z., Harvey, D., Kochan, G. T., Oppermann, U. C. T., Dilthey, A., Pirinen, M., Stone, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.873 · Cited by 891 · see citing works

The inflammasome: an integrated view

Gross, O., Thomas, C. J., Guarda, G., & Tschopp, J. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01046.x · Cited by 778 · see citing works

The Gastrointestinal Microbiome: A Review

Barko, P. C., McMichael, M. A., Swanson, K. S., & Williams, D. A. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14875 · Cited by 750 · see citing works

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 742 · see citing works

STAT3 signaling in immunity

Hillmer, E. J., Zhang, H., Li, H. S., & Watowich, S. S. (2016) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2016.05.001 · Cited by 740 · see citing works

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

Walker, A. W., Sanderson, J. D., Churcher, C. M., Parkes, G. C., Hudspith, B. N., Rayment, N. B., Brostoff, J., Parkhill, J., Dougan, G., & Petrovska, L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-7 · Cited by 727 · see citing works

Pattern recognition receptors and control of adaptive immunity

Palm, N. W., & Medzhitov, R. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00731.x · Cited by 724 · see citing works

Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700 · see citing works

Paneth Cells: Maestros of the Small Intestinal Crypts

Clevers, H. C., & Bevins, C. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183744 · Cited by 699 · see citing works

Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease

Brand, S. (2009) · Gut · doi:10.1136/gut.2008.163667 · Cited by 664 · see citing works

The CXCL8/IL-8 chemokine family and its receptors in inflammatory diseases

Russo, R. C., Garcia, C. C., Teixeira, M. M., & Amaral, F. A. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.894886 · Cited by 649 · see citing works

NF-κB in inflammation and cancer

Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 581 · see citing works

Nod2 is required for the regulation of commensal microbiota in the intestine

Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564 · see citing works

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

Ciccocioppo, R., Bernardo, M. E., Sgarella, A., Maccario, R., Avanzini, M. A., Ubezio, C., Minelli, A., Alvisi, C., Vanoli, A., Calliada, F., et al. (2011) · Gut · doi:10.1136/gut.2010.214841 · Cited by 557 · see citing works

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

Zigmond, E., Bernshtein, B., Friedlander, G., Walker, C., Yona, S., Kim, K.-W., Brenner, O. J., Krauthgamer, R., Varol, C., Müller, W., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.012 · Cited by 554 · see citing works

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551 · see citing works

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Nedjic, J., Aichinger, M., Emmerich, J., Mizushima, N., & Klein, L. (2008) · Nature · doi:10.1038/nature07208 · Cited by 533 · see citing works

Regulatory Lymphocytes and Intestinal Inflammation

Ízcue, A., Coombes, J. L., & Powrie, F. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132657 · Cited by 505 · see citing works

Common variants at five new loci associated with early-onset inflammatory bowel disease

Imielinski, M. B., Baldassano, R. N., Griffiths, A. M., Russell, R. K., Annese, V., Dubinsky, M. C., Kugathasan, S., Bradfield, J. P., Walters, T. D., Abou‐Sleiman, P. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.489 · Cited by 479 · see citing works

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy

Kotlarz, D., Beier, R., Murugan, D., Diestelhorst, J., Jensen, O., Boztuǧ, K., Pfeifer, D., Kreipe, H. H., Pfister, E., Baumann, U., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.045 · Cited by 479 · see citing works

Stevioside and related compounds: Therapeutic benefits beyond sweetness

Chatsudthipong, V., & Muanprasat, C. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.007 · Cited by 475 · see citing works

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

Utay, N. S., & Douek, D. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2848 · Cited by 473 · see citing works

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

Kleinschek, M. A., Boniface, K., Sadekova, S., Grein, J., Murphy, E. E., Turner, S. P., Raskin, L., Desai, B., Faubion, W. A., de Waal Malefyt, R., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081712 · Cited by 460 · see citing works

The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases

Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443 · see citing works

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works

Cellular Metabolism and Macrophage Functional Polarization

Zhu, L., Zhao, Q., Yang, T., Ding, W., & Zhao, Y. X. (2014) · International Reviews of Immunology · doi:10.3109/08830185.2014.969421 · Cited by 428 · see citing works

Animal Protein Intake and Risk of Inflammatory Bowel Disease: The E3N Prospective Study

