Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico
Open accessAbstract
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We evaluated genetic diversity, linkage disequilibrium patterns, and extent of haplotype sharing using genomewide data from Mexican Mestizos from regions with different histories of admixture and particular population dynamics. Ancestry was evaluated by including 1 Mexican Amerindian group and data from the HapMap. Our results provide evidence of genetic differences between Mexican subpopulations that should be considered in the design and analysis of association studies of complex diseases. In addition, these results support the notion that a haplotype map of the Mexican Mestizo population can reduce the number of tag SNPs required to characterize common genetic variation in this population. This is one of the first genomewide genotyping efforts of a recently admixed population in Latin America.
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Individuals from countries across South America, the Caribbean, and Mexico have different profiles of genetic ancestry molded by each population's unique history and interactions with local Native American populations.
“Individuals from countries across South America, the Caribbean, and Mexico have different profiles of genetic ancestry molded by each population’s unique history and interactions with local Native American populations.1,19–25”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [22]
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- Authors
- Silva-Zolezzi, I., Hidalgo-Miranda, A., Estrada-Gil, J., Fernandez-Lopez, J. C., Uribe-Figueroa, L., Contreras, A., Balam-Ortiz, E., del Bosque-Plata, L., Velazquez-Fernandez, D., Lara, C., Goya, R., Hernandez-Lemus, E., Davila, C., Barrientos, E., March, S., & Jimenez-Sanchez, G.
- Affiliations
- National Institute of Genomic Medicine (INMEGEN), Periferico Sur No. 4124, Torre Zafiro II, 6to. Piso, Col. Jardines del Pedregal, Mexico D.F. 01900, Mexico
- National Institute of Genomic Medicine (MX)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-05-26
- Volume
- 106
- Issue
- 21
- Pages
- 8611-8616
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2680428
- OpenAlex
- W2159379246
- Cited by
- 417
- References
- 2
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 12 · 2023: 16 · 2022: 19 · 2021: 19 · 2020: 27 · 2019: 29 · 2018: 34 · 2017: 35 · 2016: 25 · 2015: 48 · 2014: 37 · 2013: 25 · 2012: 24
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundación Mexicana para la Salud
- Australian Government
- Instituto Nacional de Medicina Genómica
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- Mexican mestizo population, genomic diversity, linkage disequilibrium, HapMap, tag SNPs, genotype imputation, admixture, population substructure, common genetic variants, genomic medicine
- MeSH terms
- Alleles, Haplotypes, Humans, Indians, North American, Medicine, Mexico, Genetic Variation, Genome, Human, Genomics
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