Targeting atherosclerosis by using modular, multifunctional micelles
Open accessAbstract
Subtle clotting that occurs on the luminal surface of atherosclerotic plaques presents a novel target for nanoparticle-based diagnostics and therapeutics. We have developed modular multifunctional micelles that contain a targeting element, a fluorophore, and, when desired, a drug component in the same particle. Targeting atherosclerotic plaques in ApoE-null mice fed a high-fat diet was accomplished with the pentapeptide cysteine-arginine-glutamic acid-lysine-alanine, which binds to clotted plasma proteins. The fluorescent micelles bind to the entire surface of the plaque, and notably, concentrate at the shoulders of the plaque, a location that is prone to rupture. We also show that the targeted micelles deliver an increased concentration of the anticoagulant drug hirulog to the plaque compared with untargeted micelles.
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Peters et al. used micelles to target fibrin on the luminal surface of atherosclerotic plaques and deliver bivalirudin.
“Peters et al.113 used micelles to target fibrin deposited on the luminal surface of atherosclerotic plaques and deliver the anticoagulant drug bivalirudin (Hirulog; Biogen Idec).”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [113]
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Cites
Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.179918 · Cited by 3,277 · see citing works
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · see citing works
Richardson, P. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90953-7 · Cited by 1,260 · see citing works
Thrombosis as a factor in the pathogenesis of coronary atherosclerosis
Duguid, J. B. (1946) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700580207 · Cited by 798 · see citing works
Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression
Reddick, R. L., Zhang, S. H., & Maeda, N. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.141 · Cited by 633 · see citing works
Biomimetic amplification of nanoparticle homing to tumors
Simberg, D., Duza, T., Park, J. H., Essler, M., Pilch, J., Zhang, L., Derfus, A. M., Yang, M., Hoffman, R. M., Bhatia, S. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610298104 · Cited by 473 · see citing works
Self-citationDesign and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin
Maraganore, J. M., Bourdon, P. R., Jablonski, J.-A., et al. (1990) · Biochemistry · doi:10.1021/bi00482a021 · Cited by 470 · see citing works
Thrombosis as a factor in the pathogenesis of aortic atherosclerosis
Duguid, J. B. (1948) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700600107 · Cited by 272 · see citing works
Anatomic features in victims of sudden coronary death. Coronary artery pathology.
Davies, M. J. (1992) · PubMed · Cited by 260 · see citing works
Targeting of albumin-embedded paclitaxel nanoparticles to tumors
Karmali, P. P., Kotamraju, V. R., Kastantin, M. J., Black, M., Missirlis, D., Tirrell, M., & Ruoslahti, E. I. (2008) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2008.07.007 · Cited by 235 · see citing works
Self-citationBriley-Saebo, K. C., Shaw, P. X., Mulder, W. J. M., Choi, S., Vucic, E., Aguinaldo, J. G. S., Witztum, J. L., Fuster, V., Tsimikas, S., & Fayad, Z. A. (2008) · Circulation · doi:10.1161/circulationaha.107.757120 · Cited by 184 · see citing works
Eitzman, D. T., Westrick, R. J., Xu, Z., Tyson, J. A., & Ginsburg, D. (2000) · Blood · doi:10.1182/blood.v96.13.4212 · Cited by 182 · see citing works
In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging
Kelly, K. A., Nahrendorf, M., Yu, A. M., Reynolds, F., & Weissleder, R. (2006) · Molecular Imaging and Biology · doi:10.1007/s11307-006-0043-6 · Cited by 136 · see citing works
A practical approach to using mice in atherosclerosis research.