Jantchou, P., Morois, S., Clavel‐Chapelon, F., Boutron‐Ruault, M., & Carbonnel, F. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.192 · Cited by 426 · see citing works

Recent Insights Into the Genetics of Inflammatory Bowel Disease

Cho, J. H., & Brant, S. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.046 · Cited by 424 · see citing works

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

Matute, J. D., Arias, A. A., Wright, N. A. M., Wrobel, I. T., Waterhouse, C. C. M., Li, X. J., Marchal, C. C., Stull, N. D., Lewis, D. B., Steele, M., et al. (2009) · Blood · doi:10.1182/blood-2009-07-231498 · Cited by 417 · see citing works

Innate immune mechanisms of colitis and colitis-associated colorectal cancer

Saleh, M., & Trinchieri, G. (2010) · Nature reviews. Immunology · doi:10.1038/nri2891 · Cited by 402 · see citing works

The impact of the microbiota on the pathogenesis of IBD: lessons from mouse infection models

Nell, S., Suerbaum, S., & Josenhans, C. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2403 · Cited by 396 · see citing works

Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease

Yates, C. M., Calder, P. C., & Rainger, G. E. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.010 · Cited by 396 · see citing works

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

Gonçalves, P., Araújo, J. R., & Santo, J. P. D. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izx029 · Cited by 396 · see citing works

Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers

Said, H. S., Suda, W., Nakagome, S., Chinen, H., Oshima, K., Kim, S., Kimura, R., Iraha, A., Ishida, H., Fujita, J., et al. (2013) · DNA Research · doi:10.1093/dnares/dst037 · Cited by 394 · see citing works

Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease

Wang, T. T., Dabbas, B., Laperrière, D., Bitton, A. J., Soualhine, H., Tavera-Mendoza, L. E., Dionne, S., Servant, M. J., Bitton, A., Seidman, E. G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.071225 · Cited by 389 · see citing works

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

Wang, C., Yosef, N., Gaublomme, J. T., Wu, C., Lee, Y., Clish, C. B., Kaminski, J., Xiao, S., zu Hörste, G. M., Pawlak, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.068 · Cited by 387 · see citing works

Butyricicoccus pullicaecorum in inflammatory bowel disease

Eeckhaut, V., Machiels, K., Perrier, C., Romero, C., Maes, S., Flahou, B., Steppe, M., Haesebrouck, F., Sas, B., Ducatelle, R., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-303611 · Cited by 368 · see citing works

Regulation of the Antimicrobial Response by NLR Proteins

Elinav, E., Strowig, T., Henao‐Mejia, J., & Flavell, R. A. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.007 · Cited by 355 · see citing works

Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s disease: results from a multicenter phase I/IIa clinical trial

de la Portilla, F., Alba, F., García‐Olmo, D., Herrerías, J. M., González-Argente, X. F., & Galindo, A. (2012) · International Journal of Colorectal Disease · doi:10.1007/s00384-012-1581-9 · Cited by 354 · see citing works

Recent Advances in the Genetics of Autoimmune Disease

Gregersen, P. K., & Olsson, L. M. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132653 · Cited by 337 · see citing works

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

van Baarlen, P., Troost, F. J., van Kraaij, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Brummer, R. J., & Kleerebezem, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000079107 · Cited by 336 · see citing works

Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice

Khan, S., Waliullah, S., Godfrey, V., Khan, M. A. W., Ramachandran, R. A., Cantarel, B. L., Behrendt, C. L., Peng, L., Hooper, L. V., & Zaki, H. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay6218 · Cited by 322 · see citing works

Autoimmune diseases: insights from genome-wide association studies

Lettre, G., & Rioux, J. D. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn246 · Cited by 317 · see citing works

Mechanisms and pathways of innate immune activation and regulation in health and cancer

Cui, J., Chen, Y., Wang, H. Y., & Wang, R. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979640 · Cited by 310 · see citing works

Intestinal microbiota in inflammatory bowel disease: Friend of foe?

Fava, F. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i5.557 · Cited by 297 · see citing works

Mitochondria: Sovereign of inflammation?

