Ligand-installed nanocarriers toward precision therapy

Nanocarriers as an emerging platform for cancer therapy

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Principles of nanoparticle design for overcoming biological barriers to drug delivery

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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

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Stimuli-responsive nanocarriers for drug delivery

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Recent advances with liposomes as pharmaceutical carriers

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Nanoparticle therapeutics: an emerging treatment modality for cancer

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Block copolymer micelles for drug delivery: design, characterization and biological significance

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The dawning era of polymer therapeutics

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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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Development, maintenance and disruption of the blood-brain barrier

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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

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Polymer Vesicles

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Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

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The Path to Personalized Medicine

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Polymer conjugates as anticancer nanomedicines

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Transport properties of two finite armchair graphene nanoribbons

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Structure and function of immunoglobulins

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Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

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Design of polymeric nanoparticles for biomedical delivery applications

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Ligand-targeted therapeutics in anticancer therapy

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Pharmacokinetics of Pegylated Liposomal Doxorubicin

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Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

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A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

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Nanocrystal targeting in vivo

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Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

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Block copolymer micelles in nanomedicine applications

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

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Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

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Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

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Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence

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Disrupting tumour blood vessels

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Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

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Nanoparticle-Aptamer Bioconjugates

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Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Yu, M. K., Park, J., & Jon, S. (2012) · Theranostics · doi:10.7150/thno.3463 · Cited by 884 · see citing works

Targeting of drugs and nanoparticles to tumors

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Strategies for advancing cancer nanomedicine

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The transferrin receptor and the targeted delivery of therapeutic agents against cancer

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Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.

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Magnetoferritin nanoparticles for targeting and visualizing tumour tissues

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A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics

Steichen, S. D., Caldorera-Moore, M., & Peppas, N. A. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.12.006 · Cited by 751 · see citing works

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

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Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

van Zandwijk, N., Pavlakis, N., Kao, S. C.-H., Linton, A., Boyer, M. J., Clarke, S. J., Huynh, Y., Chrzanowska, A., FULHAM, M. J., Bailey, D. L., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(17)30621-6 · Cited by 714 · see citing works

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

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ATP-triggered anticancer drug delivery

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Ligand binding assays at equilibrium: validation and interpretation

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Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.

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Super pH-Sensitive Multifunctional Polymeric Micelle

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The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform

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Advances in targeting the folate receptor in the treatment/imaging of cancers

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Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

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Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases

Tapeinos, C., Battaglini, M., & Ciofani, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.033 · Cited by 541 · see citing works

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

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A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

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H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection

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Nanoparticles that communicate in vivo to amplify tumour targeting

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Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics

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Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting

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Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

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Vascular Targeted Nanoparticles for Imaging and Treatment of Brain Tumors

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Sialic acids in cancer biology and immunity

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Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

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Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

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Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug

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Clinical experiences with systemically administered siRNA-based therapeutics in cancer

Zuckerman, J. E., & Davis, M. E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4685 · Cited by 424 · see citing works

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

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Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin

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Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates

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Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier.

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Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance

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Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma

Fan, K., Jia, X., Zhou, M., Wang, K., Conde, J., He, J., Tian, J., & Yan, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b06969 · Cited by 398 · see citing works

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

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Targeting to cells of fluorescent liposomes covalently coupled with monoclonal antibody or protein A

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Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization

Wang, S., Huang, P., & Chen, X. S. (2016) · Advanced Materials · doi:10.1002/adma.201601498 · Cited by 384 · see citing works

Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer DrugsIn vivo

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Endothelial α _ν β ₃ Integrin–Targeted Fumagillin Nanoparticles Inhibit Angiogenesis in Atherosclerosis

Winter, P. M., Neubauer, A. M., Caruthers, S. D., Harris, T. D., Robertson, J. D., Williams, T. A., Schmieder, A. H., Hu, G., Allen, J. S., Lacy, E. K., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000235724.11299.76 · Cited by 379 · see citing works

Specific Targeting of Brain Tumors with an Optical/Magnetic Resonance Imaging Nanoprobe across the Blood-Brain Barrier

Omid Veiseh, A., Sun, C., Fang, C., Bhattarai, N., Gunn, J., Kievit, F. M., Du, K. N., Pullar, B. J., Lee, D., Ellenbogen, R. G., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1157 · Cited by 378 · see citing works

Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment

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Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

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Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles

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Multifunctional nanoparticles for brain tumor imaging and therapy

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Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors

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Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

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Polymer–drug conjugates: Origins, progress to date and future directions

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In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles

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