Whitman, S. C. (2004) · PubMed · Cited by 128 · see citing works
Molecular Imaging of Human Thrombus With Novel Abciximab Immunobubbles and Ultrasound
Alonso, A., Martina, A. D., Stroick, M., Fatar, M., Griebe, M., Pochon, S., Schneider, M., Hennerici, M. G., Allémann, É., & Meairs, S. P. (2007) · Stroke · doi:10.1161/strokeaha.106.471391 · Cited by 121 · see citing works
Stoll, P., Bassler, N., Hagemeyer, C. E., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.138875 · Cited by 85 · see citing works
van der Wal, A. C. (2007) · Heart · doi:10.1136/hrt.2004.038364 · Cited by 73 · see citing works
Maeda, N., Johnson, L. A., Kim, S., Hagaman, J. R., Friedman, M. H., & Reddick, R. L. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.12.006 · Cited by 72 · see citing works
In Vivo Interrogation of the Molecular Display of Atherosclerotic Lesion Surfaces
Liu, C., Bhattacharjee, G., Boisvert, W. A., Dilley, R. B., & Edgington, T. S. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63545-6 · Cited by 69 · see citing works
Ivey, M. E., & Little, P. J. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.04.019 · Cited by 54 · see citing works
Houston, P., Goodman, J., Lewis, A., Campbell, C. J., & Braddock, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02191-3 · Cited by 45 · see citing works
Bode, C., Hudelmayer, M., Mehwald, P., et al. (1994) · Circulation · doi:10.1161/01.cir.90.4.1956 · Cited by 44 · see citing works
Putative Murine Models of Plaque Rupture
Falk, E., Schwartz, S. M., Galis, Z. S., & Rosenfeld, M. E. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000261572.33474.e0 · Cited by 43 · see citing works
Prolonged Activation of Prothrombin on the Vascular Wall After Arterial Injury
Ghigliotti, G., Waissbluth, A. D., Speidel, C. M., et al. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.2.250 · Cited by 30 · see citing works
Eitzman, D. T., Westrick, R. J., Xu, Z., et al. (2000) · Blood · doi:10.1182/blood.v96.13.4212.h8004212_4212_4215 · Cited by 14 · see citing works
Fibrinogen and atherosclerosis.
Smith, E. B. (1993) · PubMed · Cited by 12 · see citing works
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Application of Light Scattering Techniques to Nanoparticle Characterization and Development
Carvalho, P. M., Felício, M. R., Santos, N. C., Gonçalves, S., & Domingues, M. M. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00237 · Cited by 402 · see citing works
Ligand-installed nanocarriers toward precision therapy
Mi, P., Cabral, H., & Kataoka, K. (2020) · Advanced Materials · doi:10.1002/adma.201902604 · Cited by 350 · see citing works
Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo
Lewis, D. R., Petersen, L. K., York, A. W., Zablocki, K. R., Joseph, L. B., Kholodovych, V., Prud’homme, R. K., Uhrich, K. E., & Moghe, P. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424594112 · Cited by 111 · see citing works
MYERSON, J., HE, L., LANZA, G., TOLLEFSEN, D., & WICKLINE, S. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04339.x · Cited by 96 · see citing works
Jeon, J., & Shell, M. S. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.03.019 · Cited by 16 · see citing works
- Authors
- Peters, D., Kastantin, M., Kotamraju, V. R., Karmali, P. P., Gujraty, K., Tirrell, M., & Ruoslahti, E.
- Affiliations
- University of California, Santa Barbara (US)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-06-16
- Volume
- 106
- Issue
- 24
- Pages
- 9815-9819
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2689312
- OpenAlex
- W2130512481
- Cited by
- 271
- References
- 26
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 10 · 2022: 14 · 2021: 20 · 2020: 17 · 2019: 15 · 2018: 19 · 2017: 16 · 2016: 21 · 2015: 21 · 2014: 27 · 2013: 20 · 2012: 18
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1s10rr017753-01)
- National Heart, Lung, and Blood Institute (HL070818)
- National Center for Research Resources (1S10RR017753)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- atherosclerosis, atherosclerotic plaque targeting, nanoparticle drug delivery, ApoE-null mice, high-fat diet, plaque rupture, hirudin, fluorescence imaging
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Fluorescent Antibody Technique, Micelles, Mice, Knockout, Atherosclerosis, Mice
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