Tschopp, J. (2011) · European Journal of Immunology · doi:10.1002/eji.201141436 · Cited by 294 · see citing works

The NLRP3 inflammasome: Contributions to intestinal homeostasis

Zaki, M. H., Lamkanfi, M., & Kanneganti, T.-D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.02.002 · Cited by 290 · see citing works

Association of Psoriasis With Inflammatory Bowel Disease

Fu, Y., Lee, C., & Chi, C. (2018) · JAMA Dermatology · doi:10.1001/jamadermatol.2018.3631 · Cited by 286 · see citing works

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

Friedman, D. J., Künzli, B. M., A-Rahim, Y. I., Sevigny, J., Berberat, P. O., Enjyoji, K., Csizmadia, E., Friess, H., & Robson, S. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902869106 · Cited by 284 · see citing works

Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease

Papa, E., Docktor, M., Smillie, C. S., Weber, S., Preheim, S. P., Gevers, D., Giannoukos, G., Ciulla, D., Tabbaa, D., Ingram, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039242 · Cited by 279 · see citing works

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

Xiao, S., Yosef, N., Yang, J., Wang, Y., Zhou, L., Zhu, C. Y., Wu, C., Baloglu, E., Schmidt, D. R., Ramesh, R., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.004 · Cited by 277 · see citing works

Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H., & Liu, K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2011 · Cited by 274 · see citing works

Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

Zhao, H., Zhang, H., Wu, H., Li, H., Liu, L., Guo, J. X., Li, C., Shih, D. Q., & Zhang, X. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-57 · Cited by 272 · see citing works

IL‐10 and IL‐10 receptor defects in humans

Glocker, E., Kotlarz, D., Klein, C., Shah, N., & Grimbacher, B. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06339.x · Cited by 270 · see citing works

Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?

Smith, T. J. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002469 · Cited by 269 · see citing works

The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept

den Abbeele, P. V., de Wiele, T. V., Verstraete, W., & Possemiers, S. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00270.x · Cited by 263 · see citing works

Vitamin D metabolism and signaling in the immune system

White, J. H. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9195-z · Cited by 261 · see citing works

Development and function of TH17 cells in health and disease

Louten, J., Boniface, K., & Malefyt, R. D. W. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.04.003 · Cited by 261 · see citing works

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

Cho, J. H., & Feldman, M. A. (2015) · Nature Medicine · doi:10.1038/nm.3897 · Cited by 259 · see citing works

Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified

Bruno, G., Zaccari, P., Rocco, G., Scalese, G., Panetta, C., Porowska, B., Pontone, S., & Severi, C. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i22.2706 · Cited by 258 · see citing works

Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments

de Mattos, B. R. R., Garcia, M. P. G., Bier, J., Paiatto, L. N., Albuquerque, C. G., Souza, C. L., Fernandes, L. G. R., Tamashiro, W. M. D. S. C., & Simioni, P. U. (2015) · Mediators of Inflammation · doi:10.1155/2015/493012 · Cited by 257 · see citing works

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

Zhang, S., Langer, R., & Traverso, G. (2017) · Nano Today · doi:10.1016/j.nantod.2017.08.006 · Cited by 255 · see citing works

Scalable Variational Inference for Bayesian Variable Selection in Regression, and Its Accuracy in Genetic Association Studies

Carbonetto, P. S., & Stephens, M. (2012) · Bayesian Analysis · doi:10.1214/12-ba703 · Cited by 253 · see citing works

Changes of the cytokine profile in inflammatory bowel diseases

Műzes, G. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i41.5848 · Cited by 251 · see citing works

Dysbiotic Events in Gut Microbiota: Impact on Human Health

Schippa, S., & Conte, M. (2014) · Nutrients · doi:10.3390/nu6125786 · Cited by 247 · see citing works

Air pollution: An environmental factor contributing to intestinal disease

Beamish, L. A., Osornio-Vargas, Á. R., & Wine, E. (2011) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.02.017 · Cited by 237 · see citing works

Immunopathogenesis of inflammatory bowel disease

Matricon, J., Barnich, N., & Ardid, D. (2010) · Self/Nonself · doi:10.4161/self.1.4.13560 · Cited by 236 · see citing works

Identification of an innate T helper type 17 response to intestinal bacterial pathogens

Geddes, K., Rubino, S. J., Magalhaes, J. G., Streutker, C., Bourhis, L. L., Cho, J., Robertson, S. J., Kim, C. J., Kaul, R., Philpott, D. J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2391 · Cited by 235 · see citing works

Regulation of interleukin‐12/interleukin‐23 production and the T‐helper 17 response in humans

Lyakh, L. A., Trinchieri, G., Provezza, L., Carra, G., & Gerosa, F. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00700.x · Cited by 230 · see citing works

Inside the Mucosal Immune System

McGhee, J. R., & Fujihashi, K. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001397 · Cited by 225 · see citing works

The Microbiome and Inflammatory Bowel Disease: Is There a Therapeutic Role for Fecal Microbiota Transplantation?

Damman, C. J., Miller, S. I., Surawicz, C. M., & Zisman, T. L. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.93 · Cited by 224 · see citing works

Revisiting Mendelian disorders through exome sequencing

Ku, C., Naidoo, N., & Yudi Pawitan, Y. (2011) · Human Genetics · doi:10.1007/s00439-011-0964-2 · Cited by 219 · see citing works

NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease

Strober, W., & Watanabe, T. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.29 · Cited by 218 · see citing works

STAT3 in CD4+ T helper cell differentiation and inflammatory diseases

Egwuagu, C. E. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.003 · Cited by 218 · see citing works

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria

Varol, C., Zigmond, E., & Jung, S. (2010) · Nature reviews. Immunology · doi:10.1038/nri2778 · Cited by 208 · see citing works

Intestinal Effector T Cells in Health and Disease

Maynard, C. L., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.012 · Cited by 207 · see citing works

Review: Mammalian peptidoglycan recognition proteins (PGRPs) in innate immunity

Dziarski, R., & Gupta, D. (2010) · Innate Immunity · doi:10.1177/1753425910366059 · Cited by 203 · see citing works

NOD-like receptors and the innate immune system: Coping with danger, damage and death

Kersse, K., Bertrand, M. J. M., Lamkanfi, M., & Vandenabeele, P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.003 · Cited by 202 · see citing works

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

Feng, T., Qin, H., Wang, L., Benveniste, E. N., Elson, C. O., & Cong, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001454 · Cited by 200 · see citing works

Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women

Li, W., Han, J., Chan, A. T., & Qureshi, A. A. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202143 · Cited by 195 · see citing works

Psoriasis associated with ulcerative colitis and Crohn's disease

Cohen, A., Dreiher, J., & Birkenfeld, S. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2008.03031.x · Cited by 194 · see citing works

Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

Wang, H., Chao, K., Ng, S. C., Bai, A. H. C., Yu, Q., Yu, J. Q., Li, M., Cui, Y., Chen, M., Hu, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-0901-8 · Cited by 186 · see citing works

Rapidly expanding knowledge on the role of the gut microbiome in health and disease

Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 185 · see citing works

IL-21 and T follicular helper cells

Spolski, R. J., & Leonard, W. J. (2009) · International Immunology · doi:10.1093/intimm/dxp112 · Cited by 182 · see citing works

The pursuit of genome-wide association studies: where are we now?

Ku, C., Loy, E. Y., Yudi Pawitan, Y., & Chia, K. S. (2010) · Journal of Human Genetics · doi:10.1038/jhg.2010.19 · Cited by 181 · see citing works

The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy

Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 180 · see citing works

Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action

Yousef, M., Pichyangkura, R., Soodvilai, S., Chatsudthipong, V., & Muanprasat, C. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.013 · Cited by 180 · see citing works

Genetics of inflammatory bowel disease in Asia: Systematic review and meta-analysis

Ng, S. C., Tsoi, K. K. F., Kamm, M. A., Xia, B., Wu, J. C., Chan, F. K. L., & Sung, J. J. �. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21845 · Cited by 179 · see citing works

The Immunological Basis of Inflammatory Bowel Disease

Silva, F. A. R., Rodrigues, B. L., Ayrizono, M. D. L. S., & Leal, R. F. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2097274 · Cited by 178 · see citing works

The Genetics of Inflammatory Bowel Disease

Gathungu, G. N., & Cho, J. H. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0998-4_1 · Cited by 1 · see citing works

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

Lees, C. W., & Satsangi, J. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.45 · Cited by 94 · see citing works

The immunological and genetic basis of inflammatory bowel disease

Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,882 · see citing works

The expanding universe of inflammatory bowel disease genetics

Achkar, J., & Duerr, R. H. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283009c92 · Cited by 26 · see citing works

Update on genetics in inflammatory disease

Noomen, C. G., Hommes, D. W., & Fidder, H. H. (2009) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2009.02.005 · Cited by 28 · see citing works